STRINGSTRING
CACNA1S CACNA1S PIK3R3 PIK3R3 MAP2K1 MAP2K1 PIK3CD PIK3CD HRAS HRAS BCAR1 BCAR1 GRB2 GRB2 PLCB4 PLCB4 ADCY6 ADCY6 CREB5 CREB5 STAT3 STAT3 ADCY8 ADCY8 MAPK10 MAPK10 PTK2 PTK2 ADCY2 ADCY2 IGFBP3 IGFBP3 MAPK1 MAPK1 ATF2 ATF2 MAPK11 MAPK11 GSK3B GSK3B PIK3CB PIK3CB SOS2 SOS2 ATF6B ATF6B GNAI1 GNAI1 ENSMFAP00000009633 ENSMFAP00000009633 SOCS1 SOCS1 SOCS3 SOCS3 PRKACA PRKACA JUNB JUNB SSTR1 SSTR1 GHV GHV MAP3K1 MAP3K1 FOS FOS STAT5A STAT5A SSTR3 SSTR3 PRKCA PRKCA SSTR2 SSTR2 PRKACG PRKACG IGF1 IGF1 PRKCB PRKCB CREB3L1 CREB3L1 POU1F1 POU1F1 SOCS2 SOCS2 SOS1 SOS1 AKT1 AKT1 ADCY10 ADCY10 GNAI2 GNAI2 AKT3 AKT3 ITPR2 ITPR2 CREB3L2 CREB3L2 PLCB1 PLCB1 GNAS GNAS GHRL GHRL SST SST PRKACB PRKACB GHRH GHRH CREB3 CREB3 PLCB3 PLCB3 SHC1 SHC1 PIK3CA PIK3CA PIK3R1 PIK3R1 IGFALS IGFALS MAPK3 MAPK3 SSTR5 SSTR5 IRS2 IRS2 PLCG2 PLCG2 MAPK9 MAPK9 PRKCG PRKCG ITPR1 ITPR1 CACNA1F CACNA1F NRAS NRAS PLCB2 PLCB2 STAT1 STAT1 ADCY5 ADCY5 AKT2 AKT2 CRKL CRKL JAK2 JAK2 KRAS KRAS GNAQ GNAQ IRS4 IRS4 CREBBP CREBBP PIK3R2 PIK3R2 GHR GHR GNAI3 GNAI3 ADCY7 ADCY7 MAP2K3 MAP2K3 MAPK14 MAPK14 ADCY1 ADCY1 RAF1 RAF1 MAPK8 MAPK8 ADCY3 ADCY3 SHC4 SHC4 GHSR GHSR SHC2 SHC2 MAP2K4 MAP2K4 GNA11 GNA11 SHC3 SHC3 ITPR3 ITPR3 MTOR MTOR IRS1 IRS1 CREB3L3 CREB3L3 MAP2K6 MAP2K6 MAP2K2 MAP2K2 CACNA1D CACNA1D CREB1 CREB1 ADCY4 ADCY4 EP300 EP300 ATF4 ATF4 CRK CRK PLCG1 PLCG1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
GRB2Growth factor receptor-binding protein 2. (217 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
GNAI1G protein subunit alpha i1. (422 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
GHVUncharacterized protein. (217 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1683 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (418 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
IGF1Insulin like growth factor 1. (159 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
POU1F1POU domain protein. (291 aa)
SOCS2Suppressor of cytokine signaling 2. (212 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ADCY10Adenylate cyclase 10. (1562 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNASGNAS complex locus. (1023 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
SSTSomatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. (116 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
SHC1SHC adaptor protein 1. (584 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (605 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (223 aa)
IRS2Insulin receptor substrate 2. (1279 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
PRKCGProtein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
NRASUncharacterized protein. (189 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GNAQG protein subunit alpha q. (359 aa)
IRS4Insulin receptor substrate 4. (1222 aa)
CREBBPCREB binding protein. (2442 aa)
PIK3R2Uncharacterized protein. (694 aa)
GHRGrowth hormone receptor. (645 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
SHC4SHC adaptor protein 4. (630 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SHC2Uncharacterized protein. (516 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
GNA11G protein subunit alpha 11. (359 aa)
SHC3SHC adaptor protein 3. (598 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (301 aa)
MAP2K6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (334 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
EP300E1A binding protein p300. (2414 aa)
ATF4Activating transcription factor 4. (351 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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