43 items (Macaca fascicularis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	MOGAT3	Monoacylglycerol O-acyltransferase 3. (341 aa)
	APOB	Apolipoprotein B. (4555 aa)
	PLA2G12A	Phospholipase A2 group XIIA. (189 aa)
	PLA2G2E	Phospholipase A(2). (142 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2268 aa)
	PNLIP	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (465 aa)
	GOT2	Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (430 aa)
	PLPP3	acidPPc domain-containing protein. (353 aa)
	PLPP1	Phospholipid phosphatase 1. (285 aa)
	PLA2G3	Phospholipase A2 group III. (509 aa)
	MOGAT2	Monoacylglycerol O-acyltransferase 2. (334 aa)
	FABP1	Fatty acid binding protein 1. (127 aa)
	SLC27A4	Long-chain fatty acid transport protein 4; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity); [...] (649 aa)
	PLA2G5	Phospholipase A(2). (138 aa)
	ACAT2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	PLA2G12B	Phospholipase A2 group XIIB. (195 aa)
	LIPF	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (408 aa)
	DGAT2	Diacylglycerol O-acyltransferase 2. (388 aa)
	NPC1L1	NPC1 like intracellular cholesterol transporter 1. (1355 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	PLPP2	Phospholipid phosphatase 2. (302 aa)
	ACAT1	Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] (459 aa)
	PLA2G2C	Phospholipase A(2). (151 aa)
	PLA2G1B	Phospholipase A(2). (148 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (673 aa)
	APOA4	Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons; Belongs to the apolipoprotein A1/A4/E family. (441 aa)
	CEL	Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family. (734 aa)
	CLPS	Colipase. (112 aa)
	AGPAT1	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (283 aa)
	PLA2G10	Phospholipase A(2). (165 aa)
	PLA2G2D	Phospholipase A(2). (161 aa)
	MTTP	Microsomal triglyceride transfer protein. (909 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (651 aa)
	DGAT1	O-acyltransferase. (491 aa)
	AGPAT2	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa)
	SLC27A1	Solute carrier family 27 member 1. (646 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. (267 aa)
	FABP2	Fatty acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	PLA2G2A	Phospholipase A(2). (144 aa)
	PLA2G2F	Phospholipase A(2). (199 aa)
	CLPSL1	Colipase like 1. (119 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	PNLIPRP2	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (469 aa)

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	AGPAT1	ENSMFAP00000005316	ENSMFAP00000030508	ATP binding cassette subfamily A member 1.	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.616
ABCA1	APOA1	ENSMFAP00000005316	ENSMFAP00000037249	ATP binding cassette subfamily A member 1.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.	0.934
ABCA1	APOB	ENSMFAP00000005316	ENSMFAP00000001511	ATP binding cassette subfamily A member 1.	Apolipoprotein B.	0.867
ABCA1	CD36	ENSMFAP00000005316	ENSMFAP00000025488	ATP binding cassette subfamily A member 1.	CD36 molecule; Belongs to the CD36 family.	0.602
ABCA1	MTTP	ENSMFAP00000005316	ENSMFAP00000033199	ATP binding cassette subfamily A member 1.	Microsomal triglyceride transfer protein.	0.526
ABCA1	NPC1L1	ENSMFAP00000005316	ENSMFAP00000022837	ATP binding cassette subfamily A member 1.	NPC1 like intracellular cholesterol transporter 1.	0.727
ABCA1	SCARB1	ENSMFAP00000005316	ENSMFAP00000045188	ATP binding cassette subfamily A member 1.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.616
ABCG5	ABCG8	ENSMFAP00000033887	ENSMFAP00000028146	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 8.	0.999
ABCG5	APOB	ENSMFAP00000033887	ENSMFAP00000001511	ATP binding cassette subfamily G member 5.	Apolipoprotein B.	0.573
ABCG5	MTTP	ENSMFAP00000033887	ENSMFAP00000033199	ATP binding cassette subfamily G member 5.	Microsomal triglyceride transfer protein.	0.552
ABCG5	NPC1L1	ENSMFAP00000033887	ENSMFAP00000022837	ATP binding cassette subfamily G member 5.	NPC1 like intracellular cholesterol transporter 1.	0.857
ABCG5	SCARB1	ENSMFAP00000033887	ENSMFAP00000045188	ATP binding cassette subfamily G member 5.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.407
ABCG8	ABCG5	ENSMFAP00000028146	ENSMFAP00000033887	ATP binding cassette subfamily G member 8.	ATP binding cassette subfamily G member 5.	0.999
ABCG8	APOB	ENSMFAP00000028146	ENSMFAP00000001511	ATP binding cassette subfamily G member 8.	Apolipoprotein B.	0.514
ABCG8	NPC1L1	ENSMFAP00000028146	ENSMFAP00000022837	ATP binding cassette subfamily G member 8.	NPC1 like intracellular cholesterol transporter 1.	0.845
ABCG8	SCARB1	ENSMFAP00000028146	ENSMFAP00000045188	ATP binding cassette subfamily G member 8.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.407
ACAT1	ACAT2	ENSMFAP00000027085	ENSMFAP00000021500	Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...]	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.912
ACAT2	ACAT1	ENSMFAP00000021500	ENSMFAP00000027085	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...]	0.912
AGPAT1	ABCA1	ENSMFAP00000030508	ENSMFAP00000005316	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	ATP binding cassette subfamily A member 1.	0.616
AGPAT1	AGPAT2	ENSMFAP00000030508	ENSMFAP00000035644	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.907

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