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HDAC2 HDAC2 GRIA2 GRIA2 MAOB MAOB CREB5 CREB5 PPP1CA PPP1CA GRIA4 GRIA4 ARC ARC ATF2 ATF2 CALM3 CALM3 CALML4 CALML4 GRIN3B GRIN3B STX1A STX1A ATF6B ATF6B CAMK2D CAMK2D HDAC1 HDAC1 ENSMFAP00000009633 ENSMFAP00000009633 PRKACA PRKACA GRIN2B GRIN2B PPP3CC PPP3CC CALML3 CALML3 GRIA3 GRIA3 FOS FOS DRD1 DRD1 PRKCA PRKCA DDC DDC SLC18A1 SLC18A1 PRKACG PRKACG GRIN1 GRIN1 PRKCB PRKCB CREB3L1 CREB3L1 SLC18A2 SLC18A2 PPP3R1 PPP3R1 GRIN2D GRIN2D PPP3CB PPP3CB CREB3L2 CREB3L2 CAMK2A CAMK2A PPP1CB PPP1CB GRIA1 GRIA1 GNAS GNAS PDYN PDYN PRKACB PRKACB ENSMFAP00000025317 ENSMFAP00000025317 GRIN3A GRIN3A CREB3 CREB3 GRIN2C GRIN2C MAOA MAOA PPP1R1B PPP1R1B TH TH PRKCG PRKCG CAMK4 CAMK4 GRIN2A GRIN2A ADCY5 ADCY5 PPP3CA PPP3CA SLC6A3 SLC6A3 FOSB FOSB PPP1CC PPP1CC SIRT1 SIRT1 CALML6 CALML6 CREB3L3 CREB3L3 CACNA1D CACNA1D CREB1 CREB1 ATF4 ATF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
GRIA2Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] (883 aa)
MAOBAmine oxidase. (520 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
GRIA4Glutamate receptor 4; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] (902 aa)
ARCActivity regulated cytoskeleton associated protein. (471 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CALML4Calmodulin like 4. (193 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (753 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GRIA3Glutamate receptor 3; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] (894 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
DDCUncharacterized protein. (480 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
SLC18A2Solute carrier family 18 member A2. (485 aa)
PPP3R1Uncharacterized protein. (189 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1062 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
GRIA1Glutamate receptor 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulati [...] (916 aa)
GNASGNAS complex locus. (1023 aa)
PDYNProdynorphin. (253 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1242 aa)
MAOAAmine oxidase. (359 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
THTyrosine hydroxylase. (529 aa)
PRKCGProtein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
SLC6A3Sodium-dependent dopamine transporter; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity); Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. (620 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
SIRT1Sirtuin 1. (743 aa)
CALML6Calmodulin like 6. (181 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (301 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ATF4Activating transcription factor 4. (351 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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