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HDAC2 HDAC2 MAP2K1 MAP2K1 HRAS HRAS GRB2 GRB2 LOC102121517 LOC102121517 CRH CRH MAOB MAOB H2AZ2 H2AZ2 CREB5 CREB5 H2BC13 H2BC13 HDAC10 HDAC10 GNGT1 GNGT1 HDAC11 HDAC11 LOC102137233 LOC102137233 PPP1CA PPP1CA MAPK1 MAPK1 ATF2 ATF2 H2AZ1 H2AZ1 HDAC3 HDAC3 ENSMFAP00000006047 ENSMFAP00000006047 GNG4 GNG4 CALM3 CALM3 CALML4 CALML4 GRIN3B GRIN3B SOS2 SOS2 ATF6B ATF6B BRAF BRAF HDAC1 HDAC1 GNAI1 GNAI1 GNGT2 GNGT2 ENSMFAP00000009633 ENSMFAP00000009633 HIST1H3B HIST1H3B LOC102147067 LOC102147067 HIST1H2BO HIST1H2BO PRKACA PRKACA H2BC14 H2BC14 H2AC21 H2AC21 ENSMFAP00000010040 ENSMFAP00000010040 H2BC1 H2BC1 H2AC1 H2AC1 H2AC20 H2AC20 ENSMFAP00000010221 ENSMFAP00000010221 GRIN2B GRIN2B ADORA2B ADORA2B CALML3 CALML3 LOC102136612 LOC102136612 ENSMFAP00000010627 ENSMFAP00000010627 H2BC11 H2BC11 H2AX H2AX H2AC6 H2AC6 H2AC12 H2AC12 G8F3V0_MACFA G8F3V0_MACFA G7P2P1_MACFA G7P2P1_MACFA H2AC7 H2AC7 DRD1 DRD1 HDAC9 HDAC9 H2AJ H2AJ LOC102130997 LOC102130997 ENSMFAP00000012034 ENSMFAP00000012034 H3-4 H3-4 ENSMFAP00000012162 ENSMFAP00000012162 H2AW H2AW H2BU1 H2BU1 H2AC14 H2AC14 H2BC5 H2BC5 DDC DDC G8F2Z2_MACFA G8F2Z2_MACFA LOC102146894 LOC102146894 SLC18A1 SLC18A1 GNB3 GNB3 H2BC3 H2BC3 HIST2H2BE HIST2H2BE GNG5 GNG5 G8F5U3_MACFA G8F5U3_MACFA PRKACG PRKACG ENSMFAP00000014622 ENSMFAP00000014622 GRIN1 GRIN1 CREB3L1 CREB3L1 ARAF ARAF SLC18A2 SLC18A2 GRIN2D GRIN2D ADORA2A ADORA2A SOS1 SOS1 GNAI2 GNAI2 HDAC4 HDAC4 GNG11 GNG11 CREB3L2 CREB3L2 MACROH2A2 MACROH2A2 H3F3B H3F3B ENSMFAP00000022290 ENSMFAP00000022290 PPP1CB PPP1CB GNG12 GNG12 DRD2 DRD2 HDAC5 HDAC5 GNAS GNAS NPY NPY PDYN PDYN HDAC6 HDAC6 PRKACB PRKACB ENSMFAP00000025317 ENSMFAP00000025317 HDAC7 HDAC7 HAT1 HAT1 GRIN3A GRIN3A CREB3 CREB3 SHC1 SHC1 NTRK2 NTRK2 GRIN2C GRIN2C MAOA MAOA PPP1R1B PPP1R1B MAPK3 MAPK3 TH TH LOC102133669 LOC102133669 NRAS NRAS CAMK4 CAMK4 GRIN2A GRIN2A HDAC8 HDAC8 ADCY5 ADCY5 H2BC18 H2BC18 ENSMFAP00000034298 ENSMFAP00000034298 GNB5 GNB5 KRAS KRAS BDNF BDNF SLC6A3 SLC6A3 GNG2 GNG2 GNAI3 GNAI3 FOSB FOSB PPP1CC PPP1CC RAF1 RAF1 SLC29A1 SLC29A1 SHC4 SHC4 SHC2 SHC2 SHC3 SHC3 H2BW2 H2BW2 GNB4 GNB4 GNG10 GNG10 CALML6 CALML6 CREB3L3 CREB3L3 H2BC15 H2BC15 GNB1 GNB1 GNG3 GNG3 SLC29A2 SLC29A2 CREB1 CREB1 SLC29A3 SLC29A3 ATF4 ATF4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor-binding protein 2. (217 aa)
LOC102121517Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (103 aa)
CRHCorticotropin releasing hormone. (196 aa)
MAOBAmine oxidase. (520 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (136 aa)
HDAC10Histone deacetylase 10. (672 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
HDAC11Histone deacetylase 11; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (319 aa)
LOC102137233Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
ENSMFAP00000006047Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CALML4Calmodulin like 4. (193 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (753 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
GNAI1G protein subunit alpha i1. (422 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
HIST1H3BHistone H3; Belongs to the histone H3 family. (136 aa)
LOC102147067Histone H3; Belongs to the histone H3 family. (136 aa)
HIST1H2BOHistone H2B; Belongs to the histone H2B family. (126 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC21Histone H2A; Belongs to the histone H2A family. (130 aa)
ENSMFAP00000010040Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
H2AC1Histone H2A; Belongs to the histone H2A family. (131 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
ENSMFAP00000010221Histone H2A; Belongs to the histone H2A family. (130 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (394 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
LOC102136612Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
ENSMFAP00000010627Histone H3; Belongs to the histone H3 family. (136 aa)
H2BC11Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AC12Histone H2A; Belongs to the histone H2A family. (128 aa)
G8F3V0_MACFAHistone H2A; Belongs to the histone H2A family. (130 aa)
G7P2P1_MACFAHistone H2B; Belongs to the histone H2B family. (126 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
H2AJHistone H2A.J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (129 aa)
LOC102130997Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000012034Histone H3; Belongs to the histone H3 family. (136 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000012162Histone H3; Belongs to the histone H3 family. (136 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC14Histone H2A; Belongs to the histone H2A family. (128 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
DDCUncharacterized protein. (480 aa)
G8F2Z2_MACFAHistone H2B; Belongs to the histone H2B family. (126 aa)
LOC102146894Histone domain-containing protein. (136 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
GNB3G protein subunit beta 3. (340 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
G8F5U3_MACFAHistone H3; Belongs to the histone H3 family. (136 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
ENSMFAP00000014622Histone H2B; Belongs to the histone H2B family. (126 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
SLC18A2Solute carrier family 18 member A2. (485 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1062 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000022290Histone domain-containing protein. (113 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1122 aa)
GNASGNAS complex locus. (1023 aa)
NPYNeuropeptide Y. (97 aa)
PDYNProdynorphin. (253 aa)
HDAC6Histone deacetylase 6. (1215 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1008 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
SHC1SHC adaptor protein 1. (584 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1242 aa)
MAOAAmine oxidase. (359 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
THTyrosine hydroxylase. (529 aa)
LOC102133669Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
NRASUncharacterized protein. (189 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (134 aa)
ENSMFAP00000034298Histone H3; Belongs to the histone H3 family. (141 aa)
GNB5G protein subunit beta 5. (409 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
SLC6A3Sodium-dependent dopamine transporter; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity); Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. (620 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
GNAI3G protein subunit alpha i3. (354 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (456 aa)
SHC4SHC adaptor protein 4. (630 aa)
SHC2Uncharacterized protein. (516 aa)
SHC3SHC adaptor protein 3. (598 aa)
H2BW2H2B histone family member M; Belongs to the histone H2B family. (153 aa)
GNB4G protein subunit beta 4. (340 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CALML6Calmodulin like 6. (181 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (301 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (165 aa)
GNB1G protein subunit beta 1. (340 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
SLC29A2Solute carrier family 29 member 2. (462 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SLC29A3Solute carrier family 29 member 3. (475 aa)
ATF4Activating transcription factor 4. (351 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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