STRINGSTRING
TGFB1 TGFB1 IL12B IL12B HLA-DPA1 HLA-DPA1 ENSMFAP00000001843 ENSMFAP00000001843 NFKB1 NFKB1 IRAK1 IRAK1 TNF TNF LOC102140782 LOC102140782 IFNGR2 IFNGR2 MAPK1 MAPK1 TGFB2 TGFB2 MAPK11 MAPK11 CYBB CYBB ITGB2 ITGB2 NCF2 NCF2 ITGA4 ITGA4 HLA-DRB5 HLA-DRB5 FCGR1A FCGR1A DQB1 DQB1 LOC102124047 LOC102124047 LOC102139130 LOC102139130 LOC102135686 LOC102135686 TLR2 TLR2 FOS FOS ENSMFAP00000011401 ENSMFAP00000011401 NFKBIA NFKBIA MARCKSL1 MARCKSL1 ENSMFAP00000011903 ENSMFAP00000011903 TGFB3 TGFB3 PTGS2 PTGS2 PRKCB PRKCB ITGAM ITGAM HLA-DRA HLA-DRA TAB1 TAB1 CYBA CYBA NOS2 NOS2 IRAK4 IRAK4 IL12A IL12A ENSMFAP00000020718 ENSMFAP00000020718 PTPN6 PTPN6 RELA RELA IL1A IL1A IL1B IL1B LOC102140945 LOC102140945 IFNG IFNG C3 C3 EEF1A1 EEF1A1 MYD88 MYD88 EEF1A2 EEF1A2 MAPK3 MAPK3 LOC102118733 LOC102118733 TAB2 TAB2 NFKBIB NFKBIB STAT1 STAT1 IL4 IL4 IL10 IL10 ENSMFAP00000033644 ENSMFAP00000033644 NCF4 NCF4 JAK1 JAK1 HLA-DOB HLA-DOB LOC102128954 LOC102128954 JAK2 JAK2 IFNGR1 IFNGR1 LOC102140649 LOC102140649 ENSMFAP00000035747 ENSMFAP00000035747 ITGB1 ITGB1 MAPK14 MAPK14 NCF1 NCF1 FCGR2B FCGR2B MAP3K7 MAP3K7 ELK1 ELK1 TRAF6 TRAF6 HLA-DOA HLA-DOA TLR4 TLR4 ENSMFAP00000043481 ENSMFAP00000043481 CR1L CR1L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
ENSMFAP00000001843Ig-like domain-containing protein. (181 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (662 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
LOC102140782Ig-like domain-containing protein. (325 aa)
IFNGR2Interferon gamma receptor 2. (336 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
ITGB2Integrin beta. (874 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
HLA-DRB5Ig-like domain-containing protein. (286 aa)
FCGR1AUncharacterized protein. (375 aa)
DQB1Ig-like domain-containing protein. (156 aa)
LOC102124047Ig-like domain-containing protein. (217 aa)
LOC102139130Ig-like domain-containing protein. (118 aa)
LOC102135686Ig-like domain-containing protein. (191 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ENSMFAP00000011401ETS domain-containing protein. (426 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
MARCKSL1MARCKS like 1. (195 aa)
ENSMFAP00000011903Ig-like domain-containing protein. (133 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1147 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1218 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
ENSMFAP00000020718Ig-like domain-containing protein. (193 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (271 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
LOC102140945Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Binds IgG1 and IgG2 (By similarity). (277 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
C3Complement C3. (1663 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
LOC102118733Ig-like domain-containing protein. (192 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
ENSMFAP00000033644Ig-like domain-containing protein. (192 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
LOC102128954Ig-like domain-containing protein. (191 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
IFNGR1Uncharacterized protein. (488 aa)
LOC102140649Ig-like domain-containing protein. (263 aa)
ENSMFAP00000035747Ig-like domain-containing protein. (198 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
FCGR2BUncharacterized protein. (317 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ELK1ETS domain-containing protein Elk-1. (428 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa)
ENSMFAP00000043481Tr-type G domain-containing protein. (453 aa)
CR1LComplement C3b/C4b receptor 1 like. (568 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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