Your Input: | |
| | IL10RB | Interleukin 10 receptor subunit beta. (313 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | HLA-DPA1 | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (662 aa) |
| | STAT3 | Signal transducer and activator of transcription. (802 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | LOC102140782 | Ig-like domain-containing protein. (325 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (336 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | LAMB1 | Laminin subunit beta 1. (1810 aa) |
| | LY96 | MD2 protein. (160 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | HLA-DRB5 | Ig-like domain-containing protein. (286 aa) |
| | GNAI1 | G protein subunit alpha i1. (422 aa) |
| | LAMC2 | Laminin subunit gamma 2. (1301 aa) |
| | PIK3R6 | Phosphoinositide-3-kinase regulatory subunit 6. (750 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (215 aa) |
| | DQB1 | Ig-like domain-containing protein. (156 aa) |
| | BCL2 | BCL2 apoptosis regulator. (242 aa) |
| | LAMA1 | Laminin subunit alpha 1. (3079 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | ENSMFAP00000011991 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (674 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | LOC102120841 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | ENSMFAP00000013592 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | CYCS | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | ENSMFAP00000014202 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (571 aa) |
| | LOC102117102 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) |
| | ENSMFAP00000014371 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) |
| | LAMB2 | Laminin subunit beta 2. (1798 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | HLA-DRA | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1218 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | CD40 | CD40 molecule. (278 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | PIK3CG | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | HSPA2 | Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (641 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (421 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | TYK2 | Tyrosine-protein kinase. (1190 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (298 aa) |
| | LAMA3 | Laminin subunit alpha 3. (3333 aa) |
| | CIITA | Class II major histocompatibility complex transactivator. (1122 aa) |
| | PIK3R5 | Phosphoinositide-3-kinase regulatory subunit 5. (881 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | CD40LG | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | LDLR | Low density lipoprotein receptor. (860 aa) |
| | TNFRSF1A | Uncharacterized protein. (455 aa) |
| | LAMC3 | Laminin subunit gamma 3. (1070 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (398 aa) |
| | LAMC1 | Laminin subunit gamma 1. (1608 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | LAMA4 | Laminin subunit alpha 4. (1823 aa) |
| | CCR5 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (379 aa) |
| | STAT1 | Signal transducer and activator of transcription. (758 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | LAMB3 | Laminin subunit beta 3. (1094 aa) |
| | LAMB4 | Laminin subunit beta 4. (1762 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | JAK1 | Tyrosine-protein kinase. (1159 aa) |
| | HLA-DOB | Major histocompatibility complex, class II, DO beta. (273 aa) |
| | JAK2 | Tyrosine-protein kinase. (1139 aa) |
| | IFNGR1 | Uncharacterized protein. (488 aa) |
| | LOC102140649 | Ig-like domain-containing protein. (263 aa) |
| | CASP8 | Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa) |
| | ITGB1 | Integrin beta; Belongs to the integrin beta chain family. (801 aa) |
| | GNAI3 | G protein subunit alpha i3. (354 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (576 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ITGA6 | Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa) |
| | HSPA8 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | PPIF | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa) |
| | LAMA5 | Laminin subunit alpha 5. (3699 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | MAP2K6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (334 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (497 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa) |
| | LAMA2 | Laminin subunit alpha 2. (3122 aa) |
| | HSPA1L | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] (643 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
