STRINGSTRING
C8B C8B TGFB1 TGFB1 PIK3R3 PIK3R3 PIK3CD PIK3CD IL12B IL12B PLCB4 PLCB4 ENSMFAP00000001843 ENSMFAP00000001843 NFKB1 NFKB1 CTSG CTSG TNF TNF ACTN4 ACTN4 CXCL8 CXCL8 PTK2 PTK2 COL4A2 COL4A2 LAMB1 LAMB1 RAB5A RAB5A TGFB2 TGFB2 PIK3CB PIK3CB CXCL2 CXCL2 COL4A3 COL4A3 RAB7A RAB7A ITGB2 ITGB2 C8A C8A LAMC2 LAMC2 ARG2 ARG2 ENSMFAP00000009633 ENSMFAP00000009633 PRKACA PRKACA CXCL3 CXCL3 LOC102124047 LOC102124047 LOC102139130 LOC102139130 LAMA1 LAMA1 LOC102135686 LOC102135686 TLR2 TLR2 ENSMFAP00000011903 ENSMFAP00000011903 CSF2 CSF2 TGFB3 TGFB3 CD14 CD14 PRKCA PRKCA PRDX1 PRDX1 RAB5B RAB5B PRKACG PRKACG LAMB2 LAMB2 PRKCB PRKCB ITGAM ITGAM CD1B CD1B COL4A5 COL4A5 CD1C CD1C RAB7B RAB7B FN1 FN1 NOS2 NOS2 IL12A IL12A COL4A6 COL4A6 CD1E CD1E ENSMFAP00000020718 ENSMFAP00000020718 RELA RELA LOC102131730 LOC102131730 SERPINB10 SERPINB10 GNA14 GNA14 IL1B IL1B LOC102135631 LOC102135631 PLCB1 PLCB1 GNAS GNAS IFNG IFNG SERPINB6 SERPINB6 PRKACB PRKACB CD1D CD1D GNAL GNAL LOC102135021 LOC102135021 SERPINB13 SERPINB13 CD1A CD1A CXCL3-2 CXCL3-2 VCL VCL PLCB3 PLCB3 PIK3CA PIK3CA PIK3R1 PIK3R1 HSPB1 HSPB1 LAMA3 LAMA3 ARG1 ARG1 COL1A2 COL1A2 LOC102118733 LOC102118733 SERPINB9 SERPINB9 LAMC3 LAMC3 PRKCG PRKCG LAMC1 LAMC1 CASP3 CASP3 LAMA4 LAMA4 PLCB2 PLCB2 IL10 IL10 LAMB3 LAMB3 LAMB4 LAMB4 ENSMFAP00000033644 ENSMFAP00000033644 ACTN1 ACTN1 COL4A1 COL4A1 COL3A1 COL3A1 LOC102128954 LOC102128954 GNAQ GNAQ COL1A1 COL1A1 ENSMFAP00000035747 ENSMFAP00000035747 IL1R1 IL1R1 PIK3R2 PIK3R2 CXCL1L CXCL1L ADCY1 ADCY1 IL1R2 IL1R2 C8G C8G GNA11 GNA11 LAMA5 LAMA5 TLR4 TLR4 C9 C9 LAMA2 LAMA2 CXCL1 CXCL1 RAB5C RAB5C IL6 IL6 GNA15 GNA15 COL4A4 COL4A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C8BComplement C8 beta chain. (591 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ENSMFAP00000001843Ig-like domain-containing protein. (181 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ACTN4Actinin alpha 4. (931 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
COL4A2Collagen type IV alpha 2 chain. (1724 aa)
LAMB1Laminin subunit beta 1. (1810 aa)
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
CXCL2C-X-C motif chemokine. (107 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
ITGB2Integrin beta. (874 aa)
C8AComplement C8 alpha chain. (584 aa)
LAMC2Laminin subunit gamma 2. (1301 aa)
ARG2Arginase. (354 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CXCL3C-X-C motif chemokine. (107 aa)
LOC102124047Ig-like domain-containing protein. (217 aa)
LOC102139130Ig-like domain-containing protein. (118 aa)
LAMA1Laminin subunit alpha 1. (3079 aa)
LOC102135686Ig-like domain-containing protein. (191 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
ENSMFAP00000011903Ig-like domain-containing protein. (133 aa)
CSF2Colony stimulating factor 2. (144 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CD14Uncharacterized protein. (384 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PRDX1Thioredoxin domain-containing protein. (199 aa)
RAB5BUncharacterized protein. (221 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1147 aa)
CD1BCD1b molecule. (333 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
CD1CCD1c molecule. (332 aa)
RAB7BRAB7B, member RAS oncogene family. (189 aa)
FN1Fibronectin 1. (2477 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1218 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
CD1ECD1e molecule. (426 aa)
ENSMFAP00000020718Ig-like domain-containing protein. (193 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
LOC102131730SERPIN domain-containing protein; Belongs to the serpin family. (382 aa)
SERPINB10Serpin family B member 10; Belongs to the serpin family. (397 aa)
GNA14G protein subunit alpha 14. (355 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
LOC102135631SERPIN domain-containing protein; Belongs to the serpin family. (379 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNASGNAS complex locus. (1023 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
SERPINB6Serpin B6; Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). (395 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CD1DCD1d molecule. (337 aa)
GNALG protein subunit alpha L. (450 aa)
LOC102135021SERPIN domain-containing protein; Belongs to the serpin family. (390 aa)
SERPINB13Serpin family B member 13; Belongs to the serpin family. (400 aa)
CD1ACD1a molecule. (327 aa)
CXCL3-2C-X-C motif chemokine. (107 aa)
VCLUncharacterized protein. (80 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
ARG1Arginase. (322 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
LOC102118733Ig-like domain-containing protein. (192 aa)
SERPINB9Serpin family B member 9; Belongs to the serpin family. (376 aa)
LAMC3Laminin subunit gamma 3. (1070 aa)
PRKCGProtein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
LAMB3Laminin subunit beta 3. (1094 aa)
LAMB4Laminin subunit beta 4. (1762 aa)
ENSMFAP00000033644Ig-like domain-containing protein. (192 aa)
ACTN1Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (914 aa)
COL4A1Collagen type IV alpha 1 chain. (1607 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
LOC102128954Ig-like domain-containing protein. (191 aa)
GNAQG protein subunit alpha q. (359 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
ENSMFAP00000035747Ig-like domain-containing protein. (198 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
PIK3R2Uncharacterized protein. (694 aa)
CXCL1LC-X-C motif chemokine. (154 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
C8GComplement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
GNA11G protein subunit alpha 11. (359 aa)
LAMA5Laminin subunit alpha 5. (3699 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa)
C9Complement C9. (561 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
CXCL1C-X-C motif chemokine. (107 aa)
RAB5CRAB5C, member RAS oncogene family. (249 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (212 aa)
GNA15G protein subunit alpha 15. (330 aa)
COL4A4Collagen type IV alpha 4 chain. (1692 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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