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| | IL10RB | Interleukin 10 receptor subunit beta. (313 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | NFYB | CBFD_NFYB_HMF domain-containing protein. (208 aa) |
| | NFYC | Nuclear transcription factor Y subunit gamma. (439 aa) |
| | IL23A | Interleukin 23 p19 subunit. (189 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (535 aa) |
| | MRC1 | Mannose receptor C-type 1. (1456 aa) |
| | EEA1 | Early endosome antigen 1. (1453 aa) |
| | HLA-DPA1 | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa) |
| | ENSMFAP00000001843 | Ig-like domain-containing protein. (181 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (662 aa) |
| | RHOA | Uncharacterized protein. (141 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (233 aa) |
| | LOC102140782 | Ig-like domain-containing protein. (325 aa) |
| | CYP27B1 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (336 aa) |
| | LOC102141352 | Uncharacterized protein. (198 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (625 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | RAB5A | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (557 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | CALM3 | Calmodulin 1; Belongs to the calmodulin family. (149 aa) |
| | RAB7A | RAB7A, member RAS oncogene family. (207 aa) |
| | CALML4 | Calmodulin like 4. (193 aa) |
| | ITGB2 | Integrin beta. (874 aa) |
| | CAMK2D | Protein kinase domain-containing protein. (533 aa) |
| | CD74 | CD74 molecule. (294 aa) |
| | SPHK2 | Sphingosine kinase 2. (653 aa) |
| | HLA-DRB5 | Ig-like domain-containing protein. (286 aa) |
| | LOC102141744 | Uncharacterized protein. (198 aa) |
| | FCGR1A | Uncharacterized protein. (375 aa) |
| | DQB1 | Ig-like domain-containing protein. (156 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (438 aa) |
| | LOC102124047 | Ig-like domain-containing protein. (217 aa) |
| | LOC102139130 | Ig-like domain-containing protein. (118 aa) |
| | BCL2 | BCL2 apoptosis regulator. (242 aa) |
| | CALML3 | Calmodulin like 3; Belongs to the calmodulin family. (149 aa) |
| | LOC102135686 | Ig-like domain-containing protein. (191 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (787 aa) |
| | LOC102140303 | Uncharacterized protein. (190 aa) |
| | IFNA6 | Interferon alpha 6. (190 aa) |
| | ENSMFAP00000011903 | Ig-like domain-containing protein. (133 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | ENSMFAP00000011991 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | CD14 | Uncharacterized protein. (384 aa) |
| | LOC102120841 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | LAMP2 | Lysosomal associated membrane protein 2. (411 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (187 aa) |
| | ENSMFAP00000013592 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | LOC102146717 | Uncharacterized protein. (189 aa) |
| | TLR1 | Toll-like receptor. (786 aa) |
| | CYCS | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | RAB5B | Uncharacterized protein. (221 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (150 aa) |
| | LOC102117102 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) |
| | ENSMFAP00000014371 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa) |
| | CORO1A | Coronin-1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. (461 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1147 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (423 aa) |
| | PPP3R1 | Uncharacterized protein. (189 aa) |
| | CLEC7A | C-type lectin domain containing 7A. (281 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | HLA-DRA | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa) |
| | SPHK1 | Sphingosine kinase 1. (470 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1218 aa) |
| | ITGAX | Integrin subunit alpha X; Belongs to the integrin alpha chain family. (1168 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | CAMP | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. (173 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (520 aa) |
| | HSPD1 | Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (598 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | ENSMFAP00000020718 | Ig-like domain-containing protein. (193 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | LBP | Lipopolysaccharide binding protein. (481 aa) |
| | RFX5 | RFX-type winged-helix domain-containing protein. (620 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (271 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) |
| | LOC102140945 | Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Binds IgG1 and IgG2 (By similarity). (277 aa) |
| | RFXAP | Regulatory factor X associated protein. (272 aa) |
| | FCER1G | High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functi [...] (112 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa) |
| | ATP6V0C | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (128 aa) |
| | CLEC4E | C-type lectin domain family 4 member E. (219 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (421 aa) |
| | C3 | Complement C3. (1663 aa) |
| | BID | BH3 interacting domain death agonist. (244 aa) |
| | HSPA9 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (679 aa) |
| | ATP6V0B | ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (259 aa) |
| | CIITA | Class II major histocompatibility complex transactivator. (1122 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | PLA2R1 | Phospholipase A2 receptor 1. (1466 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | LOC102118733 | Ig-like domain-containing protein. (192 aa) |
| | TIRAP | TIR domain-containing protein. (234 aa) |
| | TNFRSF1A | Uncharacterized protein. (455 aa) |
| | MALT1 | MALT1 paracaspase. (824 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (398 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) |
| | STAT1 | Signal transducer and activator of transcription. (758 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | ENSMFAP00000033644 | Ig-like domain-containing protein. (192 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | JAK1 | Tyrosine-protein kinase. (1159 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (470 aa) |
| | HLA-DOB | Major histocompatibility complex, class II, DO beta. (273 aa) |
| | LOC102128954 | Ig-like domain-containing protein. (191 aa) |
| | JAK2 | Tyrosine-protein kinase. (1139 aa) |
| | RFXANK | Regulatory factor X associated ankyrin containing protein. (260 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | IFNGR1 | Uncharacterized protein. (488 aa) |
| | LOC102140649 | Ig-like domain-containing protein. (263 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa) |
| | ENSMFAP00000035747 | Ig-like domain-containing protein. (198 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | CASP8 | Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa) |
| | LSP1 | Lymphocyte specific protein 1. (453 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1117 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (576 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | FCGR2B | Uncharacterized protein. (317 aa) |
| | VDR | Vitamin D receptor. (477 aa) |
| | CTSS | Cathepsin S; Belongs to the peptidase C1 family. (331 aa) |
| | NFYA | Nuclear transcription factor Y subunit alpha. (347 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (552 aa) |
| | CALML6 | Calmodulin like 6. (181 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (664 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | MRC2 | Mannose receptor C type 2. (1479 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | RAB5C | RAB5C, member RAS oncogene family. (249 aa) |
| | EP300 | E1A binding protein p300. (2414 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (212 aa) |
| | CR1L | Complement C3b/C4b receptor 1 like. (568 aa) |
