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| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | NFYB | CBFD_NFYB_HMF domain-containing protein. (208 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | CCNB2 | G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (398 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | CALR | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. (417 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | TSPO | Translocator protein. (169 aa) |
| | HLA-E | Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (382 aa) |
| | KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa) |
| | HLA-DPA1 | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa) |
| | HLA-F | Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (443 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (947 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | CD3E | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (198 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa) |
| | LOC102140782 | Ig-like domain-containing protein. (325 aa) |
| | CDC20 | WD_REPEATS_REGION domain-containing protein. (499 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | TSPO2 | Translocator protein 2. (170 aa) |
| | ADCY2 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | ETS1 | ETS proto-oncogene 1, transcription factor. (485 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | LOC102125623 | Ig-like domain-containing protein; Belongs to the MHC class I family. (389 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | LOC102119088 | Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (356 aa) |
| | IL2RB | Interleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). (551 aa) |
| | VDAC1 | Uncharacterized protein. (289 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (755 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (918 aa) |
| | ITGB2 | Integrin beta. (874 aa) |
| | SLC25A5 | Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | ATF6B | Activating transcription factor 6 beta. (708 aa) |
| | HLA-DRB5 | Ig-like domain-containing protein. (286 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) |
| | ZFP36 | ZFP36 ring finger protein. (332 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (488 aa) |
| | RB1 | RB transcriptional corepressor 1. (928 aa) |
| | PRKACA | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa) |
| | DQB1 | Ig-like domain-containing protein. (156 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (438 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1683 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | ENSMFAP00000011401 | ETS domain-containing protein. (426 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (812 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (168 aa) |
| | CSF2 | Colony stimulating factor 2. (144 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | ICAM1 | Intercellular adhesion molecule 1. (532 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa) |
| | PRKACG | Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (599 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (519 aa) |
| | TBP | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase [...] (326 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (899 aa) |
| | TBPL2 | TATA-box binding protein like 2. (376 aa) |
| | ESPL1 | Extra spindle pole bodies like 1, separase. (2120 aa) |
| | LCK | Tyrosine-protein kinase. (342 aa) |
| | PPP3R1 | Uncharacterized protein. (189 aa) |
| | LTA | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa) |
| | RANBP3 | Ran-binding protein 3; Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity). (567 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | IL2RA | Interleukin 2 receptor alpha. (272 aa) |
| | CANX | Calnexin. (592 aa) |
| | SLC2A1 | Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa) |
| | Mafa-B | MHC_I-like_Ag-recog domain-containing protein. (139 aa) |
| | BUB1B | BUB1 N-terminal domain-containing protein. (1050 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | HLA-DRA | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | TNFRSF13C | TNF receptor superfamily member 13C. (184 aa) |
| | RELB | RELB proto-oncogene, NF-kB subunit. (526 aa) |
| | LOC102114865 | Ig-like domain-containing protein; Belongs to the MHC class I family. (244 aa) |
| | TCF3 | Transcription factor 3. (654 aa) |
| | SLC25A4 | Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (520 aa) |
| | CD40 | CD40 molecule. (278 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (923 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | ELK4 | ETS transcription factor ELK4. (431 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa) |
| | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3. (657 aa) |
| | GPS2 | G protein pathway suppressor 2. (327 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (520 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa) |
| | KAT2B | Lysine acetyltransferase 2B. (731 aa) |
| | CCNA1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (465 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | EGR2 | Early growth response 2. (489 aa) |
| | SRF | Serum response factor. (508 aa) |
| | CRTC3 | CREB regulated transcription coactivator 3. (619 aa) |
| | SLC25A6 | Solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | TLN1 | Talin 1. (2556 aa) |
| | IL2RG | Fibronectin type-III domain-containing protein. (369 aa) |
| | LTBR | Lymphotoxin beta receptor. (435 aa) |
| | CDKN2A | ANK_REP_REGION domain-containing protein. (160 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | MAD2L1 | Mitotic spindle assembly checkpoint protein MAD2. (205 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1060 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa) |
| | CDC27 | Cell division cycle 27. (830 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (372 aa) |
| | BUB3 | BUB3, mitotic checkpoint protein. (328 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (925 aa) |
| | LOC102123548 | Ig-like domain-containing protein; Belongs to the MHC class I family. (363 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | LOC102141835 | Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa) |
| | IL15RA | Interleukin 15 receptor subunit alpha. (253 aa) |
| | CRTC1 | CREB regulated transcription coactivator 1. (628 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | FOSL1 | FOS like 1, AP-1 transcription factor subunit. (271 aa) |
| | CD3D | T-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (171 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | VDAC3 | Voltage dependent anion channel 3. (284 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | TNFRSF1A | Uncharacterized protein. (455 aa) |
| | CDC16 | Cell division cycle 16. (526 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | ETS2 | Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (398 aa) |
| | NRAS | Uncharacterized protein. (189 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | FDPS | Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (419 aa) |
| | ADCY5 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa) |
| | ITGAL | VWFA domain-containing protein. (582 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | JAK1 | Tyrosine-protein kinase. (1159 aa) |
| | E2F3 | E2F transcription factor 3. (335 aa) |
| | HLA-DOB | Major histocompatibility complex, class II, DO beta. (273 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | LOC102140649 | Ig-like domain-containing protein. (263 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (569 aa) |
| | JAK3 | Tyrosine-protein kinase. (1124 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | PIK3R2 | Uncharacterized protein. (694 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | MMP7 | Matrix metallopeptidase 7. (270 aa) |
| | TLN2 | Talin 2. (2544 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa) |
| | SLC25A31 | ADP/ATP translocase 4; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility (By similarity). (315 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa) |
| | ANAPC4 | Anaphase promoting complex subunit 4. (981 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa) |
| | XPO1 | Exportin 1. (1071 aa) |
| | ENSMFAP00000038879 | GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (206 aa) |
| | VDAC2 | Uncharacterized protein. (308 aa) |
| | PTTG1 | PTTG1 regulator of sister chromatid separation, securin. (202 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (718 aa) |
| | RANBP1 | RAN binding protein 1. (278 aa) |
| | LOC102132794 | Ig-like domain-containing protein; Belongs to the MHC class I family. (334 aa) |
| | CRTC2 | CREB regulated transcription coactivator 2. (694 aa) |
| | IL1R2 | Interleukin 1 receptor type 2. (398 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | ELK1 | ETS domain-containing protein Elk-1. (428 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (301 aa) |
| | CD3G | T-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (181 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | VAC14 | VAC14 component of PIKFYVE complex. (782 aa) |
| | TBPL1 | TATA box-binding protein-like protein 1; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). (186 aa) |
| | MSX2 | Msh homeobox 2. (267 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (497 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1944 aa) |
| | MSX1 | Msh homeobox 1. (303 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | ADCY4 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa) |
| | EP300 | E1A binding protein p300. (2414 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (212 aa) |
| | ATF4 | Activating transcription factor 4. (351 aa) |
| | TRRAP | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3859 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
