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| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | CCNB2 | G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (398 aa) |
| | CALR | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. (417 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | HLA-E | Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (382 aa) |
| | HLA-F | Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (443 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (662 aa) |
| | CD3E | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (198 aa) |
| | GNGT1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | AP1S2 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa) |
| | STING1 | Stimulator of interferon protein. (379 aa) |
| | LOC102141352 | Uncharacterized protein. (198 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | RNF7 | Ring finger protein 7. (113 aa) |
| | LOC102125623 | Ig-like domain-containing protein; Belongs to the MHC class I family. (389 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | ENSMFAP00000006047 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | BST2 | Bone marrow stromal cell antigen 2. (182 aa) |
| | GNG4 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | CALM3 | Calmodulin 1; Belongs to the calmodulin family. (149 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa) |
| | CALML4 | Calmodulin like 4. (193 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (918 aa) |
| | SAMHD1 | SAM domain and HD domain-containing protein. (626 aa) |
| | CFL2 | Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | LOC102141744 | Uncharacterized protein. (198 aa) |
| | GNAI1 | G protein subunit alpha i1. (422 aa) |
| | GNGT2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa) |
| | TAPBP | TAP binding protein. (504 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (488 aa) |
| | RAC3 | Rac family small GTPase 3. (180 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (438 aa) |
| | BTRC | Uncharacterized protein. (605 aa) |
| | BCL2 | BCL2 apoptosis regulator. (242 aa) |
| | CALML3 | Calmodulin like 3; Belongs to the calmodulin family. (149 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | LOC102140303 | Uncharacterized protein. (190 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | APOBEC3C | CMP/dCMP-type deaminase domain-containing protein. (190 aa) |
| | IFNA6 | Interferon alpha 6. (190 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | ENSMFAP00000011991 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa) |
| | LOC102142638 | Protein kinase domain-containing protein. (297 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (812 aa) |
| | ELOB | Elongin B. (162 aa) |
| | LOC102120841 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | PAK4 | Non-specific serine/threonine protein kinase. (600 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (187 aa) |
| | ENSMFAP00000013592 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | LOC102146717 | Uncharacterized protein. (189 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | CYCS | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | GNB3 | G protein subunit beta 3. (340 aa) |
| | LOC102117102 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) |
| | GNG5 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | ENSMFAP00000014371 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) |
| | AP1S1 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa) |
| | RPS6KB2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa) |
| | PXN | Paxillin. (1079 aa) |
| | PPP3R1 | Uncharacterized protein. (189 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | APOBEC3H | Apolipoprotein B mRNA editing enzyme catalytic subunit 3H. (211 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | Mafa-B | MHC_I-like_Ag-recog domain-containing protein. (139 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | LOC102114865 | Ig-like domain-containing protein; Belongs to the MHC class I family. (244 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (520 aa) |
| | PAK6 | Non-specific serine/threonine protein kinase. (681 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa) |
| | GNG11 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa) |
| | CCNB3 | Cyclin B3; Belongs to the cyclin family. (1363 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa) |
| | AP1M1 | AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (435 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (463 aa) |
| | GNG12 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (759 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1060 aa) |
| | TRIM5 | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (495 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (421 aa) |
| | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the p [...] (456 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (925 aa) |
| | LOC102123548 | Ig-like domain-containing protein; Belongs to the MHC class I family. (363 aa) |
| | BID | BH3 interacting domain death agonist. (244 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | LOC102141835 | Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | CD3D | T-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (171 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | CFL1 | Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity); Belongs to the actin-binding proteins ADF family. (196 aa) |
| | LIMK1 | LIM domain kinase 1. (677 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | TNFRSF1A | Uncharacterized protein. (455 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1147 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (913 aa) |
| | LIMK2 | LIM domain kinase 2. (638 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (398 aa) |
| | PRKCG | Protein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa) |
| | NRAS | Uncharacterized protein. (189 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) |
| | CXCR4 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (408 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | TAP2 | Transporter 2, ATP binding cassette subfamily B member. (703 aa) |
| | CCR5 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (379 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (545 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | GNB5 | G protein subunit beta 5. (409 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa) |
| | GNAQ | G protein subunit alpha q. (359 aa) |
| | APOBEC3F | Apolipoprotein B mRNA editing enzyme catalytic subunit 3F. (373 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa) |
| | PIK3R2 | Uncharacterized protein. (694 aa) |
| | WEE1 | Wee1-like protein kinase. (646 aa) |
| | CASP8 | Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa) |
| | GNG2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa) |
| | GNAI3 | G protein subunit alpha i3. (354 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | AP1G1 | AP-1 complex subunit gamma. (817 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ELOC | Elongin C; Belongs to the SKP1 family. (112 aa) |
| | AP1G2 | AP-1 complex subunit gamma. (785 aa) |
| | CUL5 | Cullin 5; Belongs to the cullin family. (780 aa) |
| | WEE2 | Wee1-like protein kinase. (568 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | LOC102132794 | Ig-like domain-containing protein; Belongs to the MHC class I family. (334 aa) |
| | PAK5 | Non-specific serine/threonine protein kinase. (719 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | CGAS | Cyclic GMP-AMP synthase. (522 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa) |
| | GNA11 | G protein subunit alpha 11. (359 aa) |
| | TAP1 | Transporter 1, ATP binding cassette subfamily B member. (808 aa) |
| | GNB4 | G protein subunit beta 4. (340 aa) |
| | GNG10 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa) |
| | CALML6 | Calmodulin like 6. (181 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | CD3G | T-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (181 aa) |
| | FBXW11 | F-box and WD repeat domain containing 11. (542 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa) |
| | MAP2K6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (334 aa) |
| | RBX1 | RING-box protein 1. (108 aa) |
| | GNB1 | G protein subunit beta 1. (340 aa) |
| | PAK3 | P21 (RAC1) activated kinase 3. (580 aa) |
| | AP1B1 | AP complex subunit beta. (949 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (167 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | GNG3 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | CDK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa) |
| | AP1S3 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (164 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1493 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (524 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
