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HDAC2 HDAC2 CCND3 CCND3 UBR4 UBR4 PIK3R3 PIK3R3 GTF2A1 GTF2A1 CCND1 CCND1 PIK3CD PIK3CD CCND2 CCND2 UBE3A UBE3A HRAS HRAS SNW1 SNW1 HLA-E HLA-E KAT2A KAT2A HLA-F HLA-F GRB2 GRB2 HNRNPK HNRNPK IL6ST IL6ST LOC102121517 LOC102121517 NFKB1 NFKB1 RHOA RHOA DLG1 DLG1 CREB5 CREB5 H2BC13 H2BC13 HDAC10 HDAC10 STAT3 STAT3 HDAC11 HDAC11 ACTN4 ACTN4 CDC20 CDC20 CDKN1A CDKN1A YWHAZ YWHAZ RBPJ RBPJ LOC102137233 LOC102137233 MAPK1 MAPK1 CDK6 CDK6 LOC102125623 LOC102125623 ATF2 ATF2 GTF2E1 GTF2E1 HDAC3 HDAC3 PIK3CB PIK3CB ATF6B ATF6B GTF2H2 GTF2H2 HDAC1 HDAC1 CHEK1 CHEK1 GTF2B GTF2B HIST1H2BO HIST1H2BO RB1 RB1 PRKACA PRKACA H2BC14 H2BC14 YWHAQ YWHAQ DDX3X DDX3X ENSMFAP00000010040 ENSMFAP00000010040 H2BC1 H2BC1 LOC102136612 LOC102136612 H2BC11 H2BC11 G7P2P1_MACFA G7P2P1_MACFA CCR4 CCR4 HDAC9 HDAC9 NFKBIA NFKBIA LOC102142638 LOC102142638 H2BU1 H2BU1 GTF2H4 GTF2H4 STAT5A STAT5A H2BC5 H2BC5 SCIN SCIN G8F2Z2_MACFA G8F2Z2_MACFA BAK1 BAK1 H2BC3 H2BC3 HIST2H2BE HIST2H2BE PRKACG PRKACG ENSMFAP00000014622 ENSMFAP00000014622 SKP2 SKP2 EIF2AK2 EIF2AK2 RASA2 RASA2 RBL1 RBL1 POLB POLB CREB3L1 CREB3L1 TBP TBP NFKB2 NFKB2 TRAF1 TRAF1 TBPL2 TBPL2 PXN PXN GTF2E2 GTF2E2 Mafa-B Mafa-B SRC SRC IKBKG IKBKG CDKN1B CDKN1B LOC102114865 LOC102114865 CDC42 CDC42 TRADD TRADD GTF2H1 GTF2H1 SYK SYK TRAF2 TRAF2 RELA RELA BAX BAX HDAC4 HDAC4 MAPKAPK2 MAPKAPK2 ATP6V0D2 ATP6V0D2 CREB3L2 CREB3L2 LOC102128824 LOC102128824 KAT2B KAT2B CCNA1 CCNA1 BAD BAD EGR2 EGR2 SRF SRF YWHAB YWHAB LYN LYN HDAC5 HDAC5 LTBR LTBR CDKN2A CDKN2A CDK4 CDK4 HDAC6 HDAC6 PRKACB PRKACB ENSMFAP00000025317 ENSMFAP00000025317 HDAC7 HDAC7 PKM PKM C3 C3 CDK2 CDK2 PMAIP1 PMAIP1 CREB3 CREB3 ENSMFAP00000027000 ENSMFAP00000027000 YWHAH YWHAH LOC102123548 LOC102123548 PIK3CA PIK3CA TRAF3 TRAF3 LOC102141835 LOC102141835 PIK3R1 PIK3R1 VDAC3 VDAC3 MAPK3 MAPK3 DDB1 DDB1 SCRIB SCRIB DNAJA3 DNAJA3 MDM2 MDM2 LOC102133669 LOC102133669 NRAS NRAS CASP3 CASP3 CCR3 CCR3 CCR5 CCR5 PSMC1 PSMC1 HDAC8 HDAC8 H2BC18 H2BC18 CHD4 CHD4 JAK1 JAK1 ACTN1 ACTN1 KRAS KRAS MRPS18B MRPS18B JAK3 JAK3 CREBBP CREBBP PIK3R2 PIK3R2 CASP8 CASP8 GTF2A2 GTF2A2 CCNA2 CCNA2 GTF2H3 GTF2H3 SND1 SND1 YWHAG YWHAG TP53 TP53 REL REL EGR3 EGR3 MAD1L1 MAD1L1 RANBP1 RANBP1 LOC102132794 LOC102132794 GSN GSN ENSMFAP00000040719 ENSMFAP00000040719 RBPJL RBPJL HPN HPN CCNE1 CCNE1 H2BW2 H2BW2 IRF7 IRF7 CREB3L3 CREB3L3 H2BC15 H2BC15 VAC14 VAC14 TRAF5 TRAF5 TBPL1 TBPL1 USP7 USP7 RBL2 RBL2 CDK1 CDK1 CREB1 CREB1 EP300 EP300 ATF4 ATF4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
UBR4Ubiquitin protein ligase E3 component n-recognin 4. (5231 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
GTF2A1General transcription factor IIA subunit 1. (376 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SNW1SNW domain containing 1. (571 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (382 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (443 aa)
GRB2Growth factor receptor-binding protein 2. (217 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (464 aa)
IL6STInterleukin 6 signal transducer. (942 aa)
LOC102121517Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (103 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
RHOAUncharacterized protein. (141 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (136 aa)
HDAC10Histone deacetylase 10. (672 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
HDAC11Histone deacetylase 11; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (319 aa)
ACTN4Actinin alpha 4. (931 aa)
CDC20WD_REPEATS_REGION domain-containing protein. (499 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (257 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (529 aa)
LOC102137233Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
LOC102125623Ig-like domain-containing protein; Belongs to the MHC class I family. (389 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
GTF2E1General transcription factor IIE subunit 1. (450 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (488 aa)
GTF2BTranscription initiation factor IIB; General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II- TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter [...] (316 aa)
HIST1H2BOHistone H2B; Belongs to the histone H2B family. (126 aa)
RB1RB transcriptional corepressor 1. (928 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
ENSMFAP00000010040Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC102136612Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
H2BC11Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
G7P2P1_MACFAHistone H2B; Belongs to the histone H2B family. (126 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
LOC102142638Protein kinase domain-containing protein. (297 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
SCINScinderin. (715 aa)
G8F2Z2_MACFAHistone H2B; Belongs to the histone H2B family. (126 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
ENSMFAP00000014622Histone H2B; Belongs to the histone H2B family. (126 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (554 aa)
RASA2RAS p21 protein activator 2. (860 aa)
RBL1RB transcriptional corepressor like 1. (1067 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
TBPTATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase [...] (326 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
TRAF1TNF receptor-associated factor. (416 aa)
TBPL2TATA-box binding protein like 2. (376 aa)
PXNPaxillin. (1079 aa)
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (291 aa)
Mafa-BMHC_I-like_Ag-recog domain-containing protein. (139 aa)
SRCTyrosine-protein kinase. (542 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
LOC102114865Ig-like domain-containing protein; Belongs to the MHC class I family. (244 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
GTF2H1Uncharacterized protein. (548 aa)
SYKTyrosine-protein kinase. (635 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (381 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
LOC102128824Uncharacterized protein. (134 aa)
KAT2BLysine acetyltransferase 2B. (731 aa)
CCNA1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (465 aa)
BADBCL2 associated agonist of cell death. (167 aa)
EGR2Early growth response 2. (489 aa)
SRFSerum response factor. (508 aa)
YWHAB14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] (246 aa)
LYNTyrosine-protein kinase. (512 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1122 aa)
LTBRLymphotoxin beta receptor. (435 aa)
CDKN2AANK_REP_REGION domain-containing protein. (160 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
HDAC6Histone deacetylase 6. (1215 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1008 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
C3Complement C3. (1663 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
PMAIP1Uncharacterized protein. (133 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
ENSMFAP00000027000Pyruvate kinase; Belongs to the pyruvate kinase family. (142 aa)
YWHAH14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
LOC102123548Ig-like domain-containing protein; Belongs to the MHC class I family. (363 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
LOC102141835Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
SCRIBScribble planar cell polarity protein. (1662 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
LOC102133669Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
NRASUncharacterized protein. (189 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
CCR3C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. (376 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (379 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (134 aa)
CHD4Uncharacterized protein. (1912 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
ACTN1Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (914 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MRPS18BUncharacterized protein. (258 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
CREBBPCREB binding protein. (2442 aa)
PIK3R2Uncharacterized protein. (694 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
GTF2H3Uncharacterized protein. (172 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
RELREL proto-oncogene, NF-kB subunit. (616 aa)
EGR3Early growth response 3. (387 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (718 aa)
RANBP1RAN binding protein 1. (278 aa)
LOC102132794Ig-like domain-containing protein; Belongs to the MHC class I family. (334 aa)
GSNGelsolin. (784 aa)
ENSMFAP0000004071914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
HPNHepsin; Belongs to the peptidase S1 family. (471 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
H2BW2H2B histone family member M; Belongs to the histone H2B family. (153 aa)
IRF7Interferon regulatory factor 7. (504 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (301 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (165 aa)
VAC14VAC14 component of PIKFYVE complex. (782 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
TBPL1TATA box-binding protein-like protein 1; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). (186 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1107 aa)
RBL2RB transcriptional corepressor like 2. (1141 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
EP300E1A binding protein p300. (2414 aa)
ATF4Activating transcription factor 4. (351 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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