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| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | ZFPM2 | Zinc finger protein, FOG family member 2. (1151 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | SPRY2 | Protein sprouty homolog 2; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. (338 aa) |
| | GRB2 | Growth factor receptor-binding protein 2. (217 aa) |
| | HNRNPK | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (464 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1335 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | RHOA | Uncharacterized protein. (141 aa) |
| | TNR | Tenascin R. (1358 aa) |
| | STAT3 | Signal transducer and activator of transcription. (802 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | IGF2BP1 | Insulin like growth factor 2 mRNA binding protein 1. (583 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa) |
| | TNN | Tenascin N. (1299 aa) |
| | PDCD4 | Programmed cell death 4. (471 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | TNC | Tenascin C. (2205 aa) |
| | TNXB | Uncharacterized protein. (4244 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa) |
| | EFNA4 | Ephrin A4; Belongs to the ephrin family. (201 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | TRIM71 | Tripartite motif containing 71. (868 aa) |
| | NOTCH2 | Notch receptor 2. (2610 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | FSCN1 | Fascin. (493 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (215 aa) |
| | BCL2 | BCL2 apoptosis regulator. (242 aa) |
| | PAK4 | Non-specific serine/threonine protein kinase. (600 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1632 aa) |
| | MET | MET proto-oncogene, receptor tyrosine kinase. (1404 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2. (604 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | TIMP3 | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15 (By similarity). (211 aa) |
| | ZEB2 | Zinc finger E-box binding homeobox 2. (1253 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa) |
| | TPM1 | Uncharacterized protein; Belongs to the tropomyosin family. (326 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa) |
| | HOXD10 | Homeobox D10. (340 aa) |
| | MMP9 | Matrix metallopeptidase 9. (707 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa) |
| | SOX4 | Transcription factor SOX. (474 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa) |
| | RDX | FERM domain-containing protein. (604 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (808 aa) |
| | RASSF1 | Ras association domain family member 1. (340 aa) |
| | THBS1 | Thrombospondin 1. (1173 aa) |
| | ST14 | Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa) |
| | NOTCH4 | Notch receptor 4. (2000 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (233 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa) |
| | CCNG1 | Cyclin G1; Belongs to the cyclin family. (295 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | HMGA2 | High mobility group AT-hook 2. (147 aa) |
| | SLC7A1 | Solute carrier family 7 member 1. (629 aa) |
| | HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1122 aa) |
| | RECK | Reversion inducing cysteine rich protein with kazal motifs. (962 aa) |
| | CDKN2A | ANK_REP_REGION domain-containing protein. (160 aa) |
| | CD44 | CD44 molecule (Indian blood group). (742 aa) |
| | ENSMFAP00000025317 | Hist_deacetyl domain-containing protein. (258 aa) |
| | GLS | Glutaminase. (669 aa) |
| | BMF | Bcl2 modifying factor. (184 aa) |
| | BRCA1 | Uncharacterized protein. (1884 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (280 aa) |
| | CDC25A | Cell division cycle 25A. (491 aa) |
| | CDCA5 | Cell division cycle associated 5. (252 aa) |
| | SHC1 | SHC adaptor protein 1. (584 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | SERPINB5 | Serpin family B member 5; Belongs to the serpin family. (375 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | GLS2 | Glutaminase 2. (602 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | KIF23 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (974 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (802 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | EFNA3 | Ephrin A3; Belongs to the ephrin family. (240 aa) |
| | IRS2 | Insulin receptor substrate 2. (1279 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | MCL1 | Uncharacterized protein. (350 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1127 aa) |
| | PRKCG | Protein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa) |
| | PIM1 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (402 aa) |
| | NRAS | Uncharacterized protein. (189 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) |
| | EZR | Ezrin. (586 aa) |
| | DICER1 | Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1920 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa) |
| | VIM | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2301 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | E2F3 | E2F transcription factor 3. (335 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | EFNA2 | Ephrin A2; Belongs to the ephrin family. (181 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | PIK3R2 | Uncharacterized protein. (694 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | BMI1 | RING-type domain-containing protein. (326 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa) |
| | PLAU | Plasminogen activator, urokinase. (430 aa) |
| | ABCB1 | Multidrug resistance p-glycoprotein. (1283 aa) |
| | SLC45A3 | Solute carrier family 45 member 3. (553 aa) |
| | SIRT1 | Sirtuin 1. (743 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa) |
| | CYP24A1 | Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa) |
| | EFNA1 | Ephrin A1; Belongs to the ephrin family. (205 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1406 aa) |
| | NOTCH3 | Notch receptor 3. (2300 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | APC | APC regulator of WNT signaling pathway. (2861 aa) |
| | STMN1 | Stathmin; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity); Belongs to the stathmin family. (172 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (788 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | IRS1 | Insulin receptor substrate 1. (1241 aa) |
| | MMP16 | Matrix metallopeptidase 16. (607 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1353 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | ABCC1 | Multidrug resistance-associated protein 1; Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in [...] (1496 aa) |
| | HMOX1 | Uncharacterized protein. (288 aa) |
| | EP300 | E1A binding protein p300. (2414 aa) |
| | DNMT3B | DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (853 aa) |
| | ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa) |
| | EFNA5 | Ephrin A5; Belongs to the ephrin family. (228 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
| | NOTCH1 | Notch receptor 1. (2556 aa) |
