STRINGSTRING
TGFB1 TGFB1 PIK3R3 PIK3R3 MAP2K1 MAP2K1 PIK3CD PIK3CD HRAS HRAS GRB2 GRB2 CDKN1A CDKN1A ARNT2 ARNT2 MAPK1 MAPK1 ETS1 ETS1 TGFB2 TGFB2 PIK3CB PIK3CB SOS2 SOS2 BRAF BRAF TGFB3 TGFB3 ELOB ELOB PAK4 PAK4 MET MET PRCC PRCC ARAF ARAF PDGFB PDGFB SOS1 SOS1 AKT1 AKT1 SLC2A1 SLC2A1 HIF1A HIF1A CDC42 CDC42 PAK6 PAK6 AKT3 AKT3 BAD BAD GAB1 GAB1 CUL2 CUL2 TGFA TGFA PIK3CA PIK3CA PIK3R1 PIK3R1 FH FH MAPK3 MAPK3 NRAS NRAS EGLN3 EGLN3 PAK1 PAK1 AKT2 AKT2 CRKL CRKL KRAS KRAS EPAS1 EPAS1 RAP1A RAP1A CREBBP CREBBP PIK3R2 PIK3R2 HGF HGF FLCN FLCN RAF1 RAF1 ELOC ELOC EGLN2 EGLN2 PAK5 PAK5 RAP1B RAP1B PTPN11 PTPN11 EGLN1 EGLN1 RBX1 RBX1 PAK3 PAK3 ARNT ARNT MAP2K2 MAP2K2 EP300 EP300 PAK2 PAK2 CRK CRK TFE3 TFE3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor-binding protein 2. (217 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (717 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ELOBElongin B. (162 aa)
PAK4Non-specific serine/threonine protein kinase. (600 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
PRCCProline rich mitotic checkpoint control factor. (491 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
HIF1AUncharacterized protein. (831 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
BADBCL2 associated agonist of cell death. (167 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
CUL2Cullin 2; Belongs to the cullin family. (764 aa)
TGFATransforming growth factor alpha. (166 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FHFumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting [...] (510 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
NRASUncharacterized protein. (189 aa)
EGLN3Fe2OG dioxygenase domain-containing protein. (239 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
CREBBPCREB binding protein. (2442 aa)
PIK3R2Uncharacterized protein. (694 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
FLCNFolliculin. (579 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
RAP1BRas-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (418 aa)
RBX1RING-box protein 1. (108 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
EP300E1A binding protein p300. (2414 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.