STRINGSTRING
FOXO3 FOXO3 PIK3R3 PIK3R3 MAP2K1 MAP2K1 CCND1 CCND1 PIK3CD PIK3CD HRAS HRAS AXIN2 AXIN2 GRB2 GRB2 CDKN1A CDKN1A MAPK1 MAPK1 AXIN1 AXIN1 GSK3B GSK3B PIK3CB PIK3CB SOS2 SOS2 CTNNB1 CTNNB1 BRAF BRAF MLH1 MLH1 ENSMFAP00000011401 ENSMFAP00000011401 BAK1 BAK1 ARAF ARAF DDB2 DDB2 SOS1 SOS1 AKT1 AKT1 CDH1 CDH1 BAX BAX AKT3 AKT3 BAD BAD TCF7L1 TCF7L1 GADD45A GADD45A TCF7L2 TCF7L2 POLK POLK CASP9 CASP9 TCF7 TCF7 PIK3CA PIK3CA PIK3R1 PIK3R1 MAPK3 MAPK3 GADD45B GADD45B CTNNA3 CTNNA3 NRAS NRAS LEF1 LEF1 APC2 APC2 AKT2 AKT2 PTEN PTEN EGF EGF KRAS KRAS CTNNA2 CTNNA2 PIK3R2 PIK3R2 EGFR EGFR RAF1 RAF1 TP53 TP53 ERBB2 ERBB2 CTNNA1 CTNNA1 APC APC ELK1 ELK1 MYC MYC MAP2K2 MAP2K2 GADD45G GADD45G
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXO3Forkhead box O3. (672 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AXIN2Axin 2. (844 aa)
GRB2Growth factor receptor-binding protein 2. (217 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
AXIN1Axin 1. (867 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CTNNB1Catenin beta 1. (781 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
MLH1MutL homolog 1. (756 aa)
ENSMFAP00000011401ETS domain-containing protein. (426 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
BADBCL2 associated agonist of cell death. (167 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
TCF7L2Transcription factor 7 like 2. (542 aa)
POLKDNA polymerase kappa. (870 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
TCF7Transcription factor 7. (398 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
CTNNA3Catenin alpha 3. (895 aa)
NRASUncharacterized protein. (189 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CTNNA2Catenin alpha 2. (953 aa)
PIK3R2Uncharacterized protein. (694 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
ERBB2Receptor protein-tyrosine kinase. (1406 aa)
CTNNA1Catenin alpha 1. (906 aa)
APCAPC regulator of WNT signaling pathway. (2861 aa)
ELK1ETS domain-containing protein Elk-1. (428 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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