STRINGSTRING
IL18 IL18 TGFB1 TGFB1 IL23A IL23A IL12B IL12B HLA-DPA1 HLA-DPA1 NFKB1 NFKB1 STAT3 STAT3 TNF TNF IL17A IL17A LOC102140782 LOC102140782 IFNGR2 IFNGR2 SMAD3 SMAD3 TGFB2 TGFB2 IL5 IL5 HLA-DRB5 HLA-DRB5 IL21R IL21R RORC RORC DQB1 DQB1 TLR2 TLR2 NFATC1 NFATC1 TGFB3 TGFB3 IL21 IL21 TLR5 TLR5 IL13 IL13 HLA-DRA HLA-DRA IL18R1 IL18R1 IL12A IL12A IL4R IL4R RELA RELA IL2 IL2 IL1A IL1A IL18RAP IL18RAP IL1B IL1B RORA RORA IL2RG IL2RG IFNG IFNG IL12RB2 IL12RB2 IL17F IL17F SMAD2 SMAD2 IL12RB1 IL12RB1 TBX21 TBX21 GATA3 GATA3 STAT6 STAT6 STAT1 STAT1 IL4 IL4 IL10 IL10 HLA-DOB HLA-DOB IL23R IL23R IFNGR1 IFNGR1 LOC102140649 LOC102140649 IL22 IL22 NOD2 NOD2 STAT4 STAT4 HLA-DOA HLA-DOA TLR4 TLR4 IL6 IL6
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL23AInterleukin 23 p19 subunit. (189 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL17AInterleukin 17A. (155 aa)
LOC102140782Ig-like domain-containing protein. (325 aa)
IFNGR2Interferon gamma receptor 2. (336 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
HLA-DRB5Ig-like domain-containing protein. (286 aa)
IL21RInterleukin 21 receptor. (538 aa)
RORCRAR related orphan receptor C. (518 aa)
DQB1Ig-like domain-containing protein. (156 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
NFATC1Nuclear factor of activated T cells 1. (812 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
TLR5TIR domain-containing protein; Belongs to the Toll-like receptor family. (871 aa)
IL13Interleukin 13. (146 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IL4RInterleukin 4 receptor. (825 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (271 aa)
IL18RAPInterleukin 18 receptor accessory protein. (598 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
RORARAR related orphan receptor A. (555 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (863 aa)
IL17FInterleukin 17F. (163 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (662 aa)
TBX21T-box transcription factor 21. (535 aa)
GATA3GATA binding protein 3. (444 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
IL23RInterleukin 23 receptor. (629 aa)
IFNGR1Uncharacterized protein. (488 aa)
LOC102140649Ig-like domain-containing protein. (263 aa)
IL22Interleukin 22. (179 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1117 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (212 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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