STRINGSTRING
C8B C8B HLA-DPA1 HLA-DPA1 LOC102121517 LOC102121517 ENSMFAP00000001843 ENSMFAP00000001843 CTSG CTSG H2AZ2 H2AZ2 H2BC13 H2BC13 SNRPD3 SNRPD3 TNF TNF ACTN4 ACTN4 SSB SSB CD86 CD86 LOC102140782 LOC102140782 LOC102137233 LOC102137233 H2AZ1 H2AZ1 C5 C5 C8A C8A HLA-DRB5 HLA-DRB5 FCGR1A FCGR1A HIST1H3B HIST1H3B LOC102147067 LOC102147067 HIST1H2BO HIST1H2BO H2BC14 H2BC14 H2AC21 H2AC21 ENSMFAP00000010040 ENSMFAP00000010040 DQB1 DQB1 H2BC1 H2BC1 H2AC1 H2AC1 H2AC20 H2AC20 ENSMFAP00000010221 ENSMFAP00000010221 GRIN2B GRIN2B LOC102124047 LOC102124047 LOC102139130 LOC102139130 LOC102136612 LOC102136612 ENSMFAP00000010627 ENSMFAP00000010627 H2BC11 H2BC11 H2AX H2AX H2AC6 H2AC6 LOC102135686 LOC102135686 H2AC12 H2AC12 G8F3V0_MACFA G8F3V0_MACFA G7P2P1_MACFA G7P2P1_MACFA H2AC7 H2AC7 RO60 RO60 H2AJ H2AJ LOC102130997 LOC102130997 ENSMFAP00000011903 ENSMFAP00000011903 ENSMFAP00000012034 ENSMFAP00000012034 H3-4 H3-4 ENSMFAP00000012162 ENSMFAP00000012162 H2AW H2AW H2BU1 H2BU1 H2AC14 H2AC14 H2BC5 H2BC5 G8F2Z2_MACFA G8F2Z2_MACFA LOC102146894 LOC102146894 H2BC3 H2BC3 HIST2H2BE HIST2H2BE G8F5U3_MACFA G8F5U3_MACFA ENSMFAP00000014622 ENSMFAP00000014622 HLA-DRA HLA-DRA CD40 CD40 CD80 CD80 ENSMFAP00000020718 ENSMFAP00000020718 MACROH2A2 MACROH2A2 H3F3B H3F3B LOC102135038 LOC102135038 ENSMFAP00000022290 ENSMFAP00000022290 LOC102140945 LOC102140945 IFNG IFNG C3 C3 C1S C1S CD40LG CD40LG SNRPD1 SNRPD1 LOC102118733 LOC102118733 LOC102133669 LOC102133669 C6 C6 GRIN2A GRIN2A IL10 IL10 C7 C7 ENSMFAP00000033644 ENSMFAP00000033644 H2BC18 H2BC18 LOC102132156 LOC102132156 ACTN1 ACTN1 ENSMFAP00000034298 ENSMFAP00000034298 HLA-DOB HLA-DOB LOC102128954 LOC102128954 CD28 CD28 TRIM21 TRIM21 LOC102140649 LOC102140649 ENSMFAP00000035747 ENSMFAP00000035747 C1QA C1QA FCGR2B FCGR2B C1QB C1QB C1QC C1QC SNRPB SNRPB C1R C1R C8G C8G H2BW2 H2BW2 ELANE ELANE HLA-DOA HLA-DOA H2BC15 H2BC15 C9 C9 ENSMFAP00000045703 ENSMFAP00000045703
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C8BComplement C8 beta chain. (591 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
LOC102121517Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (103 aa)
ENSMFAP00000001843Ig-like domain-containing protein. (181 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (136 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ACTN4Actinin alpha 4. (931 aa)
SSBSjogren syndrome antigen B. (405 aa)
CD86CD86 molecule. (329 aa)
LOC102140782Ig-like domain-containing protein. (325 aa)
LOC102137233Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
C5Complement C5. (1676 aa)
C8AComplement C8 alpha chain. (584 aa)
HLA-DRB5Ig-like domain-containing protein. (286 aa)
FCGR1AUncharacterized protein. (375 aa)
HIST1H3BHistone H3; Belongs to the histone H3 family. (136 aa)
LOC102147067Histone H3; Belongs to the histone H3 family. (136 aa)
HIST1H2BOHistone H2B; Belongs to the histone H2B family. (126 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC21Histone H2A; Belongs to the histone H2A family. (130 aa)
ENSMFAP00000010040Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
DQB1Ig-like domain-containing protein. (156 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
H2AC1Histone H2A; Belongs to the histone H2A family. (131 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
ENSMFAP00000010221Histone H2A; Belongs to the histone H2A family. (130 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
LOC102124047Ig-like domain-containing protein. (217 aa)
LOC102139130Ig-like domain-containing protein. (118 aa)
LOC102136612Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
ENSMFAP00000010627Histone H3; Belongs to the histone H3 family. (136 aa)
H2BC11Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC102135686Ig-like domain-containing protein. (191 aa)
H2AC12Histone H2A; Belongs to the histone H2A family. (128 aa)
G8F3V0_MACFAHistone H2A; Belongs to the histone H2A family. (130 aa)
G7P2P1_MACFAHistone H2B; Belongs to the histone H2B family. (126 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
RO60TROVE domain-containing protein. (538 aa)
H2AJHistone H2A.J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (129 aa)
LOC102130997Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000011903Ig-like domain-containing protein. (133 aa)
ENSMFAP00000012034Histone H3; Belongs to the histone H3 family. (136 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000012162Histone H3; Belongs to the histone H3 family. (136 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC14Histone H2A; Belongs to the histone H2A family. (128 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
G8F2Z2_MACFAHistone H2B; Belongs to the histone H2B family. (126 aa)
LOC102146894Histone domain-containing protein. (136 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
G8F5U3_MACFAHistone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000014622Histone H2B; Belongs to the histone H2B family. (126 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
CD40CD40 molecule. (278 aa)
CD80CD80 molecule. (288 aa)
ENSMFAP00000020718Ig-like domain-containing protein. (193 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
LOC102135038Uncharacterized protein; Belongs to the peptidase S1 family. (664 aa)
ENSMFAP00000022290Histone domain-containing protein. (113 aa)
LOC102140945Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Binds IgG1 and IgG2 (By similarity). (277 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
C3Complement C3. (1663 aa)
C1SUncharacterized protein; Belongs to the peptidase S1 family. (688 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (119 aa)
LOC102118733Ig-like domain-containing protein. (192 aa)
LOC102133669Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
C6Complement C6. (934 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
C7Complement C7. (843 aa)
ENSMFAP00000033644Ig-like domain-containing protein. (192 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (134 aa)
LOC102132156Uncharacterized protein. (1744 aa)
ACTN1Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (914 aa)
ENSMFAP00000034298Histone H3; Belongs to the histone H3 family. (141 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
LOC102128954Ig-like domain-containing protein. (191 aa)
CD28IGv domain-containing protein. (234 aa)
TRIM21Tripartite motif containing 21. (475 aa)
LOC102140649Ig-like domain-containing protein. (263 aa)
ENSMFAP00000035747Ig-like domain-containing protein. (198 aa)
C1QAComplement C1q A chain. (245 aa)
FCGR2BUncharacterized protein. (317 aa)
C1QBComplement C1q B chain. (253 aa)
C1QCComplement C1q C chain. (245 aa)
SNRPBSmall nuclear ribonucleoprotein polypeptides B and B1. (330 aa)
C1RComplement C1r subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the peptidase S1 family. (698 aa)
C8GComplement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
H2BW2H2B histone family member M; Belongs to the histone H2B family. (153 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (264 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (165 aa)
C9Complement C9. (561 aa)
ENSMFAP00000045703Uncharacterized protein; Belongs to the peptidase S1 family. (687 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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