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TGFB1 TGFB1 CACNA1S CACNA1S MYL3 MYL3 DES DES ENSMFAP00000001843 ENSMFAP00000001843 ADCY6 ADCY6 SLC8A2 SLC8A2 TNF TNF CACNG1 CACNG1 SGCB SGCB ADCY8 ADCY8 RYR2 RYR2 ADCY2 ADCY2 CACNA2D2 CACNA2D2 TPM2 TPM2 CACNG5 CACNG5 CACNB1 CACNB1 ITGB6 ITGB6 TGFB2 TGFB2 SLC8A3 SLC8A3 TPM3-2 TPM3-2 TTN TTN ITGA9 ITGA9 MYH7 MYH7 ITGA4 ITGA4 ATP2A3 ATP2A3 ITGA11 ITGA11 CACNG7 CACNG7 ENSMFAP00000009633 ENSMFAP00000009633 PRKACA PRKACA LOC102124047 LOC102124047 LOC102139130 LOC102139130 LAMA1 LAMA1 AGT AGT ITGB5 ITGB5 LOC102135686 LOC102135686 CACNA2D4 CACNA2D4 ENSMFAP00000011903 ENSMFAP00000011903 TPM4-2 TPM4-2 TGFB3 TGFB3 SGCA SGCA ITGA7 ITGA7 PLN PLN PRKACG PRKACG ATP2A2 ATP2A2 IGF1 IGF1 TPM1 TPM1 ITGA2 ITGA2 CACNB2 CACNB2 ACTB ACTB SGCD SGCD CACNA2D3 CACNA2D3 ITGA8 ITGA8 CACNG8 CACNG8 CACNG6 CACNG6 ENSMFAP00000020718 ENSMFAP00000020718 CACNG4 CACNG4 ITGA10 ITGA10 ITGA3 ITGA3 GNAS GNAS PRKACB PRKACB DAG1 DAG1 TNNI3 TNNI3 ITGB7 ITGB7 CACNB4 CACNB4 CACNA2D1 CACNA2D1 EMD EMD DMD DMD LMNA LMNA CACNB3 CACNB3 LOC102118733 LOC102118733 MYL2 MYL2 CACNA1F CACNA1F SGCG SGCG ITGA5 ITGA5 ADCY5 ADCY5 ENSMFAP00000033644 ENSMFAP00000033644 LOC102128954 LOC102128954 ITGAV ITGAV MYBPC3 MYBPC3 ENSMFAP00000035747 ENSMFAP00000035747 CACNG2 CACNG2 TNNC1 TNNC1 ITGB1 ITGB1 ITGA1 ITGA1 ADCY7 ADCY7 ADCY1 ADCY1 ITGA6 ITGA6 CACNG3 CACNG3 ADCY3 ADCY3 ITGB3 ITGB3 CACNA1D CACNA1D LAMA2 LAMA2 ITGA2B ITGA2B ACTC1 ACTC1 ADCY4 ADCY4 ITGB8 ITGB8 MYH6 MYH6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
MYL3Myosin light chain 3. (225 aa)
DESDesmin; Belongs to the intermediate filament family. (470 aa)
ENSMFAP00000001843Ig-like domain-containing protein. (181 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (753 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
SGCBSarcoglycan beta. (307 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
RYR2Ryanodine receptor 2. (4943 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1134 aa)
TPM2Tropomyosin 2; Belongs to the tropomyosin family. (322 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (643 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
TPM3-2Uncharacterized protein. (237 aa)
TTNTitin. (32000 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1051 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1191 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
LOC102124047Ig-like domain-containing protein. (217 aa)
LOC102139130Ig-like domain-containing protein. (118 aa)
LAMA1Laminin subunit alpha 1. (3079 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (485 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
LOC102135686Ig-like domain-containing protein. (191 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1137 aa)
ENSMFAP00000011903Ig-like domain-containing protein. (133 aa)
TPM4-2Uncharacterized protein; Belongs to the tropomyosin family. (248 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SGCASarcoglycan alpha. (387 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
IGF1Insulin like growth factor 1. (159 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (379 aa)
SGCDSarcoglycan delta. (290 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1091 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (320 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (261 aa)
ENSMFAP00000020718Ig-like domain-containing protein. (193 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1352 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
GNASGNAS complex locus. (1023 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
DAG1Dystroglycan 1. (894 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
EMDEmerin. (257 aa)
DMDDystrophin. (3685 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (663 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
LOC102118733Ig-like domain-containing protein. (192 aa)
MYL2Myosin light chain 2. (166 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
SGCGSarcoglycan gamma. (291 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
ENSMFAP00000033644Ig-like domain-containing protein. (192 aa)
LOC102128954Ig-like domain-containing protein. (191 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
MYBPC3Myosin binding protein C, cardiac. (1274 aa)
ENSMFAP00000035747Ig-like domain-containing protein. (198 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
CACNG3Voltage-dependent calcium channel gamma-3 subunit; Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. (301 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (769 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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