STRINGSTRING
CAPN15 CAPN15 PPP1R1B PPP1R1B PTRHD1 PTRHD1 PNMT PNMT KCNE5 KCNE5 POMC POMC FCSK FCSK TAC1 TAC1 HTT HTT FOS FOS AGRP AGRP NPY NPY HRH3 HRH3 PRKCA PRKCA POU4F2 POU4F2 ZNFX1 ZNFX1 RIT2 RIT2 PVALB PVALB DLG4 DLG4 LOC708538 LOC708538 SOD1 SOD1 HRH1 HRH1 SHH SHH SLC6A3 SLC6A3 ISL1 ISL1 ACHE ACHE CNGA2 CNGA2 KCNK3 KCNK3 RHO RHO ATXN1 ATXN1 OMP OMP SNCA SNCA SMN1 SMN1 GRIA1 GRIA1 SNTG2 SNTG2 KCNK9 KCNK9 BDNF BDNF DCTN4 DCTN4 PARK7 PARK7 SAV1 SAV1 PINK1 PINK1 RBFOX3 RBFOX3 DCX DCX LOC100424620 LOC100424620 OR10K2 OR10K2 TRPA1 TRPA1 ADCY3 ADCY3 SLC18A3 SLC18A3 NGF NGF GFAP GFAP TRPM1 TRPM1 NUMB NUMB NR4A2 NR4A2 SLC1A6 SLC1A6 CDS1 CDS1 BCHE BCHE NOL4L NOL4L MCM8 MCM8 POU4F1 POU4F1 TRPV1 TRPV1 VSX2 VSX2 LGALS4 LGALS4 IGDCC3 IGDCC3 TLR3 TLR3 PRKN PRKN SLC17A6 SLC17A6 FUS FUS SLC27A3 SLC27A3 GRIN2B GRIN2B GDNF GDNF WNK1 WNK1 RBM23 RBM23 GRM6 GRM6 DBH DBH CNGA4 CNGA4 DACH2 DACH2 C15H9orf72 C15H9orf72 LRRK2 LRRK2 SCN10A SCN10A HTR1B HTR1B GAD1 GAD1 PARD3B PARD3B APP APP DRD2 DRD2 XXYLT1 XXYLT1 UNC119 UNC119 GAD2 GAD2 TBR1 TBR1 ENTPD5 ENTPD5 OXT OXT CHD1L CHD1L CALB2 CALB2 SMC3 SMC3 TPH2 TPH2 TARDBP TARDBP CALB1 CALB1 HCRT HCRT TPH1 TPH1 GJA10 GJA10 MID1 MID1 NEK11 NEK11 CHAT CHAT SUFU SUFU TRIM8 TRIM8 DZANK1 DZANK1 TH TH OPN4 OPN4 CACNA1A CACNA1A SLC6A4 SLC6A4 SLC32A1 SLC32A1 HDC HDC SNTG1 SNTG1 GRID2 GRID2 HTR1A HTR1A SST SST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAPN15Calpain 15; Belongs to the peptidase C2 family. (1154 aa)
PPP1R1BUncharacterized protein. (433 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
PNMTPhenylethanolamine N-methyltransferase. (282 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
POMCUncharacterized protein. (392 aa)
FCSKFucose kinase. (1084 aa)
TAC1Tachykinin precursor 1. (246 aa)
HTTHuntingtin. (3170 aa)
FOSV-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa)
AGRPAgouti related neuropeptide. (132 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. (169 aa)
HRH3Histamine receptor H3; Belongs to the G-protein coupled receptor 1 family. (445 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
POU4F2POU domain protein. (408 aa)
ZNFX1NFX1-type zinc finger-containing protein 1. (1918 aa)
RIT2Ras-like protein expressed in neurons. (217 aa)
PVALBParvalbumin; Belongs to the parvalbumin family. (178 aa)
DLG4Uncharacterized protein; Belongs to the MAGUK family. (972 aa)
LOC708538Tudor domain-containing protein. (275 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (161 aa)
HRH1Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (489 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (631 aa)
ISL1ISL LIM homeobox 1. (413 aa)
ACHEUncharacterized protein; Belongs to the type-B carboxylesterase/lipase family. (848 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (664 aa)
KCNK3Potassium channel subfamily K member. (394 aa)
RHORhodopsin. (348 aa)
ATXN1Ataxin 1. (817 aa)
OMPOlfactory marker protein. (227 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (146 aa)
SMN1Tudor domain-containing protein. (297 aa)
GRIA1Uncharacterized protein. (916 aa)
SNTG2Syntrophin gamma 2. (544 aa)
KCNK9Potassium two pore domain channel subfamily K member 9; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (501 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
DCTN4Uncharacterized protein. (467 aa)
PARK7Protein DJ-1. (189 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (581 aa)
RBFOX3RNA binding protein fox-1 homolog 3; RNA-binding protein that regulates alternative splicing events. (359 aa)
DCXDoublecortin. (387 aa)
LOC100424620SMN domain-containing protein. (87 aa)
OR10K2Olfactory receptor family 10 subfamily K member 2. (312 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1144 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
SLC18A3Solute carrier family 18 member A3. (532 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (462 aa)
TRPM1Transient receptor potential cation channel subfamily M member 1. (1642 aa)
NUMBNUMB endocytic adaptor protein. (711 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
SLC1A6Amino acid transporter. (564 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
BCHECholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). (602 aa)
NOL4LUncharacterized protein. (680 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (1009 aa)
POU4F1POU domain protein. (423 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (839 aa)
VSX2Visual system homeobox 2. (361 aa)
LGALS4Galectin. (323 aa)
IGDCC3Immunoglobulin superfamily DCC subclass member 3. (813 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
SLC17A6Solute carrier family 17 member 6. (582 aa)
FUSTripartite motif containing 72. (534 aa)
SLC27A3Solute carrier family 27 member 3. (810 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
GDNFGlial cell derived neurotrophic factor. (342 aa)
WNK1WNK lysine deficient protein kinase 1. (2844 aa)
RBM23Uncharacterized protein. (442 aa)
GRM6Glutamate metabotropic receptor 6. (877 aa)
DBHDopamine beta-hydroxylase. (620 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (575 aa)
DACH2Dachshund family transcription factor 2. (599 aa)
C15H9orf72Uncharacterized protein. (481 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1956 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
GAD1Glutamate decarboxylase 1 isoform GAD67. (594 aa)
PARD3BPar-3 family cell polarity regulator beta. (1204 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
XXYLT1Uncharacterized protein. (393 aa)
UNC119Protein unc-119 homolog A isoform a. (240 aa)
GAD2Glutamate decarboxylase 2. (608 aa)
TBR1T-box brain transcription factor 1. (682 aa)
ENTPD5Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (849 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
CHD1LChromodomain-helicase-DNA-binding protein 1-like. (900 aa)
CALB2Uncharacterized protein. (272 aa)
SMC3Structural maintenance of chromosomes protein. (1196 aa)
TPH2Tryptophan 5-hydroxylase 2. (490 aa)
TARDBPTAR DNA-binding protein 43. (414 aa)
CALB1Calbindin 1. (261 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
GJA10Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (543 aa)
MID1Midline 1. (667 aa)
NEK11Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (955 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (737 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (500 aa)
TRIM8Putative E3 ubiquitin-protein ligase TRIM8. (551 aa)
DZANK1Double zinc ribbon and ankyrin repeat domains 1. (777 aa)
THTyrosine hydroxylase. (501 aa)
OPN4Opsin 4. (489 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2411 aa)
SLC6A4Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. (630 aa)
SLC32A1Vesicular inhibitory amino acid transporter. (525 aa)
HDCHistidine decarboxylase. (662 aa)
SNTG1Syntrophin gamma 1. (534 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
HTR1A5-hydroxytryptamine receptor 1A. (421 aa)
SSTSomatostatin preproprotein. (116 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (14%) [HD]