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PLP1 PLP1 GFAP GFAP ACTG1 ACTG1 MBP MBP MOG MOG STXBP1 STXBP1 GAD1 GAD1 SLC17A7 SLC17A7 APP APP LOC705671 LOC705671 NRGN NRGN PCDH9 PCDH9 MAPT MAPT SST SST CKB CKB S100B S100B SYN1 SYN1 CLU CLU CAMK2A CAMK2A PVALB PVALB DLG4 DLG4 SYP SYP PRNP PRNP ENO2 ENO2 RAB3D RAB3D ALDOC ALDOC ATP1B2 ATP1B2 TPT1 TPT1 APLP1 APLP1 ACTB ACTB RBFOX3 RBFOX3 ATP1A3 ATP1A3 UBB UBB APOE APOE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLP1Uncharacterized protein. (281 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (462 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
MBPMyelin basic protein. (437 aa)
MOGIg-like domain-containing protein. (294 aa)
STXBP1Syntaxin-binding protein 1 isoform a; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
GAD1Glutamate decarboxylase 1 isoform GAD67. (594 aa)
SLC17A7Solute carrier family 17 member 7. (560 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa)
LOC705671Uncharacterized protein. (398 aa)
NRGNNeurogranin. (78 aa)
PCDH9Protocadherin-9 isoform 1. (1237 aa)
MAPTMicrotubule-associated protein. (823 aa)
SSTSomatostatin preproprotein. (116 aa)
CKBUncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (458 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
SYN1Synapsin-1 isoform Ia. (705 aa)
CLUClusterin; Belongs to the clusterin family. (489 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha. (622 aa)
PVALBParvalbumin; Belongs to the parvalbumin family. (178 aa)
DLG4Uncharacterized protein; Belongs to the MAGUK family. (972 aa)
SYPSynaptophysin. (401 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa)
ENO2Gamma-enolase. (434 aa)
RAB3DRas-related protein Rab-3A. (220 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (299 aa)
TPT1TCTP domain-containing protein; Belongs to the TCTP family. (196 aa)
APLP1Amyloid beta precursor like protein 1. (428 aa)
ACTBUncharacterized protein. (421 aa)
RBFOX3RNA binding protein fox-1 homolog 3; RNA-binding protein that regulates alternative splicing events. (359 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1031 aa)
UBBUncharacterized protein. (229 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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