node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACHE | BDNF | ENSMMUP00000063657 | ENSMMUP00000059263 | Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family. | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.551 |
ACHE | CHAT | ENSMMUP00000063657 | ENSMMUP00000006239 | Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family. | Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. | 0.547 |
ACHE | NGF | ENSMMUP00000063657 | ENSMMUP00000046298 | Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family. | Nerve growth factor; Belongs to the NGF-beta family. | 0.535 |
ACHE | PVALB | ENSMMUP00000063657 | ENSMMUP00000068520 | Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family. | Parvalbumin; Belongs to the parvalbumin family. | 0.749 |
ACHE | SNCA | ENSMMUP00000063657 | ENSMMUP00000061274 | Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.443 |
BDNF | ACHE | ENSMMUP00000059263 | ENSMMUP00000063657 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family. | 0.551 |
BDNF | CRH | ENSMMUP00000059263 | ENSMMUP00000028431 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Corticotropin releasing hormone. | 0.708 |
BDNF | FOS | ENSMMUP00000059263 | ENSMMUP00000071593 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | V-fos FBJ murine osteosarcoma viral oncogene-like protein. | 0.788 |
BDNF | HCRT | ENSMMUP00000059263 | ENSMMUP00000008448 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. | 0.503 |
BDNF | NGF | ENSMMUP00000059263 | ENSMMUP00000046298 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Nerve growth factor; Belongs to the NGF-beta family. | 0.910 |
BDNF | PVALB | ENSMMUP00000059263 | ENSMMUP00000068520 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Parvalbumin; Belongs to the parvalbumin family. | 0.855 |
BDNF | SNCA | ENSMMUP00000059263 | ENSMMUP00000061274 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.754 |
CHAT | ACHE | ENSMMUP00000006239 | ENSMMUP00000063657 | Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. | Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family. | 0.547 |
CRH | BDNF | ENSMMUP00000028431 | ENSMMUP00000059263 | Corticotropin releasing hormone. | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.708 |
CRH | FOS | ENSMMUP00000028431 | ENSMMUP00000071593 | Corticotropin releasing hormone. | V-fos FBJ murine osteosarcoma viral oncogene-like protein. | 0.738 |
CRH | HCRT | ENSMMUP00000028431 | ENSMMUP00000008448 | Corticotropin releasing hormone. | Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. | 0.745 |
FOS | BDNF | ENSMMUP00000071593 | ENSMMUP00000059263 | V-fos FBJ murine osteosarcoma viral oncogene-like protein. | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.788 |
FOS | CRH | ENSMMUP00000071593 | ENSMMUP00000028431 | V-fos FBJ murine osteosarcoma viral oncogene-like protein. | Corticotropin releasing hormone. | 0.738 |
FOS | HCRT | ENSMMUP00000071593 | ENSMMUP00000008448 | V-fos FBJ murine osteosarcoma viral oncogene-like protein. | Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. | 0.806 |
FOS | NGF | ENSMMUP00000071593 | ENSMMUP00000046298 | V-fos FBJ murine osteosarcoma viral oncogene-like protein. | Nerve growth factor; Belongs to the NGF-beta family. | 0.552 |