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| | LOC709234 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa) |
| | CYP21A2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa) |
| | CYP11B2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa) |
| | NR1I2 | Nuclear receptor subfamily 1 group I member 2; Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By s [...] (473 aa) |
| | LOC100424965 | Uncharacterized protein; Belongs to the cytochrome P450 family. (497 aa) |
| | CYP3A4 | Uncharacterized protein. (535 aa) |
| | HSD17B8 | Estradiol 17-beta-dehydrogenase 8. (261 aa) |
| | ESD | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (293 aa) |
| | DHRS3 | Short-chain dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa) |
| | AOX2 | Uncharacterized protein. (1354 aa) |
| | CYP2A24 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | ALDH1A3 | Aldehyde dehydrogenase family 1 member A3; Belongs to the aldehyde dehydrogenase family. (512 aa) |
| | DHRS4L1 | Uncharacterized protein. (146 aa) |
| | DHRS4 | Uncharacterized protein. (278 aa) |
| | HSD11B2 | Hydroxysteroid 11-beta dehydrogenase 2. (405 aa) |
| | DHRS1 | Dehydrogenase/reductase SDR family member 1. (313 aa) |
| | ADH4 | Alcohol dehydrogenase 4 (class II), pi polypeptide. (398 aa) |
| | RDH8 | Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa) |
| | HSD3B1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; Belongs to the 3-beta-HSD family. (373 aa) |
| | SRD5A1 | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (263 aa) |
| | CYP1B1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (542 aa) |
| | FMO4 | Dimethylaniline monooxygenase [N-oxide-forming]. (558 aa) |
| | RLBP1 | Retinaldehyde binding protein 1. (317 aa) |
| | BCO2 | Beta-carotene oxygenase 2. (567 aa) |
| | CBR4 | Carbonyl reductase family member 4. (237 aa) |
| | ADH6 | PKS_ER domain-containing protein. (374 aa) |
| | LOC709132 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa) |
| | CYP2D42 | Cytochrome P450 CYP2D42; Belongs to the cytochrome P450 family. (497 aa) |
| | CYP2B6 | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. (491 aa) |
| | ALDH1A2 | Retinal dehydrogenase 2 isoform 1; Belongs to the aldehyde dehydrogenase family. (518 aa) |
| | CYP2C9 | Uncharacterized protein; Belongs to the cytochrome P450 family. (650 aa) |
| | LOC709461 | Uncharacterized protein; Belongs to the cytochrome P450 family. (519 aa) |
| | AKR1A1 | Alcohol dehydrogenase [NADP+]. (325 aa) |
| | UGT1A1 | UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. (570 aa) |
| | CYP1A2 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (515 aa) |
| | SULT2B1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (363 aa) |
| | RDH13 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa) |
| | CYP1A1 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (512 aa) |
| | ALDH3B2 | Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family. (385 aa) |
| | CYP2S1 | Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (504 aa) |
| | CYP11B1 | Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa) |
| | SDR16C5 | Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa) |
| | LOC708065 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (521 aa) |
| | ADH1A | Alcohol dehydrogenase 1A. (374 aa) |
| | CYP26C1 | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa) |
| | LOC704750 | Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (512 aa) |
| | DHRS9 | Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (378 aa) |
| | HSD17B3 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa) |
| | ADH5 | S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (401 aa) |
| | ALDH3B1 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (533 aa) |
| | CYP8B1 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa) |
| | LOC709535 | Cytochrome P450 4X1; Belongs to the cytochrome P450 family. (509 aa) |
| | HSD11B1L | Hydroxysteroid 11-beta dehydrogenase 1 like. (300 aa) |
| | AKR1C1 | Aldo_ket_red domain-containing protein. (323 aa) |
| | DHRS7B | Dehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (370 aa) |
| | CYP2E1 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (530 aa) |
| | HSD17B2 | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (387 aa) |
| | RDH10 | Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa) |
| | ALDH3A1 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (467 aa) |
| | AOX1 | Aldehyde oxidase 1. (1338 aa) |
| | CYP19A1 | Cytochrome P450 19A1; Belongs to the cytochrome P450 family. (503 aa) |
| | LOC114674219 | Uncharacterized protein; Belongs to the cytochrome P450 family. (492 aa) |
| | STS | Steroid sulfatase. (590 aa) |
| | UGT2A3 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa) |
| | BCO1 | Beta,beta-carotene 15,15'-monooxygenase. (547 aa) |
| | AKR1D1 | Aldo-keto reductase family 1 member D1. (326 aa) |
| | UGT2B7 | UDP-glucuronosyltransferase 2B33; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid. (529 aa) |
| | AKR1C8P | Aldo-keto reductase family 1 member C8, pseudogene. (332 aa) |
| | ADH7 | Alcohol dehydrogenase 1B (class I), beta polypeptide. (375 aa) |
| | ISX | Intestine specific homeobox. (245 aa) |
| | RETSAT | Retinol saturase. (623 aa) |
| | SULT2A1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa) |
| | PNPLA4 | PNPLA domain-containing protein. (277 aa) |
| | ALDH1A1 | Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (527 aa) |
| | SRD5A2 | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa) |
| | RDH5 | Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa) |
| | RPE65 | Retinoid isomerohydrolase RPE65. (533 aa) |
| | AWAT2 | Acyl-CoA wax alcohol acyltransferase 2. (333 aa) |
| | LRAT | LRAT domain-containing protein. (230 aa) |
| | HSD17B6 | 17-beta-hydroxysteroid dehydrogenase type 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa) |
| | LOC722496 | Aldo_ket_red domain-containing protein. (322 aa) |
| | CYP27C1 | Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa) |
| | RDH11 | Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa) |
| | HSD17B1 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (396 aa) |
| | RDH12 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa) |
| | RDH16 | Retinol dehydrogenase 16; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa) |
| | SULT1E1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (294 aa) |
| | HSD3B2 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo- Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controllin [...] (422 aa) |
| | CYP26A1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (555 aa) |
| | CYP2A23 | Uncharacterized protein; Belongs to the cytochrome P450 family. (493 aa) |
| | HSD11B1 | Uncharacterized protein. (292 aa) |
| | DHRS7 | Dehydrogenase/reductase SDR family member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa) |
