(53 nodes) Ribonucleoside monophosphate biosynthetic process, and 5-nucleotidase activity network (Macaca mulatta)

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Your Input:
	ADSS2	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
	LOC698764	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (513 aa)
	LOC716161	Uncharacterized protein. (886 aa)
	AMPD1	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (747 aa)
	ADA2	Adenosine deaminase 2. (509 aa)
	NT5C2	Cytosolic purine 5'-nucleotidase. (569 aa)
	NT5E	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
	IMPDH2	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (538 aa)
	AMPD2	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (879 aa)
	PAICS	AIRC domain-containing protein. (431 aa)
	DTYMK	Deoxythymidylate kinase. (212 aa)
	UCK1	Uridine-cytidine kinase 1. (291 aa)
	UPP2	Uridine phosphorylase 2. (317 aa)
	GMPR2	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (366 aa)
	NT5C3B	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (354 aa)
	PFAS	Phosphoribosylformylglycinamidine synthase. (1335 aa)
	RDH14	Uncharacterized protein. (708 aa)
	AMPD3	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (776 aa)
	PPAT	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa)
	TPMT	Thiopurine S-methyltransferase. (245 aa)
	ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (620 aa)
	NUDT12	Peroxisomal NADH pyrophosphatase NUDT12. (462 aa)
	NUDT9	ADP-ribose pyrophosphatase, mitochondrial isoform a. (350 aa)
	UPRT	Uracil phosphoribosyltransferase-like protein. (309 aa)
	TK1	Thymidine kinase. (269 aa)
	ADK	Adenosine kinase. (364 aa)
	NT5C	5'(3')-deoxyribonucleotidase, cytosolic type. (201 aa)
	DCK	Deoxycytidine kinase. (371 aa)
	NT5C3A	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (406 aa)
	ADA	Adenosine deaminase. (390 aa)
	GUK1	Guanylate kinase 1. (363 aa)
	PRPS2	Phosphoribosyl pyrophosphate synthetase 2. (444 aa)
	ADSL	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (484 aa)
	CMPK2	Cytidine/uridine monophosphate kinase 2. (453 aa)
	GMPS	Uncharacterized protein. (712 aa)
	CEP44	Centrosomal protein 44. (399 aa)
	NUDT16	Uncharacterized protein. (198 aa)
	GART	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1019 aa)
	DCTD	CMP/dCMP-type deaminase domain-containing protein. (191 aa)
	TK2	Thymidine kinase 2. (268 aa)
	IMPDH1	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (599 aa)
	HPRT1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
	NT5M	5',3'-nucleotidase, mitochondrial. (243 aa)
	ADSS1	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (562 aa)
	UPP1	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (336 aa)
	DCTPP1	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (170 aa)
	ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa)
	PRPS1L1	Phosphoribosyl pyrophosphate synthetase 1 like 1. (318 aa)
	NT5C1A	5'-nucleotidase, cytosolic IA. (368 aa)
	GMPR	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (182 aa)
	UCK2	Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
	PRPS1	Ribose-phosphate pyrophosphokinase 1 isoform 1. (318 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	ADA2	ENSMMUP00000037978	ENSMMUP00000003402	Adenosine deaminase.	Adenosine deaminase 2.	0.941
ADA	ADK	ENSMMUP00000037978	ENSMMUP00000029270	Adenosine deaminase.	Adenosine kinase.	0.985
ADA	ADSL	ENSMMUP00000037978	ENSMMUP00000043706	Adenosine deaminase.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.620
ADA	ADSS1	ENSMMUP00000037978	ENSMMUP00000062985	Adenosine deaminase.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.548
ADA	ADSS2	ENSMMUP00000037978	ENSMMUP00000000021	Adenosine deaminase.	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.490
ADA	AMPD1	ENSMMUP00000037978	ENSMMUP00000002646	Adenosine deaminase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.412
ADA	AMPD2	ENSMMUP00000037978	ENSMMUP00000007673	Adenosine deaminase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.419
ADA	AMPD3	ENSMMUP00000037978	ENSMMUP00000020742	Adenosine deaminase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.417
ADA	CDA	ENSMMUP00000037978	ENSMMUP00000078336	Adenosine deaminase.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.685
ADA	DCK	ENSMMUP00000037978	ENSMMUP00000035110	Adenosine deaminase.	Deoxycytidine kinase.	0.939
ADA	GART	ENSMMUP00000037978	ENSMMUP00000054383	Adenosine deaminase.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.741
ADA	GMPR	ENSMMUP00000037978	ENSMMUP00000077971	Adenosine deaminase.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.532
ADA	GMPR2	ENSMMUP00000037978	ENSMMUP00000016356	Adenosine deaminase.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.540
ADA	GMPS	ENSMMUP00000037978	ENSMMUP00000045470	Adenosine deaminase.	Uncharacterized protein.	0.695
ADA	HPRT1	ENSMMUP00000037978	ENSMMUP00000060630	Adenosine deaminase.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.497
ADA	IMPDH1	ENSMMUP00000037978	ENSMMUP00000060554	Adenosine deaminase.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.547
ADA	IMPDH2	ENSMMUP00000037978	ENSMMUP00000007479	Adenosine deaminase.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.549
ADA	LOC698764	ENSMMUP00000037978	ENSMMUP00000000964	Adenosine deaminase.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.552
ADA	NT5C	ENSMMUP00000037978	ENSMMUP00000034100	Adenosine deaminase.	5'(3')-deoxyribonucleotidase, cytosolic type.	0.934
ADA	NT5C1A	ENSMMUP00000037978	ENSMMUP00000073121	Adenosine deaminase.	5'-nucleotidase, cytosolic IA.	0.901