STRINGSTRING
PIK3R2 PIK3R2 PIK3CA PIK3CA PLCG2 PLCG2 PIK3R5 PIK3R5 SHC1 SHC1 PTPN1 PTPN1 PIK3CB PIK3CB BLNK BLNK SH2B2 SH2B2 ITK ITK PIK3R1 PIK3R1 SH3GLB2 SH3GLB2 GRB14 GRB14 VAV2 VAV2 TEC TEC IRS4 IRS4 IRS2 IRS2 RRAS RRAS PIK3R6 PIK3R6 BTK BTK IRS1 IRS1 GRB2 GRB2 INSR INSR EGFR EGFR SOS2 SOS2 SH3GL1 SH3GL1 SHC3 SHC3 GRAP GRAP PTPN11 PTPN11 SHC4 SHC4 RAC2 RAC2 PLCG1 PLCG1 LCP2 LCP2 VAV1 VAV1 CBL CBL GAB2 GAB2 LAT LAT PIK3R3 PIK3R3 PIK3AP1 PIK3AP1 INSRR INSRR FGR FGR PIK3CG PIK3CG SOS1 SOS1 GRAP2 GRAP2 PIK3CD PIK3CD CBLB CBLB CBLC CBLC VAV3 VAV3 SH3GL2 SH3GL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (884 aa)
SHC1SHC-transforming protein 1 isoform 3. (584 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
BLNKB cell linker. (559 aa)
SH2B2SH2B adaptor protein 2. (680 aa)
ITKTyrosine-protein kinase. (620 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SH3GLB2SH3 domain containing GRB2 like, endophilin B2. (415 aa)
GRB14Growth factor receptor bound protein 14. (540 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform 1. (878 aa)
TECTyrosine-protein kinase. (685 aa)
IRS4Insulin receptor substrate 4. (1178 aa)
IRS2Insulin receptor substrate 2. (1394 aa)
RRASRas-related protein R-Ras. (218 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
BTKTyrosine-protein kinase. (659 aa)
IRS1Insulin receptor substrate 1. (1253 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
INSRInsulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...] (1279 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa)
SOS2Uncharacterized protein. (1332 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (440 aa)
SHC3Uncharacterized protein. (596 aa)
GRAPUncharacterized protein. (226 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SHC4Src-like proteiny 2 domain-containing-transforming protein C4. (630 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
VAV1Vav guanine nucleotide exchange factor 1. (928 aa)
CBLE3 ubiquitin-protein ligase CBL. (907 aa)
GAB2GRB2 associated binding protein 2. (677 aa)
LATUncharacterized protein. (305 aa)
PIK3R3Uncharacterized protein. (507 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
FGRTyrosine-protein kinase. (529 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1102 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
GRAP2GRB2 related adaptor protein 2. (348 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CBLBCbl proto-oncogene B. (982 aa)
CBLCCbl proto-oncogene C. (474 aa)
VAV3Vav guanine nucleotide exchange factor 3. (1128 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (383 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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