(13 nodes) Notch ligand, N-terminal domain, and Positive regulation of transcription of Notch receptor target network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RBPJL	Recombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
	NOTCH3	Notch receptor 3. (2321 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (1151 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	DLL3	Delta like canonical Notch ligand 3. (618 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	MAML3	Mastermind like transcriptional coactivator 3. (1133 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
	RBPJ	Uncharacterized protein. (500 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (1014 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1290 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	DLL3	ENSMMUP00000027839	ENSMMUP00000025101	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta like canonical Notch ligand 3.	0.919
DLL1	DLL4	ENSMMUP00000027839	ENSMMUP00000066068	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.943
DLL1	JAG1	ENSMMUP00000027839	ENSMMUP00000023809	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.583
DLL1	JAG2	ENSMMUP00000027839	ENSMMUP00000075280	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.455
DLL1	MAML1	ENSMMUP00000027839	ENSMMUP00000059707	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.708
DLL1	MAML2	ENSMMUP00000027839	ENSMMUP00000019434	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.715
DLL1	MAML3	ENSMMUP00000027839	ENSMMUP00000028971	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 3.	0.666
DLL1	NOTCH1	ENSMMUP00000027839	ENSMMUP00000022401	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.995
DLL1	NOTCH2	ENSMMUP00000027839	ENSMMUP00000046517	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein.	0.984
DLL1	NOTCH3	ENSMMUP00000027839	ENSMMUP00000017928	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.988
DLL1	RBPJ	ENSMMUP00000027839	ENSMMUP00000055029	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.850
DLL1	RBPJL	ENSMMUP00000027839	ENSMMUP00000004541	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region like.	0.562
DLL3	DLL1	ENSMMUP00000025101	ENSMMUP00000027839	Delta like canonical Notch ligand 3.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.919
DLL3	DLL4	ENSMMUP00000025101	ENSMMUP00000066068	Delta like canonical Notch ligand 3.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.916
DLL3	MAML1	ENSMMUP00000025101	ENSMMUP00000059707	Delta like canonical Notch ligand 3.	Mastermind like transcriptional coactivator 1.	0.653
DLL3	MAML2	ENSMMUP00000025101	ENSMMUP00000019434	Delta like canonical Notch ligand 3.	Mastermind like transcriptional coactivator 2.	0.655
DLL3	MAML3	ENSMMUP00000025101	ENSMMUP00000028971	Delta like canonical Notch ligand 3.	Mastermind like transcriptional coactivator 3.	0.654
DLL3	NOTCH1	ENSMMUP00000025101	ENSMMUP00000022401	Delta like canonical Notch ligand 3.	Notch receptor 1.	0.991
DLL3	NOTCH2	ENSMMUP00000025101	ENSMMUP00000046517	Delta like canonical Notch ligand 3.	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein.	0.966
DLL3	NOTCH3	ENSMMUP00000025101	ENSMMUP00000017928	Delta like canonical Notch ligand 3.	Notch receptor 3.	0.966