(39 nodes) Mixed, incl. Peptidase C1A, and Interferon-induced transmembrane protein network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC114677048	Serine protease 2; Belongs to the peptidase S1 family. (246 aa)
	TMPRSS11A	Transmembrane protease serine; Belongs to the peptidase S1 family. (421 aa)
	LAMP2	Lysosome-associated membrane glycoprotein 2 isoform B. (410 aa)
	LOC713135	Cystatin domain-containing protein. (147 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
	CD163	CD163 molecule. (1155 aa)
	LAMP1	Lysosomal associated membrane protein 1. (733 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (354 aa)
	F6ZD94_MACMU	Uncharacterized protein. (128 aa)
	F6ZD87_MACMU	Uncharacterized protein. (112 aa)
	CD68	CD68 molecule. (354 aa)
	TYRO3	Tyrosine-protein kinase receptor TYRO3. (890 aa)
	CTSZ	Cathepsin Z; Belongs to the peptidase C1 family. (303 aa)
	GP2	Glycoprotein 2. (534 aa)
	LOC703055	Cystatin domain-containing protein. (211 aa)
	LOC719235	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (422 aa)
	CTSC	Dipeptidyl peptidase 1 isoform a preproprotein; Belongs to the peptidase C1 family. (463 aa)
	CD209	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (444 aa)
	CTSV	Uncharacterized protein; Belongs to the peptidase C1 family. (355 aa)
	CTSL	Cathepsin L; Belongs to the peptidase C1 family. (333 aa)
	AXL	AXL receptor tyrosine kinase. (894 aa)
	LGMN	Legumain preproprotein. (433 aa)
	SERPINB13	Serpin family B member 13; Belongs to the serpin family. (400 aa)
	TMPRSS4	Transmembrane serine protease 4; Belongs to the peptidase S1 family. (437 aa)
	LOC106994543	SERPIN domain-containing protein; Belongs to the serpin family. (390 aa)
	ENSMMUP00000054262	Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
	ENSMMUP00000059753	Uncharacterized protein. (111 aa)
	LOC703291	Cystatin domain-containing protein. (116 aa)
	LOC697687	Uncharacterized protein. (250 aa)
	EEA1	Early endosome antigen 1. (1453 aa)
	CTSF	Cathepsin F; Belongs to the peptidase C1 family. (470 aa)
	LOC720763	Uncharacterized protein. (96 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (583 aa)
	CTSB	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (453 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (529 aa)
	NAPSA	Napsin A aspartic peptidase; Belongs to the peptidase A1 family. (420 aa)
	LOC712306	Cystatin domain-containing protein. (167 aa)
	CST6	Cystatin E/M; Belongs to the cystatin family. (157 aa)
	GAS6	Growth arrest specific 6. (684 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXL	CD209	ENSMMUP00000042442	ENSMMUP00000029559	AXL receptor tyrosine kinase.	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	0.889
AXL	CD68	ENSMMUP00000042442	ENSMMUP00000017747	AXL receptor tyrosine kinase.	CD68 molecule.	0.530
AXL	FURIN	ENSMMUP00000042442	ENSMMUP00000006194	AXL receptor tyrosine kinase.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.489
AXL	GAS6	ENSMMUP00000042442	ENSMMUP00000079729	AXL receptor tyrosine kinase.	Growth arrest specific 6.	0.999
AXL	GP2	ENSMMUP00000042442	ENSMMUP00000021555	AXL receptor tyrosine kinase.	Glycoprotein 2.	0.620
AXL	TYRO3	ENSMMUP00000042442	ENSMMUP00000018152	AXL receptor tyrosine kinase.	Tyrosine-protein kinase receptor TYRO3.	0.440
CD163	CD209	ENSMMUP00000006821	ENSMMUP00000029559	CD163 molecule.	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	0.664
CD163	CD68	ENSMMUP00000006821	ENSMMUP00000017747	CD163 molecule.	CD68 molecule.	0.882
CD163	GP2	ENSMMUP00000006821	ENSMMUP00000021555	CD163 molecule.	Glycoprotein 2.	0.916
CD209	AXL	ENSMMUP00000029559	ENSMMUP00000042442	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	AXL receptor tyrosine kinase.	0.889
CD209	CD163	ENSMMUP00000029559	ENSMMUP00000006821	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	CD163 molecule.	0.664
CD209	CD68	ENSMMUP00000029559	ENSMMUP00000017747	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	CD68 molecule.	0.627
CD209	CTSB	ENSMMUP00000029559	ENSMMUP00000067393	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.506
CD209	CTSL	ENSMMUP00000029559	ENSMMUP00000038922	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	Cathepsin L; Belongs to the peptidase C1 family.	0.488
CD209	CTSS	ENSMMUP00000029559	ENSMMUP00000013979	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	Cathepsin S; Belongs to the peptidase C1 family.	0.447
CD209	FURIN	ENSMMUP00000029559	ENSMMUP00000006194	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.636
CD209	GAS6	ENSMMUP00000029559	ENSMMUP00000079729	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	Growth arrest specific 6.	0.521
CD209	GP2	ENSMMUP00000029559	ENSMMUP00000021555	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	Glycoprotein 2.	0.530
CD209	TMPRSS11A	ENSMMUP00000029559	ENSMMUP00000000743	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	Transmembrane protease serine; Belongs to the peptidase S1 family.	0.435
CD209	TMPRSS2	ENSMMUP00000029559	ENSMMUP00000068248	CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.475