STRINGSTRING
PTGER2 PTGER2 PRSS2 PRSS2 OR8S1 OR8S1 LPAR2 LPAR2 GNG13 GNG13 GNAZ GNAZ ADRB2 ADRB2 GNA11 GNA11 TAS1R2 TAS1R2 GPRC6A GPRC6A ADORA3 ADORA3 GNB4 GNB4 PLCB1 PLCB1 DRD1 DRD1 GNB3 GNB3 PTGER1 PTGER1 GNAI3 GNAI3 TAS2R40 TAS2R40 PDCL PDCL LPAR1 LPAR1 KCNJ3 KCNJ3 RGS3 RGS3 GRM5 GRM5 LOC694289 LOC694289 AKAP13 AKAP13 ATP2B3 ATP2B3 HTR2B HTR2B PLCB3 PLCB3 CYSLTR1 CYSLTR1 CHRM5 CHRM5 RGS9 RGS9 HTR1B HTR1B PTGER4 PTGER4 GNA13 GNA13 GNA14 GNA14 CHRM1 CHRM1 PTGER3 PTGER3 GNB5 GNB5 MTNR1A MTNR1A TAS1R1 TAS1R1 GNAO1 GNAO1 GNAI2 GNAI2 PLEKHG5 PLEKHG5 CHRM3 CHRM3 GNG5 GNG5 TAS2R4 TAS2R4 DRD3 DRD3 F2RL2 F2RL2 GNAI1 GNAI1 ADRB3 ADRB3 KCNJ16 KCNJ16 GABBR1 GABBR1 OR2J3 OR2J3 KCNJ6 KCNJ6 HTR2A HTR2A P2RY1 P2RY1 HTR1D HTR1D ADORA1 ADORA1 ADCY8 ADCY8 LOC694161 LOC694161 ARHGEF11 ARHGEF11 ADRB1 ADRB1 GNGT1 GNGT1 ADCY3 ADCY3 GNA12 GNA12 GNG11 GNG11 GNG3 GNG3 ADRA1A ADRA1A ARHGEF12 ARHGEF12 F2R F2R KCNJ10 KCNJ10 CBY3 CBY3 CASR CASR HTR7 HTR7 TAS2R9 TAS2R9 ADORA2B ADORA2B GNAQ GNAQ PLCB4 PLCB4 GABBR2 GABBR2 GNA15 GNA15 OR4N5 OR4N5 HTR6 HTR6 ADRA1D ADRA1D TAS2R10 TAS2R10 TAS2R13 TAS2R13 GNG4 GNG4 KCNJ5 KCNJ5 CHRM2 CHRM2 HTR2C HTR2C GNB1 GNB1 CYSLTR2 CYSLTR2 KCNJ9 KCNJ9 HTR5A HTR5A GNG7 GNG7 PLCB2 PLCB2 ADCY9 ADCY9 TAS2R5 TAS2R5 TAS2R7 TAS2R7 ADCY1 ADCY1 CNR1 CNR1 TAS2R3 TAS2R3 TAS2R1 TAS2R1 KCNJ15 KCNJ15 GNB2 GNB2 F2RL3 F2RL3 OR7D4 OR7D4 TAS2R20 TAS2R20 GNAL GNAL LOC114669749 LOC114669749 TAS2R8 TAS2R8 CALY CALY LPAR3 LPAR3 LPAR5 LPAR5 TAS2R16 TAS2R16 PDC PDC SSTR3 SSTR3 TAS1R3 TAS1R3 LPAR4 LPAR4 GNAT3 GNAT3 ADRA1B ADRA1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTGER2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa)
PRSS2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (295 aa)
OR8S1Olfactory receptor family 8 subfamily S member 1. (358 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
GNAZGuanine nucleotide-binding protein G(Z) subunit alpha. (355 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (415 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
TAS1R2Taste receptor type 1 member 2; Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (By similarity). (839 aa)
GPRC6AG protein-coupled receptor class C group 6 member A. (928 aa)
ADORA3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (347 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
DRD1D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
PTGER1Prostaglandin E receptor 1. (581 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
TAS2R40Taste receptor type 2. (323 aa)
PDCLPhosducin-like protein. (301 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1. (501 aa)
RGS3Regulator of G protein signaling 3. (1085 aa)
GRM5Metabotropic glutamate receptor 5 isoform a. (1212 aa)
LOC694289Uncharacterized protein. (394 aa)
AKAP13A-kinase anchoring protein 13. (2899 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1120 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (337 aa)
CHRM5Muscarinic acetylcholine receptor M5; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily. (532 aa)
RGS9Regulator of G protein signaling 9. (658 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (490 aa)
GNA13G protein subunit alpha 13. (409 aa)
GNA14G protein subunit alpha 14. (355 aa)
CHRM1Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. (460 aa)
PTGER3Prostaglandin E receptor 3. (460 aa)
GNB5G protein subunit beta 5. (395 aa)
MTNR1AMelatonin receptor 1A; Belongs to the G-protein coupled receptor 1 family. (352 aa)
TAS1R1Taste 1 receptor member 1. (841 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha isoform a. (354 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1. (355 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1155 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
TAS2R4Taste receptor type 2. (299 aa)
DRD3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (400 aa)
F2RL2Coagulation factor II thrombin receptor like 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
GNAI1G protein subunit alpha i1. (422 aa)
ADRB3Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis. (418 aa)
KCNJ16Potassium voltage-gated channel subfamily J member 16. (458 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (962 aa)
OR2J3Olfactory receptor. (311 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
HTR2A5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (471 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
HTR1D5-hydroxytryptamine receptor 1D. (377 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
LOC694161Taste receptor type 2. (309 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1562 aa)
ADRB1Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (478 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
GNA12G protein subunit alpha 12. (463 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
ADRA1AAdrenoceptor alpha 1A. (445 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
KCNJ10ATP-sensitive inward rectifier potassium channel 10. (379 aa)
CBY3Uncharacterized protein. (242 aa)
CASRCalcium sensing receptor. (1078 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (445 aa)
TAS2R9Taste receptor type 2 member 9; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). (310 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
GNA15Uncharacterized protein. (414 aa)
OR4N5Olfactory receptor. (308 aa)
HTR6G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (440 aa)
ADRA1DAdrenoceptor alpha 1D. (570 aa)
TAS2R10Taste receptor type 2. (307 aa)
TAS2R13Taste receptor type 2. (303 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (469 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (492 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
CYSLTR2Cysteinyl leukotriene receptor 2. (332 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (468 aa)
HTR5A5-hydroxytryptamine receptor 5A. (357 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1302 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
TAS2R5Taste 2 receptor member 5; Belongs to the G-protein coupled receptor T2R family. (386 aa)
TAS2R7Taste receptor type 2 member 7; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). (318 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (By similarity). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. In [...] (472 aa)
TAS2R3Taste receptor type 2. (316 aa)
TAS2R1Taste receptor type 2. (299 aa)
KCNJ15Uncharacterized protein. (375 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (385 aa)
OR7D4Olfactory receptor. (350 aa)
TAS2R20Taste receptor type 2. (309 aa)
GNALUncharacterized protein. (450 aa)
LOC114669749Protein chibby homolog 3. (242 aa)
TAS2R8Taste receptor type 2. (318 aa)
CALYNeuron-specific vesicular protein calcyon. (218 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
TAS2R16Taste receptor type 2. (291 aa)
PDCPhosducin. (246 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (418 aa)
TAS1R3Taste 1 receptor member 3. (852 aa)
LPAR4Uncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
ADRA1BAdrenoceptor alpha 1B. (518 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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