(75 nodes) Mixed, incl. Photoreceptor outer segment, and Receptor guanylyl cyclase signaling pathway network (Macaca mulatta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BGLAP	Osteocalcin; Belongs to the mitochondrial carrier (TC 2.A.29) family. (367 aa)
	CDHR1	Cadherin related family member 1. (859 aa)
	RGR	Retinal G protein coupled receptor; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (291 aa)
	PDE6B	Phosphodiesterase. (839 aa)
	OPN4	Opsin 4. (489 aa)
	GUCA1B	Guanylate cyclase activator 1B. (205 aa)
	TEAD4	TUB like protein 3; Belongs to the TUB family. (728 aa)
	PCARE	Photoreceptor cilium actin regulator. (1295 aa)
	PDE6A	Phosphodiesterase. (860 aa)
	NYX	Nyctalopin. (480 aa)
	GUCA1A	Guanylate cyclase activator 1A. (202 aa)
	OPN3	Opsin 3; Belongs to the G-protein coupled receptor 1 family. (481 aa)
	GNAT2	G protein subunit alpha transducin 2. (354 aa)
	OPN1LW	Opsin 1, long wave sensitive. (364 aa)
	GRK7	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa)
	GRK1	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (535 aa)
	NPPA	Natriuretic peptide A. (153 aa)
	NPR1	Guanylate cyclase. (1061 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1970 aa)
	ATXN10	Uncharacterized protein. (545 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (1232 aa)
	GUCY2F	Guanylate cyclase. (1108 aa)
	OPN5	Opsin 5; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	ABCA4	ATP binding cassette subfamily A member 4. (2273 aa)
	ARR3	Arrestin 3. (388 aa)
	PDE6C	Phosphodiesterase. (858 aa)
	NPR2	Guanylate cyclase. (1047 aa)
	CNGA4	Cyclic nucleotide gated channel subunit alpha 4. (575 aa)
	CACNA2D4	Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1137 aa)
	CNGB3	Cyclic nucleotide gated channel subunit beta 3. (808 aa)
	CNGB1	Cyclic nucleotide-binding domain-containing protein. (1247 aa)
	GUCA2B	Guanylate cyclase activator 2B. (112 aa)
	NR2E3	Nuclear receptor subfamily 2 group E member 3. (410 aa)
	GNAT1	G protein subunit alpha i2. (350 aa)
	RRH	Retinal pigment epithelium-derived rhodopsin homolog; Belongs to the G-protein coupled receptor 1 family. (337 aa)
	SLC24A1	Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1093 aa)
	LRIT3	Leucine rich repeat, Ig-like and transmembrane domains 3. (676 aa)
	SAG	S-antigen visual arrestin. (405 aa)
	ADAM9	ADAM metallopeptidase domain 9. (848 aa)
	PROM1	Prominin 1. (855 aa)
	CNGA3	Cyclic nucleotide gated channel subunit alpha 3. (694 aa)
	BEST1	Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (604 aa)
	SEMA4A	Semaphorin 4A; Belongs to the semaphorin family. (760 aa)
	ELOVL4	Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical r [...] (381 aa)
	RP1L1	RP1 like 1. (1566 aa)
	TRPM1	Transient receptor potential cation channel subfamily M member 1. (1642 aa)
	MEGF10	Multiple EGF like domains 10. (1137 aa)
	CNGA1	Cyclic nucleotide gated channel subunit alpha 1. (759 aa)
	PDE6G	Phosphodiesterase 6G. (87 aa)
	CERKL	Ceramide kinase like. (539 aa)
	ZNF875	Zinc finger protein 875. (639 aa)
	MFRP	Membrane frizzled-related protein. (640 aa)
	EFEMP1	EGF containing fibulin extracellular matrix protein 1. (516 aa)
	CRX	Cone-rod homeobox. (299 aa)
	RHO	Rhodopsin. (348 aa)
	CNGA2	Cyclic nucleotide gated channel subunit alpha 2. (664 aa)
	PDE6H	Phosphodiesterase 6H. (85 aa)
	PRCD	Progressive rod-cone degeneration protein. (54 aa)
	OPN1MW3	G_PROTEIN_RECEP_F1_2 domain-containing protein. (363 aa)
	TMIGD1	Uncharacterized protein. (262 aa)
	C8H8orf37	Chromosome 8 C8orf37 homolog. (207 aa)
	CEP78	Centrosomal protein 78. (809 aa)
	GUCY2D	Guanylate cyclase. (1145 aa)
	NPR3	Natriuretic peptide receptor 3. (541 aa)
	NPPC	C-type natriuretic peptide. (126 aa)
	GUCA2A	Uncharacterized protein. (115 aa)
	CFAP410	Cilia and flagella associated protein 410. (356 aa)
	GUCA1C	Guanylate cyclase activator 1C. (210 aa)
	CABP4	Calcium binding protein 4. (303 aa)
	KCNV2	Uncharacterized protein; Belongs to the potassium channel family. (545 aa)
	ENSMMUP00000077940	Uncharacterized protein. (113 aa)
	PRPH2	Peripherin 2. (346 aa)
	ROM1	Rod outer segment membrane protein 1. (351 aa)
	NRL	Neural retina leucine zipper. (239 aa)
	NPPB	Natriuretic peptide B. (160 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA4	BEST1	ENSMMUP00000018214	ENSMMUP00000037332	ATP binding cassette subfamily A member 4.	Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family.	0.659
ABCA4	C8H8orf37	ENSMMUP00000018214	ENSMMUP00000071881	ATP binding cassette subfamily A member 4.	Chromosome 8 C8orf37 homolog.	0.618
ABCA4	CDHR1	ENSMMUP00000018214	ENSMMUP00000000886	ATP binding cassette subfamily A member 4.	Cadherin related family member 1.	0.579
ABCA4	CERKL	ENSMMUP00000018214	ENSMMUP00000052028	ATP binding cassette subfamily A member 4.	Ceramide kinase like.	0.600
ABCA4	CFAP410	ENSMMUP00000018214	ENSMMUP00000075977	ATP binding cassette subfamily A member 4.	Cilia and flagella associated protein 410.	0.420
ABCA4	CNGA1	ENSMMUP00000018214	ENSMMUP00000050524	ATP binding cassette subfamily A member 4.	Cyclic nucleotide gated channel subunit alpha 1.	0.509
ABCA4	CNGA3	ENSMMUP00000018214	ENSMMUP00000036262	ATP binding cassette subfamily A member 4.	Cyclic nucleotide gated channel subunit alpha 3.	0.531
ABCA4	CNGB1	ENSMMUP00000018214	ENSMMUP00000024114	ATP binding cassette subfamily A member 4.	Cyclic nucleotide-binding domain-containing protein.	0.521
ABCA4	CNGB3	ENSMMUP00000018214	ENSMMUP00000023519	ATP binding cassette subfamily A member 4.	Cyclic nucleotide gated channel subunit beta 3.	0.693
ABCA4	CRX	ENSMMUP00000018214	ENSMMUP00000062943	ATP binding cassette subfamily A member 4.	Cone-rod homeobox.	0.578
ABCA4	EFEMP1	ENSMMUP00000018214	ENSMMUP00000059665	ATP binding cassette subfamily A member 4.	EGF containing fibulin extracellular matrix protein 1.	0.489
ABCA4	ELOVL4	ENSMMUP00000018214	ENSMMUP00000041938	ATP binding cassette subfamily A member 4.	Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical r [...]	0.790
ABCA4	GNAT1	ENSMMUP00000018214	ENSMMUP00000026481	ATP binding cassette subfamily A member 4.	G protein subunit alpha i2.	0.414
ABCA4	GNAT2	ENSMMUP00000018214	ENSMMUP00000007670	ATP binding cassette subfamily A member 4.	G protein subunit alpha transducin 2.	0.520
ABCA4	GUCY2D	ENSMMUP00000018214	ENSMMUP00000073530	ATP binding cassette subfamily A member 4.	Guanylate cyclase.	0.611
ABCA4	KCNV2	ENSMMUP00000018214	ENSMMUP00000077822	ATP binding cassette subfamily A member 4.	Uncharacterized protein; Belongs to the potassium channel family.	0.519
ABCA4	MERTK	ENSMMUP00000018214	ENSMMUP00000013160	ATP binding cassette subfamily A member 4.	MER proto-oncogene, tyrosine kinase.	0.513
ABCA4	NR2E3	ENSMMUP00000018214	ENSMMUP00000025333	ATP binding cassette subfamily A member 4.	Nuclear receptor subfamily 2 group E member 3.	0.554
ABCA4	PDE6A	ENSMMUP00000018214	ENSMMUP00000006320	ATP binding cassette subfamily A member 4.	Phosphodiesterase.	0.542
ABCA4	PDE6B	ENSMMUP00000018214	ENSMMUP00000004374	ATP binding cassette subfamily A member 4.	Phosphodiesterase.	0.621