36 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	SNCB	Beta-synuclein; Belongs to the synuclein family. (139 aa)
	DRD4	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (418 aa)
	SLC6A4	Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. (630 aa)
	TH	Tyrosine hydroxylase. (501 aa)
	CALB1	Calbindin 1. (261 aa)
	SYN3	Synapsin III. (580 aa)
	GAP43	Growth associated protein 43. (238 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	CNP	Uncharacterized protein. (499 aa)
	DBH	Dopamine beta-hydroxylase. (620 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (323 aa)
	MAP2	Microtubule-associated protein. (1827 aa)
	MAOA	Amine oxidase. (969 aa)
	DDC	Aromatic-L-amino-acid decarboxylase. (480 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
	PLP2	Proteolipid protein 2. (237 aa)
	SNCAIP	Synuclein alpha interacting protein. (1017 aa)
	MOG	Ig-like domain-containing protein. (294 aa)
	NES	Nestin; Belongs to the intermediate filament family. (1721 aa)
	MBP	Myelin basic protein. (437 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (462 aa)
	PLP1	Uncharacterized protein. (281 aa)
	UCHL1	Ubiquitin carboxyl-terminal hydrolase. (343 aa)
	LRTOMT	Transmembrane O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (By similarity). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity). (295 aa)
	SNCA	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (146 aa)
	SNCG	Gamma-synuclein; Belongs to the synuclein family. (296 aa)
	ACHE	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family. (848 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (631 aa)
	SOX10	SRY-box transcription factor 10. (467 aa)
	SYP	Synaptophysin. (401 aa)
	COMT	Catechol-O-methyltransferase. (376 aa)
	PVALB	Parvalbumin; Belongs to the parvalbumin family. (178 aa)
	SDF4	Stromal cell derived factor 4. (484 aa)
	MAOB	Amine oxidase. (520 aa)
	SYN1	Synapsin-1 isoform Ia. (705 aa)
	PNMT	Phenylethanolamine N-methyltransferase. (282 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACHE	CALB1	ENSMMUP00000063657	ENSMMUP00000008765	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family.	Calbindin 1.	0.697
ACHE	COMT	ENSMMUP00000063657	ENSMMUP00000066080	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family.	Catechol-O-methyltransferase.	0.464
ACHE	DBH	ENSMMUP00000063657	ENSMMUP00000022635	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family.	Dopamine beta-hydroxylase.	0.424
ACHE	MAOA	ENSMMUP00000063657	ENSMMUP00000025612	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family.	Amine oxidase.	0.576
ACHE	MAOB	ENSMMUP00000063657	ENSMMUP00000069352	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family.	Amine oxidase.	0.710
ACHE	PVALB	ENSMMUP00000063657	ENSMMUP00000068520	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family.	Parvalbumin; Belongs to the parvalbumin family.	0.749
ACHE	SNCA	ENSMMUP00000063657	ENSMMUP00000061274	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family.	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	0.443
ACHE	SYP	ENSMMUP00000063657	ENSMMUP00000066003	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family.	Synaptophysin.	0.423
ACHE	TH	ENSMMUP00000063657	ENSMMUP00000005218	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family.	Tyrosine hydroxylase.	0.611
CALB1	ACHE	ENSMMUP00000008765	ENSMMUP00000063657	Calbindin 1.	Uncharacterized protein; Belongs to the type-B carboxylesterase/lipase family.	0.697
CALB1	GFAP	ENSMMUP00000008765	ENSMMUP00000046183	Calbindin 1.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.757
CALB1	MAP2	ENSMMUP00000008765	ENSMMUP00000024664	Calbindin 1.	Microtubule-associated protein.	0.617
CALB1	MBP	ENSMMUP00000008765	ENSMMUP00000043839	Calbindin 1.	Myelin basic protein.	0.411
CALB1	NES	ENSMMUP00000008765	ENSMMUP00000042208	Calbindin 1.	Nestin; Belongs to the intermediate filament family.	0.584
CALB1	OLIG2	ENSMMUP00000008765	ENSMMUP00000023227	Calbindin 1.	Oligodendrocyte transcription factor 2.	0.439
CALB1	PVALB	ENSMMUP00000008765	ENSMMUP00000068520	Calbindin 1.	Parvalbumin; Belongs to the parvalbumin family.	0.956
CALB1	SDF4	ENSMMUP00000008765	ENSMMUP00000068610	Calbindin 1.	Stromal cell derived factor 4.	0.912
CALB1	SNCA	ENSMMUP00000008765	ENSMMUP00000061274	Calbindin 1.	Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]	0.515
CALB1	SNCG	ENSMMUP00000008765	ENSMMUP00000061940	Calbindin 1.	Gamma-synuclein; Belongs to the synuclein family.	0.447
CALB1	SYN1	ENSMMUP00000008765	ENSMMUP00000070394	Calbindin 1.	Synapsin-1 isoform Ia.	0.511