(6 nodes) Small protein activating enzyme binding, and PINIT domain network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UBA2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (640 aa)
	PIAS1	Protein inhibitor of activated STAT protein 1. (651 aa)
	SUMO1	Small ubiquitin-related modifier. (101 aa)
	SAE1	ThiF domain-containing protein. (362 aa)
	UBE2I	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (260 aa)
	LOC699185	Small ubiquitin-related modifier. (101 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC699185	PIAS1	ENSMMUP00000074231	ENSMMUP00000015356	Small ubiquitin-related modifier.	Protein inhibitor of activated STAT protein 1.	0.938
LOC699185	SAE1	ENSMMUP00000074231	ENSMMUP00000059881	Small ubiquitin-related modifier.	ThiF domain-containing protein.	0.959
LOC699185	SUMO1	ENSMMUP00000074231	ENSMMUP00000045844	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.562
LOC699185	UBA2	ENSMMUP00000074231	ENSMMUP00000007742	Small ubiquitin-related modifier.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.936
LOC699185	UBE2I	ENSMMUP00000074231	ENSMMUP00000065615	Small ubiquitin-related modifier.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.903
PIAS1	LOC699185	ENSMMUP00000015356	ENSMMUP00000074231	Protein inhibitor of activated STAT protein 1.	Small ubiquitin-related modifier.	0.938
PIAS1	SAE1	ENSMMUP00000015356	ENSMMUP00000059881	Protein inhibitor of activated STAT protein 1.	ThiF domain-containing protein.	0.753
PIAS1	SUMO1	ENSMMUP00000015356	ENSMMUP00000045844	Protein inhibitor of activated STAT protein 1.	Small ubiquitin-related modifier.	0.972
PIAS1	UBA2	ENSMMUP00000015356	ENSMMUP00000007742	Protein inhibitor of activated STAT protein 1.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.724
PIAS1	UBE2I	ENSMMUP00000015356	ENSMMUP00000065615	Protein inhibitor of activated STAT protein 1.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.959
SAE1	LOC699185	ENSMMUP00000059881	ENSMMUP00000074231	ThiF domain-containing protein.	Small ubiquitin-related modifier.	0.959
SAE1	PIAS1	ENSMMUP00000059881	ENSMMUP00000015356	ThiF domain-containing protein.	Protein inhibitor of activated STAT protein 1.	0.753
SAE1	SUMO1	ENSMMUP00000059881	ENSMMUP00000045844	ThiF domain-containing protein.	Small ubiquitin-related modifier.	0.993
SAE1	UBA2	ENSMMUP00000059881	ENSMMUP00000007742	ThiF domain-containing protein.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.997
SAE1	UBE2I	ENSMMUP00000059881	ENSMMUP00000065615	ThiF domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.971
SUMO1	LOC699185	ENSMMUP00000045844	ENSMMUP00000074231	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.562
SUMO1	PIAS1	ENSMMUP00000045844	ENSMMUP00000015356	Small ubiquitin-related modifier.	Protein inhibitor of activated STAT protein 1.	0.972
SUMO1	SAE1	ENSMMUP00000045844	ENSMMUP00000059881	Small ubiquitin-related modifier.	ThiF domain-containing protein.	0.993
SUMO1	UBA2	ENSMMUP00000045844	ENSMMUP00000007742	Small ubiquitin-related modifier.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.993
SUMO1	UBE2I	ENSMMUP00000045844	ENSMMUP00000065615	Small ubiquitin-related modifier.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.999