STRINGSTRING
PIF1 PIF1 TERF2IP TERF2IP ZSCAN4 ZSCAN4 NEDD8 NEDD8 RFC1 RFC1 PCNA PCNA DNA2 DNA2 RIF1 RIF1 ENSMMUP00000064616 ENSMMUP00000064616 SHLD3 SHLD3 NSMCE2 NSMCE2 XRCC4 XRCC4 RUVBL2 RUVBL2 ENSMMUP00000069269 ENSMMUP00000069269 XRCC3 XRCC3 RAD51 RAD51 ZNF827 ZNF827 TPRKB TPRKB EXO1 EXO1 RUVBL1 RUVBL1 MAD2L2 MAD2L2 RPA1 RPA1 UPF1 UPF1 SP100 SP100 APEX1 APEX1 LTO1 LTO1 RAD50 RAD50 UCHL5 UCHL5 NOP10 NOP10 ERCC1 ERCC1 NFRKB NFRKB DCLRE1A DCLRE1A TERF2 TERF2 ERCC4 ERCC4 PRKDC PRKDC STN1 STN1 MCRS1 MCRS1 TERT TERT ACD ACD ACTL6A ACTL6A RAD51C RAD51C WRAP53 WRAP53 RPA3 RPA3 INO80D INO80D XRCC5 XRCC5 CTC1 CTC1 INO80B INO80B FBXO4 FBXO4 SMC5 SMC5 SMC6 SMC6 ATR ATR SLX4 SLX4 SLX1A SLX1A ATM ATM NHP2 NHP2 ACTR8 ACTR8 BLM BLM DCLRE1B DCLRE1B SMARCAL1 SMARCAL1 INO80E INO80E POT1 POT1 CCNE1 CCNE1 F7DM39_MACMU F7DM39_MACMU PARP1 PARP1 INO80 INO80 DKC1 DKC1 TELO2 TELO2 XRCC6 XRCC6 SHLD1 SHLD1 LOC114669758 LOC114669758 PINX1 PINX1 GAR1 GAR1 TEP1 TEP1 PARP3 PARP3 TFPT TFPT WRN WRN ZBTB48 ZBTB48 F6YRS3_MACMU F6YRS3_MACMU RTEL1 RTEL1 LOC106992761 LOC106992761 CCNE2 CCNE2 NBN NBN BRCA2 BRCA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (707 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1. (400 aa)
ZSCAN4Zinc finger and SCAN domain containing 4. (433 aa)
NEDD8TERF1 interacting nuclear factor 2. (482 aa)
RFC1Replication factor C subunit 1. (1146 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
DNA2DNA replication helicase/nuclease 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (1316 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
ENSMMUP00000064616Uncharacterized protein. (219 aa)
SHLD3Shieldin complex subunit 3. (250 aa)
NSMCE2E3 SUMO-protein ligase NSE2. (246 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (497 aa)
ENSMMUP00000069269Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (437 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (380 aa)
ZNF827Zinc finger protein 827. (1349 aa)
TPRKBTP53RK binding protein; Belongs to the CGI121/TPRKB family. (213 aa)
EXO1Exonuclease 1. (846 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (212 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
UPF1UPF1 RNA helicase and ATPase. (1129 aa)
SP100SP100 nuclear antigen. (870 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
LTO1LTO1 maturation factor of ABCE1. (192 aa)
RAD50Zinc-hook domain-containing protein. (1411 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (472 aa)
NOP10H/ACA ribonucleoprotein complex subunit 3. (64 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (442 aa)
NFRKBNuclear factor related to kappaB binding protein. (1433 aa)
DCLRE1ADNA cross-link repair 1A. (1039 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
MCRS1Microspherule protein 1. (475 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1130 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (455 aa)
ACTL6AActin-like protein 6A isoform 1; Belongs to the actin family. (429 aa)
RAD51CRAD51 paralog C. (367 aa)
WRAP53Telomerase Cajal body protein 1. (548 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
INO80DINO80 complex subunit D. (1027 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
CTC1CST telomere replication complex component 1. (1267 aa)
INO80BINO80 complex subunit B. (356 aa)
FBXO4F-box protein 4. (490 aa)
SMC5SMC_N domain-containing protein. (1201 aa)
SMC6Structural maintenance of chromosomes 6. (1092 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1668 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (437 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
BLMBLM RecQ like helicase. (1416 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa)
INO80EUncharacterized protein. (243 aa)
POT1Protection of telomeres 1. (658 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
F7DM39_MACMUUncharacterized protein. (143 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
INO80Putative DNA helicase INO80 complex-like protein 1. (1556 aa)
DKC1PUA domain-containing protein. (556 aa)
TELO2Telomere maintenance 2. (936 aa)
XRCC6X-ray repair cross-complementing protein 6. (609 aa)
SHLD1Shieldin complex subunit 1. (228 aa)
LOC114669758Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (440 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (452 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (217 aa)
TEP1Telomerase associated protein 1. (2622 aa)
PARP3Poly [ADP-ribose] polymerase. (532 aa)
TFPTTCF3 fusion partner. (253 aa)
WRNWRN RecQ like helicase. (1426 aa)
ZBTB48Zinc finger and BTB domain containing 48. (760 aa)
F6YRS3_MACMUKu domain-containing protein. (326 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1297 aa)
LOC106992761HSR domain-containing protein. (317 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (426 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
BRCA2BRCA2 DNA repair associated. (3377 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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