STRINGSTRING
HEY2 HEY2 SNAI1 SNAI1 HECTD1 HECTD1 ADM ADM SOCS3 SOCS3 PDGFB PDGFB TMED2 TMED2 NCOA1 NCOA1 NSDHL NSDHL EOMES EOMES BIRC6 BIRC6 FBXW8 FBXW8 IGF2 IGF2 WNT7B WNT7B E2F8 E2F8 OVOL2 OVOL2 SPINT1 SPINT1 TTPA TTPA HS6ST1 HS6ST1 SOX15 SOX15 EGLN1 EGLN1 MDFI MDFI CDX2 CDX2 FZD5 FZD5 TTPAL TTPAL RTL5 RTL5 VASH1 VASH1 WNT2 WNT2 MED1 MED1 ENSMMUP00000062295 ENSMMUP00000062295 AKT1 AKT1 GGNBP2 GGNBP2 HIF1A HIF1A HEY1 HEY1 EPAS1 EPAS1 LIF LIF CEBPB CEBPB CITED2 CITED2 FGFR2 FGFR2 ZFP36L1 ZFP36L1 PLK4 PLK4 ZNF568 ZNF568 STK3 STK3 GRB2 GRB2 LEF1 LEF1 NR2F2 NR2F2 CITED4 CITED4 ST14 ST14 GATA2 GATA2 CASP8 CASP8 TFEB TFEB ZFAT ZFAT IL10 IL10 NODAL NODAL E2F7 E2F7 GCM1 GCM1 SP3 SP3 PRDM1 PRDM1 SETD2 SETD2 GRHL2 GRHL2 TRIM28 TRIM28 KRT19 KRT19 CSF2 CSF2 RSPO3 RSPO3 PLCD3 PLCD3 CDX4 CDX4 STK4 STK4 CCN1 CCN1 MAPK1 MAPK1 BMP5 BMP5 VASH2 VASH2 HAND1 HAND1 BPTF BPTF PKD2 PKD2 TAF10 TAF10 PCDH12 PCDH12 JUNB JUNB RTL1 RTL1 BMP7 BMP7 PKD1 PKD1 ASCL2 ASCL2 ARNT ARNT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
HECTD1E3 ubiquitin-protein ligase HECTD1. (2610 aa)
ADMAdrenomedullin. (211 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
TMED2GOLD domain-containing protein. (208 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
NSDHLSterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Belongs to the 3-beta-HSD family. (373 aa)
EOMESEomesodermin. (703 aa)
BIRC6Baculoviral IAP repeat containing 6. (4891 aa)
FBXW8F-box and WD repeat domain containing 8. (598 aa)
IGF2Insulin like growth factor 2. (244 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
E2F8E2F transcription factor 8. (867 aa)
OVOL2Transcription factor Ovo-like 2. (275 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (667 aa)
TTPACRAL-TRIO domain-containing protein. (278 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
SOX15SRY-box transcription factor 15. (233 aa)
EGLN1Uncharacterized protein. (426 aa)
MDFIMyoD family inhibitor. (246 aa)
CDX2Caudal-type homeobox protein 2. (313 aa)
FZD5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
TTPALAlpha-tocopherol transfer protein-like protein. (342 aa)
RTL5Retrotransposon gag domain-containing protein 4. (567 aa)
VASH1Uncharacterized protein. (447 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
ENSMMUP00000062295RNase H domain-containing protein. (439 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GGNBP2Gametogenetin binding protein 2. (739 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform a. (304 aa)
EPAS1Endothelial PAS domain protein 1. (875 aa)
LIFLIF interleukin 6 family cytokine. (206 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
ZFP36L1ZFP36 ring finger protein like 1. (344 aa)
PLK4Polo like kinase 4. (970 aa)
ZNF568Zinc finger protein 568. (646 aa)
STK3Uncharacterized protein. (519 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
CITED4Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (232 aa)
ST14Suppression of tumorigenicity 14. (962 aa)
GATA2GATA binding protein 2. (480 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
TFEBTranscription factor EB. (490 aa)
ZFATZinc finger and AT-hook domain containing. (1375 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
NODALNodal growth differentiation factor. (347 aa)
E2F7E2F transcription factor 7. (910 aa)
GCM1Glial cells missing transcription factor 1. (436 aa)
SP3Sp3 transcription factor. (796 aa)
PRDM1PR/SET domain 1. (820 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2565 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
TRIM28Tripartite motif containing 28. (834 aa)
KRT19Keratin, type I cytoskeletal 19; Belongs to the intermediate filament family. (400 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
RSPO3R-spondin 3. (273 aa)
PLCD3Phosphoinositide phospholipase C. (785 aa)
CDX4Caudal-type homeobox protein 4. (284 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
CCN1Cellular communication network factor 1. (381 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
VASH2Vasohibin 2. (355 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
BPTFBromodomain PHD finger transcription factor. (3156 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (969 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
PCDH12Protocadherin 12. (1184 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (322 aa)
RTL1Retrotransposon Gag like 1. (1359 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4298 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
ARNTUncharacterized protein. (786 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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