STRINGSTRING
PDGFA PDGFA NF1 NF1 EXT1 EXT1 LDB1 LDB1 FGF7 FGF7 HDAC1 HDAC1 LOC694289 LOC694289 DKK1 DKK1 FUZ FUZ SMO SMO KRT25 KRT25 ZDHHC21 ZDHHC21 ATP7A ATP7A NSUN2 NSUN2 KRT71 KRT71 GORAB GORAB INTU INTU SOSTDC1 SOSTDC1 NOTCH1 NOTCH1 EDA EDA CD109 CD109 KRT84 KRT84 FOXN1 FOXN1 DSG4 DSG4 PUM2 PUM2 EDAR EDAR LGR4 LGR4 LRP4 LRP4 TP63 TP63 FOXE1 FOXE1 ZMPSTE24 ZMPSTE24 TMEM79 TMEM79 ERCC2 ERCC2 FGFR2 FGFR2 NOM1 NOM1 ACVR1B ACVR1B DNASE1L2 DNASE1L2 FGF10 FGF10 SAV1 SAV1 RELA RELA GLI2 GLI2 HDAC2 HDAC2 IGFBP5 IGFBP5 LGR5 LGR5 FOXQ1 FOXQ1 HOXC13 HOXC13 CTNNB1 CTNNB1 PIAS4 PIAS4 ALX4 ALX4 TGFB2 TGFB2 SNAI1 SNAI1 SHH SHH DLX3 DLX3 PLA2G10 PLA2G10 FZD3 FZD3 SOS1 SOS1 NSDHL NSDHL TRPC4AP TRPC4AP WNT10A WNT10A SOX18 SOX18 BCL2 BCL2 APCDD1 APCDD1 LDB2 LDB2 SOX9 SOX9 INHBA INHBA KRT27 KRT27 KRT28 KRT28 LHX2 LHX2 TNFRSF19 TNFRSF19 FST FST FZD6 FZD6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (249 aa)
NF1Neurofibromin 1. (2867 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
LDB1LIM domain-binding protein 1 isoform 1. (411 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
LOC694289Uncharacterized protein. (394 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
FUZFuzzy planar cell polarity protein. (445 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
KRT25Keratin 25; Belongs to the intermediate filament family. (450 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (765 aa)
KRT71Keratin 71; Belongs to the intermediate filament family. (525 aa)
GORABGolgin, RAB6 interacting. (369 aa)
INTUInturned planar cell polarity protein. (942 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
NOTCH1Notch receptor 1. (2556 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
CD109CD109 molecule. (1364 aa)
KRT84Keratin 84; Belongs to the intermediate filament family. (600 aa)
FOXN1Forkhead box N1. (648 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1040 aa)
PUM2Pumilio RNA binding family member 2. (1141 aa)
EDAREctodysplasin A receptor. (465 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1905 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
FOXE1Forkhead box E1. (372 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
TMEM79Transmembrane protein 79. (394 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit isoform 1. (760 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
NOM1MI domain-containing protein. (863 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (278 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
GLI2GLI family zinc finger 2. (1569 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
FOXQ1Forkhead box Q1. (403 aa)
HOXC13Homeobox C13. (329 aa)
CTNNB1Catenin beta-1. (781 aa)
PIAS4Protein inhibitor of activated STAT 4. (561 aa)
ALX4ALX homeobox 4. (409 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
DLX3Distal-less homeobox 3. (287 aa)
PLA2G10Phospholipase A(2). (165 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
NSDHLSterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Belongs to the 3-beta-HSD family. (373 aa)
TRPC4APTransient receptor potential cation channel subfamily C member 4 associated protein. (822 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SOX18SRY-box transcription factor 18. (384 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
APCDD1Adenomatosis polyposis down-regulated 1 protein. (514 aa)
LDB2LID domain-containing protein. (374 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
INHBAInhibin subunit beta A. (426 aa)
KRT27Keratin 27; Belongs to the intermediate filament family. (459 aa)
KRT28Keratin 28; Belongs to the intermediate filament family. (464 aa)
LHX2LIM/homeobox protein Lhx2. (406 aa)
TNFRSF19TNF receptor superfamily member 19. (417 aa)
FSTFollistatin. (344 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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