(32 nodes) Fibronectin binding network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LACRT	Lacritin. (137 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (703 aa)
	CCDC80	Coiled-coil domain-containing protein 80. (950 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (741 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	CPN2	Carboxypeptidase N subunit 2. (545 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (354 aa)
	TNFAIP6	Tumor necrosis factor-inducible gene 6 protein. (277 aa)
	MYOC	Myocilin. (491 aa)
	IGFBP3	Insulin-like growth factor-binding protein 3 isoform b. (291 aa)
	SFRP2	Secreted frizzled-related protein 2. (295 aa)
	ITGAV	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
	LOXL3	Lysyl oxidase like 3. (753 aa)
	LRRC15	Leucine rich repeat containing 15. (581 aa)
	CTSL	Cathepsin L; Belongs to the peptidase C1 family. (333 aa)
	HSD17B12	Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
	CCN2	Cellular communication network factor 2. (349 aa)
	MMP2	72 kDa type IV collagenase isoform a preproprotein. (660 aa)
	ENSMMUP00000054262	Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
	SSC5D	Scavenger receptor cysteine rich family member with 5 domains. (1554 aa)
	IGFBP5	Insulin-like growth factor-binding protein 5. (272 aa)
	PLEKHA2	Pleckstrin homology domain-containing family A member 2. (425 aa)
	IGFBP6	Insulin-like growth factor-binding protein 6. (239 aa)
	SDC4	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
	GP5	Glycoprotein V platelet. (561 aa)
	C6orf15	Uncharacterized protein C6orf15 homolog. (314 aa)
	LILRB4	Leukocyte immunoglobulin like receptor B4. (423 aa)
	MFAP2	ShKT domain-containing protein. (183 aa)
	EPHA1	EPH receptor A1. (978 aa)
	FSTL3	Uncharacterized protein. (436 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC80	LOXL3	ENSMMUP00000004083	ENSMMUP00000036437	Coiled-coil domain-containing protein 80.	Lysyl oxidase like 3.	0.679
CCN2	MMP2	ENSMMUP00000045240	ENSMMUP00000051376	Cellular communication network factor 2.	72 kDa type IV collagenase isoform a preproprotein.	0.491
CCN2	MYOC	ENSMMUP00000045240	ENSMMUP00000017941	Cellular communication network factor 2.	Myocilin.	0.582
CCN2	SDC4	ENSMMUP00000045240	ENSMMUP00000070683	Cellular communication network factor 2.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.463
CCN2	THBS1	ENSMMUP00000045240	ENSMMUP00000007925	Cellular communication network factor 2.	Thrombospondin 1.	0.675
CTSL	CTSS	ENSMMUP00000038922	ENSMMUP00000013979	Cathepsin L; Belongs to the peptidase C1 family.	Cathepsin S; Belongs to the peptidase C1 family.	0.426
CTSS	CTSL	ENSMMUP00000013979	ENSMMUP00000038922	Cathepsin S; Belongs to the peptidase C1 family.	Cathepsin L; Belongs to the peptidase C1 family.	0.426
CTSS	ITGB3	ENSMMUP00000013979	ENSMMUP00000004380	Cathepsin S; Belongs to the peptidase C1 family.	Integrin beta; Belongs to the integrin beta chain family.	0.401
FBLN1	MFAP2	ENSMMUP00000003257	ENSMMUP00000076823	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.	ShKT domain-containing protein.	0.583
FBLN1	MYOC	ENSMMUP00000003257	ENSMMUP00000017941	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.	Myocilin.	0.515
IGFBP3	IGFBP5	ENSMMUP00000018098	ENSMMUP00000059646	Insulin-like growth factor-binding protein 3 isoform b.	Insulin-like growth factor-binding protein 5.	0.804
IGFBP3	IGFBP6	ENSMMUP00000018098	ENSMMUP00000070222	Insulin-like growth factor-binding protein 3 isoform b.	Insulin-like growth factor-binding protein 6.	0.493
IGFBP5	IGFBP3	ENSMMUP00000059646	ENSMMUP00000018098	Insulin-like growth factor-binding protein 5.	Insulin-like growth factor-binding protein 3 isoform b.	0.804
IGFBP5	IGFBP6	ENSMMUP00000059646	ENSMMUP00000070222	Insulin-like growth factor-binding protein 5.	Insulin-like growth factor-binding protein 6.	0.476
IGFBP6	IGFBP3	ENSMMUP00000070222	ENSMMUP00000018098	Insulin-like growth factor-binding protein 6.	Insulin-like growth factor-binding protein 3 isoform b.	0.493
IGFBP6	IGFBP5	ENSMMUP00000070222	ENSMMUP00000059646	Insulin-like growth factor-binding protein 6.	Insulin-like growth factor-binding protein 5.	0.476
ITGA3	ITGA4	ENSMMUP00000000216	ENSMMUP00000000407	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.809
ITGA3	ITGAV	ENSMMUP00000000216	ENSMMUP00000025579	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	0.719
ITGA3	ITGB3	ENSMMUP00000000216	ENSMMUP00000004380	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.853
ITGA3	THBS1	ENSMMUP00000000216	ENSMMUP00000007925	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Thrombospondin 1.	0.963