STRINGSTRING
SERPINB9 SERPINB9 ITGA3 ITGA3 SERPINC1 SERPINC1 SPATA2 SPATA2 TIMP4 TIMP4 COL1A1 COL1A1 SERPINF2 SERPINF2 FAP FAP ITGB3 ITGB3 STIM1 STIM1 CTSG CTSG FURIN FURIN TIMP2 TIMP2 ACR ACR BCL10 BCL10 TYSND1 TYSND1 COMP COMP DVL3 DVL3 SH3PXD2A SH3PXD2A BRCA2 BRCA2 XBP1 XBP1 LONP2 LONP2 BFAR BFAR DPP4 DPP4 PTEN PTEN TP53 TP53 TTN TTN CASP8AP2 CASP8AP2 CDK5R1 CDK5R1 ELANE ELANE MARCHF6 MARCHF6 CARD17 CARD17 SLC2A13 SLC2A13 CCBE1 CCBE1 CLTC CLTC MUC5B MUC5B CD70 CD70 POLG POLG ANXA2 ANXA2 PDZD3 PDZD3 FLOT2 FLOT2 PSAP PSAP FLOT1 FLOT1 MALT1 MALT1 RNF139 RNF139 CTLA4 CTLA4 TNFRSF10A TNFRSF10A BCL2L10 BCL2L10 SEMG2 SEMG2 SYVN1 SYVN1 ITGAV ITGAV AMFR AMFR VCP VCP ENSMMUP00000079229 ENSMMUP00000079229 PRKN PRKN SERPINA1 SERPINA1 YIPF5 YIPF5 CD177 CD177 CARD18 CARD18 NLRC4 NLRC4 A2ML1 A2ML1 SRI SRI ANXA9 ANXA9 NLRP7 NLRP7 RIPK2 RIPK2 BANK1 BANK1 LOC716527 LOC716527 ALPI ALPI ADAMTSL4 ADAMTSL4 TIMP1 TIMP1 TNFAIP3 TNFAIP3 MBP MBP SUMO1 SUMO1 COL3A1 COL3A1 SERPINB13 SERPINB13 SART3 SART3 DERL1 DERL1 UBB UBB LOC106994543 LOC106994543 CRADD CRADD BDKRB2 BDKRB2 LDLR LDLR PINK1 PINK1 BIN1 BIN1 VWF VWF RFFL RFFL NFRKB NFRKB RIOK3 RIOK3 ATP9A ATP9A TNF TNF PARK7 PARK7 RAD23A RAD23A ECM1 ECM1 GSK3B GSK3B OS9 OS9 COL1A2 COL1A2 KIT KIT CST3 CST3 FADD FADD LOC722294 LOC722294 CHL1 CHL1 FBXO45 FBXO45 LOC701315 LOC701315 PRNP PRNP ENSMMUP00000064504 ENSMMUP00000064504 FN1 FN1 FAM20C FAM20C CD28 CD28 LCOR LCOR PSAPL1 PSAPL1 TIMP3 TIMP3 SERPINE1 SERPINE1 MBP-A MBP-A BCL2 BCL2 BAG6 BAG6 NOL3 NOL3 TWNK TWNK F3 F3 PYCARD PYCARD NTRK2 NTRK2 ADAMTS4 ADAMTS4 TRIP4 TRIP4 IL1R1 IL1R1 SERPINA5 SERPINA5 TNFRSF10C TNFRSF10C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SERPINB9Serpin family B member 9; Belongs to the serpin family. (515 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
SERPINC1Antithrombin III; Belongs to the serpin family. (464 aa)
SPATA2Spermatogenesis-associated protein PD1. (520 aa)
TIMP4TIMP metallopeptidase inhibitor 4. (224 aa)
COL1A1Collagen alpha-1(I) chain preproprotein. (1464 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (594 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
STIM1Stromal interaction molecule 1. (684 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
TIMP2NTR domain-containing protein. (499 aa)
ACRAcrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (419 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
TYSND1Trypsin domain containing 1. (566 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (716 aa)
SH3PXD2ASH3 and PX domains 2A. (1105 aa)
BRCA2BRCA2 DNA repair associated. (3377 aa)
XBP1X-box binding protein 1. (376 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (853 aa)
BFARBifunctional apoptosis regulator. (450 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (766 aa)
PTENUncharacterized protein. (589 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
TTNTitin. (32000 aa)
CASP8AP2Caspase 8 associated protein 2. (2043 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (263 aa)
MARCHF6Membrane associated ring-CH-type finger 6. (952 aa)
CARD17Caspase recruitment domain family member 17. (110 aa)
SLC2A13Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (647 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
MUC5BMucin 5B, oligomeric mucus/gel-forming. (4928 aa)
CD70CD70 molecule; Belongs to the tumor necrosis factor family. (316 aa)
POLGDNA polymerase gamma, catalytic subunit. (1228 aa)
ANXA2Annexin. (357 aa)
PDZD3PDZ domain containing 3. (505 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (524 aa)
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (439 aa)
MALT1MALT1 paracaspase. (824 aa)
RNF139E3 ubiquitin-protein ligase RNF139. (664 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM. (223 aa)
TNFRSF10ATNF receptor superfamily member 10a. (471 aa)
BCL2L10Uncharacterized protein. (194 aa)
SEMG2Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa. (623 aa)
SYVN1E3 ubiquitin-protein ligase synoviolin isoform b. (617 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
AMFRAutocrine motility factor receptor. (643 aa)
VCPUncharacterized protein; Belongs to the AAA ATPase family. (823 aa)
ENSMMUP00000079229Uncharacterized protein. (756 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
SERPINA1SERPIN domain-containing protein; Belongs to the serpin family. (458 aa)
YIPF5Protein YIPF. (257 aa)
CD177CD177 molecule. (424 aa)
CARD18Caspase recruitment domain family member 18. (91 aa)
NLRC4NLR family CARD domain containing 4. (1024 aa)
A2ML1Alpha-2-macroglobulin like 1. (1454 aa)
SRISorcin isoform a. (198 aa)
ANXA9Annexin. (345 aa)
NLRP7Uncharacterized protein. (1009 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (797 aa)
LOC716527Flotillin-2. (428 aa)
ALPIAlkaline phosphatase. (528 aa)
ADAMTSL4ADAMTS like 4. (1100 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (790 aa)
MBPMyelin basic protein. (437 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1466 aa)
SERPINB13Serpin family B member 13; Belongs to the serpin family. (400 aa)
SART3Uncharacterized protein. (1009 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (280 aa)
UBBUncharacterized protein. (229 aa)
LOC106994543SERPIN domain-containing protein; Belongs to the serpin family. (390 aa)
CRADDDeath domain-containing protein CRADD. (199 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
LDLRUncharacterized protein. (918 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (581 aa)
BIN1Bridging integrator 1. (668 aa)
VWFUncharacterized protein. (2888 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (511 aa)
NFRKBNuclear factor related to kappaB binding protein. (1433 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
ATP9APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1120 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
PARK7Protein DJ-1. (189 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (363 aa)
ECM1Extracellular matrix protein 1 isoform 1. (540 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
OS9Protein OS-9 isoform 1. (668 aa)
COL1A2Collagen type I alpha 2 chain. (1274 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
CST3Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family. (146 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
LOC722294Uncharacterized protein. (1105 aa)
CHL1Cell adhesion molecule L1 like. (1225 aa)
FBXO45Uncharacterized protein. (286 aa)
LOC701315SERPIN domain-containing protein; Belongs to the serpin family. (390 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa)
ENSMMUP00000064504CARD domain-containing protein. (199 aa)
FN1Fibronectin isoform 1 preproprotein. (2477 aa)
FAM20CFam20C domain-containing protein. (584 aa)
CD28T-cell-specific surface glycoprotein CD28. (220 aa)
LCORUncharacterized protein. (1698 aa)
PSAPL1Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. (521 aa)
TIMP3Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15 (By similarity). (211 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (407 aa)
MBP-AC-type lectin domain-containing protein. (275 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
BAG6BCL2 associated athanogene 6. (1238 aa)
NOL3Nucleolar protein 3. (206 aa)
TWNKTwinkle protein, mitochondrial isoform A. (684 aa)
F3Tissue factor isoform 1. (296 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform a. (195 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
ADAMTS4A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein. (837 aa)
TRIP4Thyroid hormone receptor interactor 4. (581 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
SERPINA5SERPIN domain-containing protein; Belongs to the serpin family. (1039 aa)
TNFRSF10CUncharacterized protein. (184 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (34%) [HD]