STRINGSTRING
EDN2 EDN2 HCN4 HCN4 CALML5 CALML5 F6T365_MACMU F6T365_MACMU BVES BVES KCNH2 KCNH2 F7H9V3_MACMU F7H9V3_MACMU SPTBN4 SPTBN4 DSG2 DSG2 SRI SRI KCNA5 KCNA5 EDNRA EDNRA CACNA1G CACNA1G ANK2 ANK2 TRPV1 TRPV1 CTNNA3 CTNNA3 ADA ADA ATP2A2 ATP2A2 ENSMMUP00000044881 ENSMMUP00000044881 NOS1AP NOS1AP MYH7 MYH7 ADRB1 ADRB1 YWHAE YWHAE ADM5 ADM5 CACNA1D CACNA1D EDNRB EDNRB CACNA2D1 CACNA2D1 CAMK2D CAMK2D SREBF1 SREBF1 ENSMMUP00000053387 ENSMMUP00000053387 BIN1 BIN1 EPAS1 EPAS1 KCNH6 KCNH6 GCH1 GCH1 KCNE4 KCNE4 RYR2 RYR2 PKP2 PKP2 AVPR1A AVPR1A ADRA1A ADRA1A TRPM4 TRPM4 CAV3 CAV3 EDN1 EDN1 SCN1B SCN1B RNLS RNLS DRD2 DRD2 MDM2 MDM2 CAV1 CAV1 RANGRF RANGRF JUP JUP CACNA1C CACNA1C HCN2 HCN2 GJD3 GJD3 DMD DMD PDE4D PDE4D OXT OXT NPPA NPPA KCNQ1 KCNQ1 CACNB2 CACNB2 KCNJ3 KCNJ3 HEY2 HEY2 ISL1 ISL1 SHOX2 SHOX2 ADRA1D ADRA1D CASQ2 CASQ2 KCNJ5 KCNJ5 SCN2B SCN2B ADM ADM SCN4B SCN4B MC3R MC3R EDN3 EDN3 AKAP9 AKAP9 FKBP1B FKBP1B KCNE2 KCNE2 KCNE5 KCNE5 DSC2 DSC2 ADM2 ADM2 AGTR2 AGTR2 SPX SPX HRC HRC SLC1A1 SLC1A1 TACR3 TACR3 HCN3 HCN3 KCNE3 KCNE3 HCN1 HCN1 KCNJ2 KCNJ2 TMEM161B TMEM161B ADRA1B ADRA1B DSP DSP SLC8A1 SLC8A1 SCN5A SCN5A SCN10A SCN10A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDN2Endothelin 2. (206 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
CALML5Calmodulin-like protein 5. (146 aa)
F6T365_MACMU14_3_3 domain-containing protein. (74 aa)
BVESBlood vessel epicardial substance. (360 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1159 aa)
F7H9V3_MACMUUncharacterized protein. (584 aa)
SPTBN4Spectrin beta chain, brain 3 isoform sigma5. (678 aa)
DSG2Desmoglein 2. (1115 aa)
SRISorcin isoform a. (198 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
EDNRAUncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
ANK2Ankyrin 2. (4045 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (839 aa)
CTNNA3Catenin alpha-3. (895 aa)
ADAAdenosine deaminase. (390 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1011 aa)
ENSMMUP00000044881A_deaminase domain-containing protein. (74 aa)
NOS1APPID domain-containing protein. (695 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
ADRB1Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (478 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
ADM5Adrenomedullin 5 (putative). (154 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (527 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
CAMK2DProtein kinase domain-containing protein. (687 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
ENSMMUP00000053387Uncharacterized protein. (205 aa)
BIN1Bridging integrator 1. (668 aa)
EPAS1Endothelial PAS domain protein 1. (875 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (994 aa)
GCH1GTP cyclohydrolase 1. (250 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (170 aa)
RYR2Ryanodine receptor 2. (4967 aa)
PKP2Plakophilin 2. (790 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
ADRA1AAdrenoceptor alpha 1A. (445 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1215 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
EDN1Preproendothelin-1. (211 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (402 aa)
RNLSRenalase, FAD dependent amine oxidase. (342 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
CAV1Caveolin 1. (303 aa)
RANGRFUncharacterized protein. (186 aa)
JUPUncharacterized protein. (744 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (888 aa)
GJD3Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (293 aa)
DMDUncharacterized protein. (3685 aa)
PDE4DPhosphodiesterase. (809 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
NPPANatriuretic peptide A. (153 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
CACNB2SH3 domain-containing protein. (660 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1. (501 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
ISL1ISL LIM homeobox 1. (413 aa)
SHOX2Short stature homeobox 2. (355 aa)
ADRA1DAdrenoceptor alpha 1D. (570 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (446 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (469 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
ADMAdrenomedullin. (211 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (316 aa)
MC3RMelanocortin 3 receptor. (323 aa)
EDN3Endothelin 3. (257 aa)
AKAP9A-kinase anchoring protein 9. (4049 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
DSC2Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (947 aa)
ADM2Uncharacterized protein. (148 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (365 aa)
SPXSpexin hormone. (158 aa)
HRCHistidine rich calcium binding protein. (799 aa)
SLC1A1Excitatory amino acid transporter 3. (524 aa)
TACR3NK-3 receptor; Belongs to the G-protein coupled receptor 1 family. (463 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (777 aa)
KCNE3Uncharacterized protein. (103 aa)
HCN1Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1. (885 aa)
KCNJ2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] (427 aa)
TMEM161BTransmembrane protein 161B. (489 aa)
ADRA1BAdrenoceptor alpha 1B. (518 aa)
DSPDesmoplakin. (2871 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1956 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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