(24 nodes) Outflow tract septum morphogenesis network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	LRP2	LDL receptor related protein 2. (4660 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	ENG	Endoglin. (672 aa)
	GATA6	Transcription factor GATA-6. (595 aa)
	NKX2-5	NK2 homeobox 5. (324 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1177 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	ISL1	ISL LIM homeobox 1. (413 aa)
	ROBO2	Roundabout guidance receptor 2. (1394 aa)
	PARVA	Parvin alpha. (372 aa)
	TBX1	T-box transcription factor 1. (496 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	ROBO1	Roundabout guidance receptor 1. (1691 aa)
	SMAD6	Mothers against decapentaplegic homolog. (496 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (925 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	TBX20	T-box transcription factor TBX20. (447 aa)
	SEMA3C	Semaphorin-3C; Belongs to the semaphorin family. (751 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMPR1A	ENSMMUP00000077296	ENSMMUP00000079770	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.995
BMP4	BMPR2	ENSMMUP00000077296	ENSMMUP00000011799	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.992
BMP4	FGF8	ENSMMUP00000077296	ENSMMUP00000020713	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.698
BMP4	FGFR2	ENSMMUP00000077296	ENSMMUP00000048184	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.509
BMP4	GATA6	ENSMMUP00000077296	ENSMMUP00000073874	Bone morphogenetic protein 4.	Transcription factor GATA-6.	0.608
BMP4	ISL1	ENSMMUP00000077296	ENSMMUP00000063915	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.582
BMP4	LRP2	ENSMMUP00000077296	ENSMMUP00000077987	Bone morphogenetic protein 4.	LDL receptor related protein 2.	0.561
BMP4	NKX2-5	ENSMMUP00000077296	ENSMMUP00000072700	Bone morphogenetic protein 4.	NK2 homeobox 5.	0.545
BMP4	SMAD4	ENSMMUP00000077296	ENSMMUP00000024106	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.887
BMP4	SMAD6	ENSMMUP00000077296	ENSMMUP00000044372	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.664
BMP4	TGFBR2	ENSMMUP00000077296	ENSMMUP00000013111	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.529
BMPR1A	BMP4	ENSMMUP00000079770	ENSMMUP00000077296	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.995
BMPR1A	BMPR2	ENSMMUP00000079770	ENSMMUP00000011799	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.986
BMPR1A	ENG	ENSMMUP00000079770	ENSMMUP00000076624	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.441
BMPR1A	SMAD4	ENSMMUP00000079770	ENSMMUP00000024106	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.824
BMPR1A	SMAD6	ENSMMUP00000079770	ENSMMUP00000044372	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.773
BMPR1A	TGFB2	ENSMMUP00000079770	ENSMMUP00000064264	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.477
BMPR1A	TGFBR2	ENSMMUP00000079770	ENSMMUP00000013111	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.668
BMPR2	BMP4	ENSMMUP00000011799	ENSMMUP00000077296	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.992
BMPR2	BMPR1A	ENSMMUP00000011799	ENSMMUP00000079770	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.986