STRINGSTRING
NPY2R NPY2R SEMA3C SEMA3C FZD2 FZD2 TGFBR2 TGFBR2 BMPR2 BMPR2 NOG NOG FOXC1 FOXC1 DHRS3 DHRS3 PLXND1 PLXND1 RYR1 RYR1 FOXH1 FOXH1 GJA5 GJA5 TGFBR3 TGFBR3 NPY1R NPY1R BMPR1A BMPR1A TBX3 TBX3 LRP2 LRP2 BMP4 BMP4 ENG ENG JUN JUN FOXC2 FOXC2 WNT5A WNT5A GATA6 GATA6 ZFPM1 ZFPM1 NKX2-5 NKX2-5 ZFPM2 ZFPM2 HEYL HEYL SOX18 SOX18 PITX2 PITX2 SOX17 SOX17 TGFB2 TGFB2 ISL1 ISL1 HEY2 HEY2 WNT11 WNT11 EDN1 EDN1 DVL2 DVL2 ROBO2 ROBO2 HIF1A HIF1A SOX11 SOX11 PARVA PARVA ELN ELN EYA1 EYA1 TBX1 TBX1 TBX2 TBX2 CITED2 CITED2 ATF2 ATF2 FGFR2 FGFR2 ROBO1 ROBO1 SMAD6 SMAD6 CITED4 CITED4 MEF2C MEF2C NRP1 NRP1 EDNRA EDNRA HAND2 HAND2 SEC24B SEC24B NIPBL NIPBL NPY5R NPY5R NRP2 NRP2 SMAD4 SMAD4 JAG1 JAG1 NOTCH1 NOTCH1 CLDN5 CLDN5 SFRP2 SFRP2 FGF8 FGF8 TBX20 TBX20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NPY2RNeuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (381 aa)
SEMA3CSemaphorin-3C; Belongs to the semaphorin family. (751 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FOXC1Forkhead box C1. (551 aa)
DHRS3Short-chain dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
PLXND1Plexin D1. (1925 aa)
RYR1Ryanodine receptor 1. (4928 aa)
FOXH1Forkhead box H1. (352 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
NPY1RNeuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TBX3T-box transcription factor 3. (743 aa)
LRP2LDL receptor related protein 2. (4660 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ENGEndoglin. (672 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
FOXC2Forkhead box C2. (471 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
GATA6Transcription factor GATA-6. (595 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1024 aa)
NKX2-5NK2 homeobox 5. (324 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1177 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (477 aa)
SOX18SRY-box transcription factor 18. (384 aa)
PITX2Homeobox protein. (354 aa)
SOX17SRY-box transcription factor 17. (414 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ISL1ISL LIM homeobox 1. (413 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
EDN1Preproendothelin-1. (211 aa)
DVL2Dishevelled segment polarity protein 2. (767 aa)
ROBO2Roundabout guidance receptor 2. (1394 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
SOX11Transcription factor SOX. (441 aa)
PARVAParvin alpha. (372 aa)
ELNElastin. (796 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
TBX1T-box transcription factor 1. (496 aa)
TBX2T-box transcription factor 2. (712 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
ROBO1Roundabout guidance receptor 1. (1691 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
CITED4Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (232 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
EDNRAUncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HAND2BHLH domain-containing protein. (186 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1277 aa)
NIPBLNipped-B protein. (2804 aa)
NPY5RG_PROTEIN_RECEP_F1_2 domain-containing protein. (455 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (925 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NOTCH1Notch receptor 1. (2556 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TBX20T-box transcription factor TBX20. (447 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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