STRINGSTRING
PKP2 PKP2 PPP1R13L PPP1R13L RYR2 RYR2 HEG1 HEG1 TGFBR3 TGFBR3 FOXH1 FOXH1 COL11A1 COL11A1 FOXC1 FOXC1 NOG NOG MYL10 MYL10 GATA3 GATA3 TGFBR2 TGFBR2 MESP1 MESP1 HAND1 HAND1 CHD7 CHD7 SEMA3C SEMA3C TBX5 TBX5 TBX20 TBX20 TNNT2 TNNT2 NPY2R NPY2R SOX4 SOX4 MYL3 MYL3 DSP DSP BMP10 BMP10 MYBPC3 MYBPC3 SFRP2 SFRP2 NOTCH1 NOTCH1 PTCD2 PTCD2 JAG1 JAG1 SMAD4 SMAD4 GATA4 GATA4 NPY5R NPY5R GRHL2 GRHL2 TGFB1 TGFB1 HAND2 HAND2 EDNRA EDNRA POU4F1 POU4F1 MEF2C MEF2C TNNI1 TNNI1 MYH7 MYH7 FGFR2 FGFR2 TGFBR1 TGFBR1 HEY1 HEY1 SOX11 SOX11 HIF1A HIF1A MYL2 MYL2 MED1 MED1 HEY2 HEY2 FOXF1 FOXF1 SMAD7 SMAD7 ISL1 ISL1 TGFB2 TGFB2 NRG1 NRG1 DLL4 DLL4 PROX1 PROX1 SMARCD3 SMARCD3 HEYL HEYL ZFPM2 ZFPM2 NKX2-5 NKX2-5 FOXC2 FOXC2 TNNC1 TNNC1 ENG ENG LRP2 LRP2 BMPR1A BMPR1A CPE CPE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKP2Plakophilin 2. (790 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (828 aa)
RYR2Ryanodine receptor 2. (4967 aa)
HEG1Heart development protein with EGF like domains 1. (1486 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
FOXH1Forkhead box H1. (352 aa)
COL11A1Collagen alpha-1(XI) chain isoform A preproprotein. (1806 aa)
FOXC1Forkhead box C1. (551 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MYL10Myosin light chain 10. (226 aa)
GATA3GATA binding protein 3. (444 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7. (2998 aa)
SEMA3CSemaphorin-3C; Belongs to the semaphorin family. (751 aa)
TBX5T-box transcription factor 5. (518 aa)
TBX20T-box transcription factor TBX20. (447 aa)
TNNT2Troponin T2, cardiac type. (302 aa)
NPY2RNeuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (381 aa)
SOX4Transcription factor SOX. (467 aa)
MYL3Myosin light chain 3. (254 aa)
DSPDesmoplakin. (2871 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
MYBPC3Myosin binding protein C, cardiac. (1274 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
NOTCH1Notch receptor 1. (2556 aa)
PTCD2Pentatricopeptide repeat domain 2. (364 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GATA4GATA binding protein 4. (443 aa)
NPY5RG_PROTEIN_RECEP_F1_2 domain-containing protein. (455 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
HAND2BHLH domain-containing protein. (186 aa)
EDNRAUncharacterized protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
POU4F1POU domain protein. (423 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 1. (473 aa)
TNNI1Uncharacterized protein. (187 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform a. (304 aa)
SOX11Transcription factor SOX. (441 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
MYL2Myosin light chain 2. (166 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
FOXF1Forkhead box F1. (432 aa)
SMAD7Mothers against decapentaplegic homolog. (462 aa)
ISL1ISL LIM homeobox 1. (413 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NRG1Neuregulin 1. (700 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
PROX1Prospero homeobox protein 1. (737 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (533 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (477 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1177 aa)
NKX2-5NK2 homeobox 5. (324 aa)
FOXC2Forkhead box C2. (471 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (213 aa)
ENGEndoglin. (672 aa)
LRP2LDL receptor related protein 2. (4660 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CPECarboxypeptidase E preproprotein. (476 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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