STRINGSTRING
PRIMPOL PRIMPOL RFC5 RFC5 RAD51C RAD51C POLH POLH TP53 TP53 PIF1 PIF1 RPA2 RPA2 MUS81 MUS81 BLM BLM SMARCAL1 SMARCAL1 RAD18 RAD18 POLD3 POLD3 F7DM39_MACMU F7DM39_MACMU TIMELESS TIMELESS POLA2 POLA2 WRN WRN XRCC3 XRCC3 CHEK1 CHEK1 RTF2 RTF2 DMAP1 DMAP1 RPA1 RPA1 POLA1 POLA1 TREX1 TREX1 MMS22L MMS22L WDHD1 WDHD1 SMARCAD1 SMARCAD1 RFC1 RFC1 RAD51B RAD51B DNMT1 DNMT1 RADX RADX TP53BP1 TP53BP1 UHRF1 UHRF1 POLD1 POLD1 ENSMMUP00000069269 ENSMMUP00000069269 POLD2 POLD2 HMCES HMCES POLD4 POLD4 EME2 EME2 GPR83 GPR83 RFC2 RFC2 RFC4 RFC4 ATP5PO ATP5PO TIPIN TIPIN RFC3 RFC3 XRCC2 XRCC2 TONSL TONSL ZMIZ2 ZMIZ2 PRIM2 PRIM2 RPA3 RPA3 ZRANB3 ZRANB3 MCM10 MCM10 PCNA PCNA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRIMPOLPrimase and DNA directed polymerase. (593 aa)
RFC5Replication factor C subunit 5 isoform 1. (340 aa)
RAD51CRAD51 paralog C. (367 aa)
POLHDNA polymerase eta. (712 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (707 aa)
RPA2Uncharacterized protein. (270 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
BLMBLM RecQ like helicase. (1416 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (505 aa)
POLD3DNA polymerase delta subunit 3. (466 aa)
F7DM39_MACMUUncharacterized protein. (143 aa)
TIMELESSTimeless circadian regulator. (1204 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
WRNWRN RecQ like helicase. (1426 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa)
CHEK1STT3 oligosaccharyltransferase complex catalytic subunit A. (768 aa)
RTF2Replication termination factor 2. (338 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (612 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
POLA1DNA polymerase. (1465 aa)
TREX1Three prime repair exonuclease 1. (474 aa)
MMS22LMMS22 like, DNA repair protein. (1243 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1127 aa)
SMARCAD1annotation not available (1026 aa)
RFC1Replication factor C subunit 1. (1146 aa)
RAD51BRAD51 paralog B. (424 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1717 aa)
RADXUncharacterized protein. (855 aa)
TP53BP1Tumor protein p53 binding protein 1. (1977 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (795 aa)
POLD1DNA polymerase. (1145 aa)
ENSMMUP00000069269Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (437 aa)
POLD2DNA polymerase delta 2, accessory subunit. (536 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (360 aa)
POLD4DNA polymerase delta subunit p12. (107 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (379 aa)
GPR83Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (778 aa)
RFC2Replication factor C subunit 2. (233 aa)
RFC4Replication factor C subunit 4. (363 aa)
ATP5PODownstream neighbor of SON. (564 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (307 aa)
RFC3Replication factor C subunit 3 isoform 1. (356 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
TONSLTonsoku like, DNA repair protein. (1377 aa)
ZMIZ2Zinc finger MIZ domain-containing protein 2 isoform 1. (920 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1124 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (875 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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