31 items (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	F7DM39_MACMU	Uncharacterized protein. (143 aa)
	ENSMMUP00000080749	Uncharacterized protein. (117 aa)
	LIG1	DNA ligase. (1108 aa)
	ENSMMUP00000069269	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (437 aa)
	MLH3	Uncharacterized protein. (1505 aa)
	MUTYH	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (553 aa)
	RPA3	Replication protein A 14 kDa subunit. (121 aa)
	MSH4	MutS homolog 4. (935 aa)
	UPK3B	Uncharacterized protein. (276 aa)
	RNASEH2A	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa)
	H9H3U9_MACMU	Uncharacterized protein. (164 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	PMS1	PMS1 homolog 1, mismatch repair system component. (931 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (442 aa)
	RNASEH2B	Ribonuclease H2 subunit B. (353 aa)
	TREX1	Three prime repair exonuclease 1. (474 aa)
	MSH3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1124 aa)
	XPC	XPC complex subunit, DNA damage recognition and repair factor. (994 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	EXO1	Exonuclease 1. (846 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (938 aa)
	MSH5	DNA_MISMATCH_REPAIR_2 domain-containing protein. (834 aa)
	MCM9	Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
	MLH1	MutL homolog 1. (756 aa)
	TDG	Thymine DNA glycosylase. (410 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2565 aa)
	POLD3	DNA polymerase delta subunit 3. (466 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (660 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	TP73	ENSMMUP00000053665	ENSMMUP00000021769	Tyrosine-protein kinase.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.602
ENSMMUP00000069269	ERCC1	ENSMMUP00000069269	ENSMMUP00000051568	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.682
ENSMMUP00000069269	EXO1	ENSMMUP00000069269	ENSMMUP00000037489	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Exonuclease 1.	0.784
ENSMMUP00000069269	F7DM39_MACMU	ENSMMUP00000069269	ENSMMUP00000028100	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.880
ENSMMUP00000069269	LIG1	ENSMMUP00000069269	ENSMMUP00000069832	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA ligase.	0.649
ENSMMUP00000069269	MCM9	ENSMMUP00000069269	ENSMMUP00000033059	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family.	0.766
ENSMMUP00000069269	MLH1	ENSMMUP00000069269	ENSMMUP00000029670	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	MutL homolog 1.	0.589
ENSMMUP00000069269	MSH2	ENSMMUP00000069269	ENSMMUP00000036559	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.762
ENSMMUP00000069269	MSH3	ENSMMUP00000069269	ENSMMUP00000045732	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.594
ENSMMUP00000069269	MSH4	ENSMMUP00000069269	ENSMMUP00000001169	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	MutS homolog 4.	0.581
ENSMMUP00000069269	MSH5	ENSMMUP00000069269	ENSMMUP00000034068	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.551
ENSMMUP00000069269	MSH6	ENSMMUP00000069269	ENSMMUP00000030085	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.848
ENSMMUP00000069269	PCNA	ENSMMUP00000069269	ENSMMUP00000062455	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.874
ENSMMUP00000069269	PMS2	ENSMMUP00000069269	ENSMMUP00000035494	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	PMS1 homolog 2, mismatch repair system component.	0.506
ENSMMUP00000069269	POLD3	ENSMMUP00000069269	ENSMMUP00000027170	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase delta subunit 3.	0.419
ENSMMUP00000069269	RPA3	ENSMMUP00000069269	ENSMMUP00000001149	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Replication protein A 14 kDa subunit.	0.880
ENSMMUP00000069269	TP73	ENSMMUP00000069269	ENSMMUP00000021769	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.460
ENSMMUP00000069269	XPC	ENSMMUP00000069269	ENSMMUP00000043928	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	XPC complex subunit, DNA damage recognition and repair factor.	0.651
ENSMMUP00000080749	H9H3U9_MACMU	ENSMMUP00000080749	ENSMMUP00000021334	Uncharacterized protein.	Uncharacterized protein.	0.957
ENSMMUP00000080749	LIG1	ENSMMUP00000080749	ENSMMUP00000069832	Uncharacterized protein.	DNA ligase.	0.420