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MED25 MED25 TAF6 TAF6 MED30 MED30 STON1 STON1 MED11 MED11 ENSMMUP00000058345 ENSMMUP00000058345 PPARGC1A PPARGC1A MED29 MED29 GTF2F2 GTF2F2 POLR2G POLR2G TAF2 TAF2 LOC106994494 LOC106994494 TAF4B TAF4B GTF2A2 GTF2A2 CDK7 CDK7 F6XRN0_MACMU F6XRN0_MACMU TAF7L TAF7L GTF2A1 GTF2A1 MAZ MAZ MED24 MED24 F7HPQ9_MACMU F7HPQ9_MACMU F7HPQ7_MACMU F7HPQ7_MACMU GTF2E2 GTF2E2 POLR2I POLR2I GTF2E1 GTF2E1 MED27 MED27 POLR2D POLR2D MED19 MED19 MED21 MED21 TAF1 TAF1 LOC702124 LOC702124 TAF10 TAF10 TAF4 TAF4 MED16 MED16 MED18 MED18 MED7 MED7 TAF5 TAF5 E2F2 E2F2 TAF8 TAF8 MED23 MED23 MED9 MED9 ELOC ELOC MED4 MED4 LOC100426235 LOC100426235 TAF6L TAF6L MED31 MED31 GTF2B GTF2B TAF7 TAF7 ELOA ELOA CDK9 CDK9 TAF12 TAF12 TAF13 TAF13 ERCC3 ERCC3 GTF2H5 GTF2H5 MED26 MED26 TAF3 TAF3 MED15 MED15 F7GDN6_MACMU F7GDN6_MACMU TAF1L TAF1L MED14 MED14 ENSMMUP00000044764 ENSMMUP00000044764 TAF11 TAF11 MED8 MED8 ELOB ELOB E2F3 E2F3 TBP TBP CCNH CCNH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MED25Mediator complex subunit 25. (796 aa)
TAF6TATA-box binding protein associated factor 6. (678 aa)
MED30Mediator of RNA polymerase II transcription subunit 30. (178 aa)
STON1Stonin-1; May be involved in the endocytic machinery. (1182 aa)
MED11Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (206 aa)
ENSMMUP00000058345TAFII28 domain-containing protein. (199 aa)
PPARGC1APPARG coactivator 1 alpha. (818 aa)
MED29Mediator complex subunit 29. (200 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
POLR2GS1 domain-containing protein. (209 aa)
TAF2TATA-box binding protein associated factor 2. (1251 aa)
LOC106994494TFIIS N-terminal domain-containing protein. (529 aa)
TAF4BTATA-box binding protein associated factor 4b. (862 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
F6XRN0_MACMUUbiquitin-like domain-containing protein. (122 aa)
TAF7LTATA-box binding protein associated factor 7 like. (505 aa)
GTF2A1Transcription initiation factor IIA subunit 1 isoform 1. (376 aa)
MAZMYC associated zinc finger protein. (493 aa)
MED24Mediator of RNA polymerase II transcription subunit 24 isoform 1. (989 aa)
F7HPQ9_MACMUTAFII28 domain-containing protein. (199 aa)
F7HPQ7_MACMUTAFII28 domain-containing protein. (196 aa)
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (320 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
GTF2E1General transcription factor IIE subunit 1. (450 aa)
MED27Mediator of RNA polymerase II transcription subunit 27. (311 aa)
POLR2DDNA-directed RNA polymerase II subunit RPB4. (142 aa)
MED19Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (244 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (208 aa)
TAF1Transcription initiation factor TFIID subunit. (1895 aa)
LOC702124Uncharacterized protein. (950 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
TAF4TATA-box binding protein associated factor 4. (1083 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (877 aa)
MED18Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (208 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (232 aa)
TAF5TATA-box binding protein associated factor 5. (800 aa)
E2F2E2F transcription factor 2. (437 aa)
TAF8TATA-box binding protein associated factor 8. (367 aa)
MED23Mediator complex subunit 23. (1374 aa)
MED9Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (156 aa)
ELOCElongin C; Belongs to the SKP1 family. (151 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (362 aa)
LOC100426235Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (252 aa)
TAF6LTAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L. (622 aa)
MED31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
GTF2BGeneral transcription factor IIB. (312 aa)
TAF7Transcription initiation factor TFIID subunit 7. (349 aa)
ELOAElongin A. (846 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
TAF12TFIID_20kDa domain-containing protein. (214 aa)
TAF13Transcription initiation factor TFIID subunit 13. (124 aa)
ERCC3TFIIH basal transcription factor complex helicase XPB subunit. (782 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
MED26TFIIS N-terminal domain-containing protein. (615 aa)
TAF3TATA-box binding protein associated factor 3. (1008 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (788 aa)
F7GDN6_MACMUProtein kinase domain-containing protein. (165 aa)
TAF1LTATA-box binding protein associated factor 1 like. (1776 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1454 aa)
ENSMMUP00000044764TFIIA_gamma_C domain-containing protein. (74 aa)
TAF11Transcription initiation factor TFIID subunit 11. (211 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (378 aa)
ELOBTranscription elongation factor B polypeptide 2 isoform a. (118 aa)
E2F3E2F transcription factor 3. (465 aa)
TBPTATA-box binding protein. (326 aa)
CCNHCyclin H; Belongs to the cyclin family. (331 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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