STRINGSTRING
PRRT1 PRRT1 SYT4 SYT4 STXBP5 STXBP5 RABAC1 RABAC1 SLC17A8 SLC17A8 ROGDI ROGDI C20H16orf70 C20H16orf70 SLC9B2 SLC9B2 STX11 STX11 SYPL1 SYPL1 PICALM PICALM SV2C SV2C DDC DDC SLC18A1 SLC18A1 SLC17A6 SLC17A6 SLC6A17 SLC6A17 SYNGR2 SYNGR2 STON2 STON2 COPS4 COPS4 ATP6V0A1 ATP6V0A1 PTPRN2 PTPRN2 VAMP4 VAMP4 ATP2B1 ATP2B1 ABCC8 ABCC8 AMPH AMPH STX10 STX10 MT3 MT3 RAB40B RAB40B SNCAIP SNCAIP GABBR1 GABBR1 MCTP1 MCTP1 ATP6V1E1 ATP6V1E1 SYT8 SYT8 NCSTN NCSTN SLC2A8 SLC2A8 SYT1 SYT1 GRIN1 GRIN1 SEPTIN6 SEPTIN6 ATP6AP2 ATP6AP2 SYPL2 SYPL2 UNC13C UNC13C ATP6V1C1 ATP6V1C1 NTF3 NTF3 KIF1B KIF1B SYNGR1 SYNGR1 STX2 STX2 BRSK1 BRSK1 SV2A SV2A UNC13B UNC13B NGF NGF GRIN2A GRIN2A RPH3A RPH3A STX1A STX1A RAB15 RAB15 SYNGR3 SYNGR3 DGKI DGKI SNAP91 SNAP91 PPT1 PPT1 RAB40C RAB40C SYT5 SYT5 ATP6V1B2 ATP6V1B2 KIRREL3 KIRREL3 APBA2 APBA2 SLC18A2 SLC18A2 SCAMP1 SCAMP1 SYT7 SYT7 UNC13A UNC13A CBARP CBARP APBA1 APBA1 BIN1 BIN1 SYT11 SYT11 SLC30A3 SLC30A3 MCTP2 MCTP2 SYT6 SYT6 LOC703257 LOC703257 CLTA CLTA CLCN4 CLCN4 BDNF BDNF KCNK9 KCNK9 GRIA1 GRIA1 EGK_14116 EGK_14116 RAB35 RAB35 SEPTIN5 SEPTIN5 ICA1 ICA1 TPRG1L TPRG1L RAB27B RAB27B SNAP25 SNAP25 ATP6AP1 ATP6AP1 IQSEC1 IQSEC1 RAB3D-2 RAB3D-2 RAB40A RAB40A SYT2 SYT2 TMEM163 TMEM163 SYP SYP DOC2A DOC2A VAMP1 VAMP1 DLG4 DLG4 SYN1 SYN1 TMED9 TMED9 BORCS5 BORCS5 ATP6V1G2 ATP6V1G2 VTI1A VTI1A ZNRF1 ZNRF1 ENSMMUP00000072478 ENSMMUP00000072478 BTBD8 BTBD8 SLC17A5 SLC17A5 APH1A APH1A SNAPIN SNAPIN STX3 STX3 SVOP SVOP RAB26 RAB26 DTNBP1 DTNBP1 RAB12 RAB12 SYNPR SYNPR RAB13 RAB13 LOC114675552 LOC114675552 SYT12 SYT12 RAB8B RAB8B ENSMMUP00000078303 ENSMMUP00000078303 SNAP47 SNAP47 STX4 STX4 DNAJC5 DNAJC5 RAB40AL RAB40AL SYT9 SYT9 CLN3 CLN3 DMXL2 DMXL2 SYN2 SYN2 STX16 STX16 ATP6V1B1 ATP6V1B1 STX1B STX1B LAMP5 LAMP5 SLC32A1 SLC32A1 SLC40A1 SLC40A1 GABRA2 GABRA2 TOR1A TOR1A TH TH RAB3C RAB3C LOC114677611 LOC114677611 GIPC1 GIPC1 BCL2L1 BCL2L1 COPS5 COPS5 HCRT HCRT SLC4A8 SLC4A8 MME MME SYN3 SYN3 PENK PENK PDE4B PDE4B SEMA4C SEMA4C BACE1 BACE1 SV2B SV2B RNF112 RNF112 CLTB CLTB PRRT2 PRRT2 LAMP1 LAMP1 MARCKSL1 MARCKSL1 SEPTIN8 SEPTIN8 TRIM9 TRIM9 PTPRS PTPRS GAD2 GAD2 DMD DMD CPLX3 CPLX3 LGI3 LGI3 SYNGR4 SYNGR4 DISC1 DISC1 MFF MFF TMEM230 TMEM230 WFS1 WFS1 DNM1L DNM1L VPS45 VPS45 CDK16 CDK16 RAB3B RAB3B OTOF OTOF APP APP BSN BSN SLC17A7 SLC17A7 SLC6A9 SLC6A9 NTF4 NTF4 LRRK2 LRRK2 VTI1B VTI1B TRAPPC4 TRAPPC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRRT1Uncharacterized protein. (346 aa)
SYT4Synaptotagmin IV. (425 aa)
STXBP5Syntaxin binding protein 5. (1152 aa)
RABAC1PRA1 family protein. (185 aa)
SLC17A8Solute carrier family 17 member 8. (589 aa)
ROGDIRogdi atypical leucine zipper. (287 aa)
C20H16orf70Chromosome 20 C16orf70 homolog. (422 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
STX11Syntaxin 11; Belongs to the syntaxin family. (313 aa)
SYPL1Synaptophysin-like protein 1 isoform a. (259 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (674 aa)
SV2CSynaptic vesicle glycoprotein 2C. (727 aa)
DDCAromatic-L-amino-acid decarboxylase. (480 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
SLC17A6Solute carrier family 17 member 6. (582 aa)
SLC6A17Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (727 aa)
SYNGR2Synaptogyrin. (224 aa)
STON2Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (955 aa)
COPS4COP9 signalosome subunit 4. (420 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
PTPRN2Receptor-type tyrosine-protein phosphatase N2 isoform 1. (1015 aa)
VAMP4Vesicle-associated membrane protein 4 isoform 1. (141 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
ABCC8ATP binding cassette subfamily C member 8. (1581 aa)
AMPHAmphiphysin isoform 1. (694 aa)
STX10Syntaxin 10; Belongs to the syntaxin family. (324 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
RAB40BRAB40B, member RAS oncogene family. (276 aa)
SNCAIPSynuclein alpha interacting protein. (1017 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (962 aa)
MCTP1Multiple C2 and transmembrane domain containing 1. (998 aa)
ATP6V1E1V-type proton ATPase subunit E 1 isoform a. (226 aa)
SYT8Synaptotagmin 8. (476 aa)
NCSTNNicastrin. (720 aa)
SLC2A8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (516 aa)
SYT1Synaptotagmin 1. (422 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
SEPTIN6Septin 6; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (445 aa)
ATP6AP2Renin/prorenin receptor. (350 aa)
SYPL2Synaptophysin like 2. (270 aa)
UNC13CUnc-13 homolog C. (2216 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
KIF1BKinesin family member 1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1829 aa)
SYNGR1Synaptogyrin 1. (431 aa)
STX2Syntaxin-2 isoform 2; Belongs to the syntaxin family. (288 aa)
BRSK1Serine/threonine-protein kinase BRSK1. (778 aa)
SV2ASynaptic vesicle glycoprotein 2A. (742 aa)
UNC13BUnc-13 homolog B. (1971 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
RPH3ARabphilin 3A. (694 aa)
STX1ASyntaxin-1A isoform 1; Belongs to the syntaxin family. (288 aa)
RAB15RAB15, member RAS oncogene family. (225 aa)
SYNGR3Synaptogyrin. (229 aa)
DGKIDiacylglycerol kinase. (1100 aa)
SNAP91Synaptosome associated protein 91. (908 aa)
PPT1Uncharacterized protein. (304 aa)
RAB40CRas-related protein Rab-40C isoform a. (281 aa)
SYT5Synaptotagmin 5. (386 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (507 aa)
KIRREL3Kirre like nephrin family adhesion molecule 3. (778 aa)
APBA2Amyloid beta A4 protein-binding family A member 2 isoform a. (749 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
SCAMP1Secretory carrier-associated membrane protein. (338 aa)
SYT7Synaptotagmin 7. (708 aa)
UNC13AUnc-13 homolog A. (1677 aa)
CBARPCACN subunit beta associated regulatory protein. (752 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (838 aa)
BIN1Bridging integrator 1. (668 aa)
SYT11Synaptotagmin-11. (431 aa)
SLC30A3Solute carrier family 30 member 3. (388 aa)
MCTP2Multiple C2 and transmembrane domain-containing protein 2. (877 aa)
SYT6Synaptotagmin 6. (633 aa)
LOC703257ENTH domain-containing protein. (344 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
CLCN4Chloride channel protein. (760 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
KCNK9Potassium two pore domain channel subfamily K member 9; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (501 aa)
GRIA1Uncharacterized protein. (916 aa)
EGK_14116V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (147 aa)
RAB35Uncharacterized protein. (266 aa)
SEPTIN5Septin 5; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (442 aa)
ICA1AH domain-containing protein. (513 aa)
TPRG1LTumor protein p63-regulated gene 1-like protein. (272 aa)
RAB27BRAB27B, member RAS oncogene family. (218 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Belongs to the SNAP-25 family. (206 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (470 aa)
IQSEC1SEC7 domain-containing protein. (1225 aa)
RAB3D-2Ras-related protein Rab-3D. (219 aa)
RAB40ARAB40A, member RAS oncogene family. (278 aa)
SYT2Synaptotagmin 2. (470 aa)
TMEM163Transmembrane protein 163. (289 aa)
SYPSynaptophysin. (401 aa)
DOC2ADouble C2 domain alpha. (498 aa)
VAMP1Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Belongs to the synaptobrevin family. (118 aa)
DLG4Uncharacterized protein; Belongs to the MAGUK family. (972 aa)
SYN1Synapsin-1 isoform Ia. (705 aa)
TMED9Transmembrane emp24 domain-containing protein 9. (235 aa)
BORCS5Loss of heterozygosity 12 chromosomal region 1 protein. (196 aa)
ATP6V1G2V-type proton ATPase subunit G 2; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
VTI1At-SNARE coiled-coil homology domain-containing protein. (228 aa)
ZNRF1E3 ubiquitin-protein ligase ZNRF1. (227 aa)
ENSMMUP00000072478Uncharacterized protein. (103 aa)
BTBD8BTB domain containing 8. (1964 aa)
SLC17A5Solute carrier family 17 member 5. (495 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (274 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (338 aa)
SVOPSV2 related protein. (562 aa)
RAB26RAB26, member RAS oncogene family. (254 aa)
DTNBP1Dystrobrevin binding protein 1. (425 aa)
RAB12RAB12, member RAS oncogene family. (404 aa)
SYNPRSynaptoporin isoform 1. (285 aa)
RAB13Uncharacterized protein. (245 aa)
LOC114675552SOCS box domain-containing protein. (269 aa)
SYT12Synaptotagmin 12. (436 aa)
RAB8BRAB8B, member RAS oncogene family. (286 aa)
ENSMMUP00000078303V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
SNAP47Synaptosome associated protein 47. (453 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (322 aa)
DNAJC5DnaJ homolog subfamily C member 5. (198 aa)
RAB40ALSOCS box domain-containing protein. (279 aa)
SYT9Synaptotagmin-9. (491 aa)
CLN3Battenin. (438 aa)
DMXL2Dmx like 2. (3058 aa)
SYN2Synapsin II. (584 aa)
STX16Syntaxin-16 isoform a; Belongs to the syntaxin family. (325 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (289 aa)
LAMP5Lysosomal associated membrane protein family member 5. (280 aa)
SLC32A1Vesicular inhibitory amino acid transporter. (525 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (631 aa)
GABRA2Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (511 aa)
TOR1ATorsin family 1 member A. (532 aa)
THTyrosine hydroxylase. (501 aa)
RAB3CUncharacterized protein. (231 aa)
LOC114677611V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
GIPC1PDZ domain-containing protein GIPC1 isoform 1. (333 aa)
BCL2L1Bcl-2-like protein 1 isoform 1. (233 aa)
COPS5COP9 signalosome complex subunit 5. (334 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
SLC4A8Anion exchange protein. (1093 aa)
MMEMembrane metalloendopeptidase. (750 aa)
SYN3Synapsin III. (580 aa)
PENKProenkephalin. (300 aa)
PDE4BPhosphodiesterase. (736 aa)
SEMA4CUncharacterized protein; Belongs to the semaphorin family. (833 aa)
BACE1Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family. (501 aa)
SV2BMFS domain-containing protein. (699 aa)
RNF112RING finger protein 112. (631 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
PRRT2Proline-rich transmembrane protein 2 isoform 1. (340 aa)
LAMP1Lysosomal associated membrane protein 1. (733 aa)
MARCKSL1MARCKS-related protein. (195 aa)
SEPTIN8Septin 8; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (483 aa)
TRIM9Tripartite motif containing 9. (776 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
GAD2Glutamate decarboxylase 2. (608 aa)
DMDUncharacterized protein. (3685 aa)
CPLX3Complexin III. (158 aa)
LGI3Leucine-rich repeat LGI family member 3. (548 aa)
SYNGR4Synaptogyrin. (234 aa)
DISC1Uncharacterized protein. (885 aa)
MFFMitochondrial fission factor. (352 aa)
TMEM230Transmembrane protein 230. (183 aa)
WFS1Wolframin ER transmembrane glycoprotein. (890 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa)
VPS45Vacuolar protein sorting-associated protein 45; Belongs to the STXBP/unc-18/SEC1 family. (570 aa)
CDK16Cyclin dependent kinase 16. (570 aa)
RAB3BRAB3B, member RAS oncogene family. (219 aa)
OTOFOtoferlin. (1996 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa)
BSNBassoon presynaptic cytomatrix protein. (3722 aa)
SLC17A7Solute carrier family 17 member 7. (560 aa)
SLC6A9Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (706 aa)
NTF4NGF domain-containing protein; Belongs to the NGF-beta family. (210 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
VTI1Bt-SNARE coiled-coil homology domain-containing protein. (392 aa)
TRAPPC4Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (219 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (18%) [HD]