STRINGSTRING
UPF1 UPF1 MLH1 MLH1 ATRX ATRX WRN WRN MSH6 MSH6 XRCC3 XRCC3 MCM9 MCM9 CHD8 CHD8 RAD51 RAD51 MSH5 MSH5 RAD17 RAD17 PMS2 PMS2 MSH2 MSH2 MCM5 MCM5 MCM8 MCM8 C14H11orf80 C14H11orf80 F7GDN6_MACMU F7GDN6_MACMU RUVBL1 RUVBL1 HFM1 HFM1 ENSMMUP00000081106 ENSMMUP00000081106 CHD5 CHD5 ENSMMUP00000080145 ENSMMUP00000080145 ENSMMUP00000079882 ENSMMUP00000079882 ENSMMUP00000079501 ENSMMUP00000079501 ENSMMUP00000078304 ENSMMUP00000078304 ENSMMUP00000078219 ENSMMUP00000078219 ENSMMUP00000078171 ENSMMUP00000078171 ENSMMUP00000078038 ENSMMUP00000078038 ENSMMUP00000077980 ENSMMUP00000077980 F7BA84_MACMU F7BA84_MACMU XRCC6 XRCC6 MCM4 MCM4 ENSMMUP00000077154 ENSMMUP00000077154 ENSMMUP00000077052 ENSMMUP00000077052 ENSMMUP00000076692 ENSMMUP00000076692 ENSMMUP00000076476 ENSMMUP00000076476 FBH1 FBH1 SUPV3L1 SUPV3L1 ENSMMUP00000076112 ENSMMUP00000076112 ENSMMUP00000076057 ENSMMUP00000076057 MPHOSPH9 MPHOSPH9 ENSMMUP00000075071 ENSMMUP00000075071 ENSMMUP00000074958 ENSMMUP00000074958 ENSMMUP00000074599 ENSMMUP00000074599 ERCC6L2 ERCC6L2 ENSMMUP00000074077 ENSMMUP00000074077 ENSMMUP00000073829 ENSMMUP00000073829 ENSMMUP00000073692 ENSMMUP00000073692 ENSMMUP00000073439 ENSMMUP00000073439 RECQL5 RECQL5 ENSMMUP00000073228 ENSMMUP00000073228 CEP41 CEP41 ENSMMUP00000072605 ENSMMUP00000072605 TWNK TWNK ENSMMUP00000072325 ENSMMUP00000072325 MYO18A MYO18A ENSMMUP00000071800 ENSMMUP00000071800 ENSMMUP00000071582 ENSMMUP00000071582 ENSMMUP00000071404 ENSMMUP00000071404 ENSMMUP00000071396 ENSMMUP00000071396 ENSMMUP00000071385 ENSMMUP00000071385 ENSMMUP00000071221 ENSMMUP00000071221 ENSMMUP00000071090 ENSMMUP00000071090 ENSMMUP00000070931 ENSMMUP00000070931 INO80 INO80 ENSMMUP00000070419 ENSMMUP00000070419 ENSMMUP00000070211 ENSMMUP00000070211 SMC6 SMC6 ENSMMUP00000070153 ENSMMUP00000070153 IGHMBP2 IGHMBP2 ENSMMUP00000068930 ENSMMUP00000068930 ENSMMUP00000068906 ENSMMUP00000068906 ENSMMUP00000068896 ENSMMUP00000068896 ENSMMUP00000068854 ENSMMUP00000068854 RUVBL2 RUVBL2 ENSMMUP00000068691 ENSMMUP00000068691 C1H1orf61 C1H1orf61 ENSMMUP00000068556 ENSMMUP00000068556 ENSMMUP00000068266 ENSMMUP00000068266 ENSMMUP00000068094 ENSMMUP00000068094 ENSMMUP00000067988 ENSMMUP00000067988 ENSMMUP00000067410 ENSMMUP00000067410 ENSMMUP00000067379 ENSMMUP00000067379 ENSMMUP00000067154 ENSMMUP00000067154 ENSMMUP00000066584 ENSMMUP00000066584 ENSMMUP00000066356 ENSMMUP00000066356 ENSMMUP00000066109 ENSMMUP00000066109 ERCC3 ERCC3 ENSMMUP00000065390 ENSMMUP00000065390 ENSMMUP00000065065 ENSMMUP00000065065 ENSMMUP00000065002 ENSMMUP00000065002 ENSMMUP00000064914 ENSMMUP00000064914 ENSMMUP00000064776 ENSMMUP00000064776 ENSMMUP00000064710 ENSMMUP00000064710 MLH3 MLH3 ENSMMUP00000064684 ENSMMUP00000064684 ENSMMUP00000064519 ENSMMUP00000064519 ENSMMUP00000064501 ENSMMUP00000064501 ENSMMUP00000064134 ENSMMUP00000064134 ENSMMUP00000063917 ENSMMUP00000063917 ENSMMUP00000063409 ENSMMUP00000063409 DNA2 DNA2 ENSMMUP00000061748 ENSMMUP00000061748 ENSMMUP00000061662 ENSMMUP00000061662 ENSMMUP00000061459 ENSMMUP00000061459 ENSMMUP00000061449 ENSMMUP00000061449 ZRANB3 ZRANB3 CHD3 CHD3 RFC1 RFC1 ENSMMUP00000057031 ENSMMUP00000057031 DDX1 DDX1 SMARCAD1 SMARCAD1 KNL1 KNL1 PMS1 PMS1 POLQ POLQ ATAD5 ATAD5 SETX SETX ERCC2 ERCC2 MSH3 MSH3 BTAF1 BTAF1 RAD54L2 RAD54L2 MCM3 MCM3 DDX11 DDX11 MCM2 MCM2 RTEL1 RTEL1 SPO11 SPO11 F6YRS3_MACMU F6YRS3_MACMU SMARCA5 SMARCA5 MSH4 MSH4 XRCC5 XRCC5 DQX1 DQX1 XRCC2 XRCC2 RFC3 RFC3 HLTF HLTF DHX9 DHX9 KIAA1257 KIAA1257 PIF1 PIF1 CECR2 CECR2 WRNIP1 WRNIP1 TOP2B TOP2B SMARCA1 SMARCA1 TOP2A TOP2A BRIP1 BRIP1 CHD1L CHD1L RAD51C RAD51C SRCAP SRCAP RECQL RECQL DHX36 DHX36 RAD54L RAD54L CHD7 CHD7 CHD2 CHD2 SHPRH SHPRH SMARCA4 SMARCA4 GTF2F2 GTF2F2 ERCC6L ERCC6L MCM7 MCM7 F7GUC5_MACMU F7GUC5_MACMU CHD1 CHD1 G3BP1 G3BP1 SMARCA2 SMARCA2 HELQ HELQ RAD51B RAD51B CHD9 CHD9 FANCM FANCM C16H17orf64 C16H17orf64 HELB HELB TTF2 TTF2 NAV2 NAV2 HELLS HELLS TM4SF19 TM4SF19 RSF1 RSF1 MCM6 MCM6 EP400 EP400 ERCC6 ERCC6 CDK7 CDK7 CHD4 CHD4 BLM BLM SMARCAL1 SMARCAL1 CHD6 CHD6 ASCC3 ASCC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UPF1UPF1 RNA helicase and ATPase. (1129 aa)
MLH1MutL homolog 1. (756 aa)
ATRXATRX chromatin remodeler. (2490 aa)
WRNWRN RecQ like helicase. (1426 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2581 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (380 aa)
MSH5DNA_MISMATCH_REPAIR_2 domain-containing protein. (834 aa)
RAD17RAD17 checkpoint clamp loader component. (681 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (938 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (1009 aa)
C14H11orf80Uncharacterized protein. (311 aa)
F7GDN6_MACMUProtein kinase domain-containing protein. (165 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
HFM1Helicase for meiosis 1. (1434 aa)
ENSMMUP00000081106Uncharacterized protein. (102 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1997 aa)
ENSMMUP00000080145Uncharacterized protein. (408 aa)
ENSMMUP00000079882Uncharacterized protein. (145 aa)
ENSMMUP00000079501Uncharacterized protein. (118 aa)
ENSMMUP00000078304Uncharacterized protein. (180 aa)
ENSMMUP00000078219Uncharacterized protein. (113 aa)
ENSMMUP00000078171Uncharacterized protein. (75 aa)
ENSMMUP00000078038Uncharacterized protein. (157 aa)
ENSMMUP00000077980Uncharacterized protein. (88 aa)
F7BA84_MACMUUncharacterized protein. (140 aa)
XRCC6X-ray repair cross-complementing protein 6. (609 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
ENSMMUP00000077154Uncharacterized protein. (110 aa)
ENSMMUP00000077052Uncharacterized protein. (105 aa)
ENSMMUP00000076692Uncharacterized protein. (109 aa)
ENSMMUP00000076476Uncharacterized protein. (112 aa)
FBH1F-box DNA helicase 1. (1088 aa)
SUPV3L1ATP-dependent RNA helicase SUPV3L1, mitochondrial. (787 aa)
ENSMMUP00000076112Uncharacterized protein. (145 aa)
ENSMMUP00000076057Uncharacterized protein. (114 aa)
MPHOSPH9M-phase phosphoprotein 9. (1197 aa)
ENSMMUP00000075071Uncharacterized protein. (108 aa)
ENSMMUP00000074958Uncharacterized protein. (100 aa)
ENSMMUP00000074599Uncharacterized protein. (183 aa)
ERCC6L2Uncharacterized protein. (1551 aa)
ENSMMUP00000074077Uncharacterized protein. (137 aa)
ENSMMUP00000073829Uncharacterized protein. (75 aa)
ENSMMUP00000073692Uncharacterized protein. (112 aa)
ENSMMUP00000073439Uncharacterized protein. (102 aa)
RECQL5RecQ like helicase 5. (1027 aa)
ENSMMUP00000073228Uncharacterized protein. (153 aa)
CEP41Rhodanese domain-containing protein. (403 aa)
ENSMMUP00000072605Uncharacterized protein. (135 aa)
TWNKTwinkle protein, mitochondrial isoform A. (684 aa)
ENSMMUP00000072325Uncharacterized protein. (131 aa)
MYO18AMyosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2439 aa)
ENSMMUP00000071800Uncharacterized protein. (103 aa)
ENSMMUP00000071582Uncharacterized protein. (123 aa)
ENSMMUP00000071404Uncharacterized protein. (124 aa)
ENSMMUP00000071396Uncharacterized protein. (91 aa)
ENSMMUP00000071385Uncharacterized protein. (82 aa)
ENSMMUP00000071221Uncharacterized protein. (132 aa)
ENSMMUP00000071090Uncharacterized protein. (102 aa)
ENSMMUP00000070931Uncharacterized protein. (110 aa)
INO80Putative DNA helicase INO80 complex-like protein 1. (1556 aa)
ENSMMUP00000070419Uncharacterized protein. (175 aa)
ENSMMUP00000070211Uncharacterized protein. (156 aa)
SMC6Structural maintenance of chromosomes 6. (1092 aa)
ENSMMUP00000070153Uncharacterized protein. (115 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (991 aa)
ENSMMUP00000068930Uncharacterized protein. (161 aa)
ENSMMUP00000068906Uncharacterized protein. (100 aa)
ENSMMUP00000068896Uncharacterized protein. (157 aa)
ENSMMUP00000068854Uncharacterized protein. (120 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (497 aa)
ENSMMUP00000068691Uncharacterized protein. (123 aa)
C1H1orf61Uncharacterized protein. (190 aa)
ENSMMUP00000068556Uncharacterized protein. (113 aa)
ENSMMUP00000068266Uncharacterized protein. (84 aa)
ENSMMUP00000068094Uncharacterized protein. (156 aa)
ENSMMUP00000067988Uncharacterized protein. (125 aa)
ENSMMUP00000067410Uncharacterized protein. (102 aa)
ENSMMUP00000067379Uncharacterized protein. (115 aa)
ENSMMUP00000067154Uncharacterized protein. (126 aa)
ENSMMUP00000066584Uncharacterized protein. (142 aa)
ENSMMUP00000066356Uncharacterized protein. (147 aa)
ENSMMUP00000066109Uncharacterized protein. (110 aa)
ERCC3TFIIH basal transcription factor complex helicase XPB subunit. (782 aa)
ENSMMUP00000065390Uncharacterized protein. (212 aa)
ENSMMUP00000065065Uncharacterized protein. (130 aa)
ENSMMUP00000065002Uncharacterized protein. (311 aa)
ENSMMUP00000064914Uncharacterized protein. (117 aa)
ENSMMUP00000064776Uncharacterized protein. (112 aa)
ENSMMUP00000064710Uncharacterized protein. (157 aa)
MLH3Uncharacterized protein. (1505 aa)
ENSMMUP00000064684Uncharacterized protein. (64 aa)
ENSMMUP00000064519Uncharacterized protein. (122 aa)
ENSMMUP00000064501Uncharacterized protein. (111 aa)
ENSMMUP00000064134Uncharacterized protein. (152 aa)
ENSMMUP00000063917Uncharacterized protein. (155 aa)
ENSMMUP00000063409Uncharacterized protein. (167 aa)
DNA2DNA replication helicase/nuclease 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (1316 aa)
ENSMMUP00000061748Uncharacterized protein. (123 aa)
ENSMMUP00000061662Uncharacterized protein. (120 aa)
ENSMMUP00000061459Uncharacterized protein. (103 aa)
ENSMMUP00000061449Uncharacterized protein. (102 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1124 aa)
CHD3Uncharacterized protein. (2059 aa)
RFC1Replication factor C subunit 1. (1146 aa)
ENSMMUP00000057031Uncharacterized protein. (114 aa)
DDX1ATP-dependent RNA helicase DDX1. (740 aa)
SMARCAD1annotation not available (1026 aa)
KNL1Kinetochore scaffold 1. (2316 aa)
PMS1PMS1 homolog 1, mismatch repair system component. (931 aa)
POLQDNA polymerase theta. (2638 aa)
ATAD5ATPase family AAA domain containing 5. (1848 aa)
SETXSenataxin. (2721 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit isoform 1. (760 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1124 aa)
BTAF1B-TFIID TATA-box binding protein associated factor 1. (1858 aa)
RAD54L2Uncharacterized protein. (1611 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
DDX11DEAD/H-box helicase 11. (970 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1297 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (396 aa)
F6YRS3_MACMUKu domain-containing protein. (326 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
MSH4MutS homolog 4. (935 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
DQX1DEAQ-box RNA dependent ATPase 1. (740 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
RFC3Replication factor C subunit 3 isoform 1. (356 aa)
HLTFHelicase like transcription factor. (1010 aa)
DHX9ATP-dependent RNA helicase A. (1275 aa)
KIAA1257DUF4550 domain-containing protein. (1104 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (707 aa)
CECR2CECR2 histone acetyl-lysine reader. (1463 aa)
WRNIP1WRN helicase interacting protein 1. (665 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1621 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1070 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1189 aa)
CHD1LChromodomain-helicase-DNA-binding protein 1-like. (900 aa)
RAD51CRAD51 paralog C. (367 aa)
SRCAPHelicase SRCAP. (3229 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (656 aa)
DHX36DEAH-box helicase 36. (1008 aa)
RAD54LRAD54 like. (747 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7. (2998 aa)
CHD2Chromodomain-helicase-DNA-binding protein 2 isoform 1. (1828 aa)
SHPRHE3 ubiquitin-protein ligase SHPRH isoform a. (1683 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
ERCC6LERCC excision repair 6 like, spindle assembly checkpoint helicase. (1252 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
F7GUC5_MACMUUncharacterized protein. (217 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1716 aa)
G3BP1G3BP stress granule assembly factor 1. (546 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1586 aa)
HELQHelicase, POLQ like. (1101 aa)
RAD51BRAD51 paralog B. (424 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2902 aa)
FANCMFA complementation group M. (2050 aa)
C16H17orf64Chromosome 16 C17orf64 homolog. (236 aa)
HELBDNA helicase B. (1087 aa)
TTF2Transcription termination factor 2. (1170 aa)
NAV2Neuron navigator 2. (2452 aa)
HELLSUncharacterized protein. (883 aa)
TM4SF19Uncharacterized protein. (209 aa)
RSF1Remodeling and spacing factor 1. (1441 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
EP400E1A binding protein p400. (3045 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (2061 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
CHD4Chromodomain helicase DNA binding protein 4. (1912 aa)
BLMBLM RecQ like helicase. (1416 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2716 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3 isoform a. (2202 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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