38 items (Macaca mulatta) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	HIF1A	Hypoxia-inducible factor 1-alpha isoform 1. (826 aa)
	TAFA2	TAFA chemokine like family member 2. (142 aa)
	PPP1R1B	Uncharacterized protein. (433 aa)
	CHRNB2	Neuronal acetylcholine receptor subunit beta-2. (502 aa)
	NPTN	Neuroplastin isoform c. (394 aa)
	TTC36	Tetratricopeptide repeat domain 36. (189 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1081 aa)
	TANC1	Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1. (2023 aa)
	ZZEF1	Zinc finger ZZ-type and EF-hand domain containing 1. (3037 aa)
	LRRN4	Leucine rich repeat neuronal 4. (737 aa)
	CTNS	Cystinosin, lysosomal cystine transporter. (528 aa)
	NPS	Neuropeptide S. (89 aa)
	HRH1	Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (489 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
	MEIS2	Meis homeobox 2. (477 aa)
	NDRG4	NDRG family member 4. (494 aa)
	FOXB1	Forkhead box B1. (325 aa)
	KRAS	KRAS proto-oncogene, GTPase. (412 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	NF1	Neurofibromin 1. (2867 aa)
	DDHD2	Phospholipase DDHD2 isoform 1. (711 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	APP	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (751 aa)
	B4GALT2	Beta-1,4-galactosyltransferase 2. (382 aa)
	ABCA7	ATP binding cassette subfamily A member 7. (2111 aa)
	DBH	Dopamine beta-hydroxylase. (620 aa)
	IFT20	Intraflagellar transport protein 20-like protein. (158 aa)
	SLC7A11	Uncharacterized protein. (519 aa)
	CDK5	Cyclin dependent kinase 5. (364 aa)
	NETO1	Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1. (533 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1581 aa)
	RGS14	Regulator of G protein signaling 14. (566 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
	SYNGAP1	Synaptic Ras GTPase activating protein 1. (1303 aa)
	PDE1B	Phosphodiesterase. (538 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (763 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA7	APP	ENSMMUP00000020070	ENSMMUP00000018894	ATP binding cassette subfamily A member 7.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.532
APP	ABCA7	ENSMMUP00000018894	ENSMMUP00000020070	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	ATP binding cassette subfamily A member 7.	0.532
APP	CDK5	ENSMMUP00000018894	ENSMMUP00000026930	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Cyclin dependent kinase 5.	0.706
APP	GRIN1	ENSMMUP00000018894	ENSMMUP00000040251	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Glutamate ionotropic receptor NMDA type subunit 1.	0.540
APP	GRIN2A	ENSMMUP00000018894	ENSMMUP00000046309	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Glutamate ionotropic receptor NMDA type subunit 2A.	0.413
APP	MECP2	ENSMMUP00000018894	ENSMMUP00000055953	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.416
APP	NF1	ENSMMUP00000018894	ENSMMUP00000008965	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Neurofibromin 1.	0.444
BRAF	KRAS	ENSMMUP00000044832	ENSMMUP00000002635	B-Raf proto-oncogene, serine/threonine kinase.	KRAS proto-oncogene, GTPase.	0.995
BRAF	NF1	ENSMMUP00000044832	ENSMMUP00000008965	B-Raf proto-oncogene, serine/threonine kinase.	Neurofibromin 1.	0.720
CDK5	APP	ENSMMUP00000026930	ENSMMUP00000018894	Cyclin dependent kinase 5.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.706
CDK5	GRIN2A	ENSMMUP00000026930	ENSMMUP00000046309	Cyclin dependent kinase 5.	Glutamate ionotropic receptor NMDA type subunit 2A.	0.411
CDK5	PPP1R1B	ENSMMUP00000026930	ENSMMUP00000081131	Cyclin dependent kinase 5.	Uncharacterized protein.	0.977
CHRNB2	DRD2	ENSMMUP00000080762	ENSMMUP00000018833	Neuronal acetylcholine receptor subunit beta-2.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.456
CHRNB2	MECP2	ENSMMUP00000080762	ENSMMUP00000055953	Neuronal acetylcholine receptor subunit beta-2.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.627
DBH	DRD2	ENSMMUP00000022635	ENSMMUP00000018833	Dopamine beta-hydroxylase.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.589
DRD2	CHRNB2	ENSMMUP00000018833	ENSMMUP00000080762	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Neuronal acetylcholine receptor subunit beta-2.	0.456
DRD2	DBH	ENSMMUP00000018833	ENSMMUP00000022635	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Dopamine beta-hydroxylase.	0.589
DRD2	GRIN1	ENSMMUP00000018833	ENSMMUP00000040251	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Glutamate ionotropic receptor NMDA type subunit 1.	0.498
DRD2	GRIN2A	ENSMMUP00000018833	ENSMMUP00000046309	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Glutamate ionotropic receptor NMDA type subunit 2A.	0.515
DRD2	PPP1R1B	ENSMMUP00000018833	ENSMMUP00000081131	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.627