(16 nodes) Specification of animal organ identity network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ISL1	ISL LIM homeobox 1. (413 aa)
	FOXH1	Forkhead box H1. (352 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	PAX2	Paired box 2. (418 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (272 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform 1. (473 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (533 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (462 aa)
	AXIN2	Axin 2. (862 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	LRP2	LDL receptor related protein 2. (4660 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	BMP4	ENSMMUP00000076172	ENSMMUP00000077296	Axin 2.	Bone morphogenetic protein 4.	0.459
AXIN2	GLI3	ENSMMUP00000076172	ENSMMUP00000067447	Axin 2.	GLI family zinc finger 3.	0.475
AXIN2	LRP2	ENSMMUP00000076172	ENSMMUP00000077987	Axin 2.	LDL receptor related protein 2.	0.516
AXIN2	WNT11	ENSMMUP00000076172	ENSMMUP00000062663	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.584
AXIN2	WNT5A	ENSMMUP00000076172	ENSMMUP00000074193	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.701
BMP4	AXIN2	ENSMMUP00000077296	ENSMMUP00000076172	Bone morphogenetic protein 4.	Axin 2.	0.459
BMP4	FGF10	ENSMMUP00000077296	ENSMMUP00000053581	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.709
BMP4	FGFR2	ENSMMUP00000077296	ENSMMUP00000048184	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.509
BMP4	ISL1	ENSMMUP00000077296	ENSMMUP00000063915	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.582
BMP4	LRP2	ENSMMUP00000077296	ENSMMUP00000077987	Bone morphogenetic protein 4.	LDL receptor related protein 2.	0.561
BMP4	PAX2	ENSMMUP00000077296	ENSMMUP00000012018	Bone morphogenetic protein 4.	Paired box 2.	0.400
BMP4	WNT5A	ENSMMUP00000077296	ENSMMUP00000074193	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.510
FGF10	BMP4	ENSMMUP00000053581	ENSMMUP00000077296	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.709
FGF10	FGFR2	ENSMMUP00000053581	ENSMMUP00000048184	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.999
FGF10	ISL1	ENSMMUP00000053581	ENSMMUP00000063915	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	ISL LIM homeobox 1.	0.434
FGFR2	BMP4	ENSMMUP00000048184	ENSMMUP00000077296	Fibroblast growth factor receptor.	Bone morphogenetic protein 4.	0.509
FGFR2	FGF10	ENSMMUP00000048184	ENSMMUP00000053581	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.999
FOXH1	TBR1	ENSMMUP00000003588	ENSMMUP00000015629	Forkhead box H1.	T-box brain transcription factor 1.	0.440
GLI3	AXIN2	ENSMMUP00000067447	ENSMMUP00000076172	GLI family zinc finger 3.	Axin 2.	0.475
ISL1	BMP4	ENSMMUP00000063915	ENSMMUP00000077296	ISL LIM homeobox 1.	Bone morphogenetic protein 4.	0.582