(52 nodes) Negative regulation of cell-substrate adhesion network (Macaca mulatta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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Your Input:
	MAP4K4	Mitogen-activated protein kinase kinase kinase kinase 4 isoform 5. (1326 aa)
	MEN1	Menin isoform 2. (610 aa)
	ACVRL1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (597 aa)
	BCAS3	BCAS3 microtubule associated cell migration factor. (950 aa)
	RHOA	Ras homolog family member A. (209 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (775 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	DUSP22	Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (279 aa)
	TBCD	Tubulin folding cofactor D. (1257 aa)
	CLASP2	Uncharacterized protein. (1522 aa)
	CORO1C	Coronin; Belongs to the WD repeat coronin family. (527 aa)
	APOD	Apolipoprotein D. (189 aa)
	AP1AR	AP-1 complex-associated regulatory protein isoform a. (302 aa)
	PHLDB2	Pleckstrin homology like domain family B member 2. (1340 aa)
	PLET1	Placenta expressed transcript 1. (225 aa)
	COL1A1	Collagen alpha-1(I) chain preproprotein. (1464 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (407 aa)
	AJAP1	Adherens junction-associated protein 1. (410 aa)
	CX3CL1	C-X3-C motif chemokine ligand 1. (407 aa)
	RCC2	Regulator of chromosome condensation 2. (608 aa)
	GCNT2	Glucosaminyl (N-acetyl) transferase 2 (I blood group). (409 aa)
	SPOCK1	Uncharacterized protein. (457 aa)
	LOC114675624	Uncharacterized protein; Belongs to the MAGUK family. (450 aa)
	KANK1	ANK_REP_REGION domain-containing protein. (1364 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (279 aa)
	BCL6	Uncharacterized protein. (735 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (703 aa)
	RASA1	RAS p21 protein activator 1. (1044 aa)
	ARHGAP6	Rho GTPase activating protein 6. (977 aa)
	FZD4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	MMP12	Matrix metallopeptidase 12. (470 aa)
	DMTN	Dematin actin binding protein. (382 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	CORO2B	Coronin; Belongs to the WD repeat coronin family. (480 aa)
	NF1	Neurofibromin 1. (2867 aa)
	PTEN	Uncharacterized protein. (589 aa)
	ANGPT2	Angiopoietin 2. (496 aa)
	NEXMIF	Neurite extension and migration factor. (1515 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	MYOC	Myocilin. (491 aa)
	SPRY4	Sprouty RTK signaling antagonist 4. (299 aa)
	DLC1	DLC1 Rho GTPase activating protein. (1528 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	MELTF	Melanotransferrin. (817 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	PTPRO	Uncharacterized protein. (1216 aa)
	ADAM15	ADAM metallopeptidase domain 15. (919 aa)
	SRC	Tyrosine-protein kinase. (644 aa)
	EFNA5	EPH-related receptor tyrosine kinase ligand 7; Belongs to the ephrin family. (228 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACER2	APOD	ENSMMUP00000055061	ENSMMUP00000062473	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Apolipoprotein D.	0.506
ADAM15	SRC	ENSMMUP00000030724	ENSMMUP00000026506	ADAM metallopeptidase domain 15.	Tyrosine-protein kinase.	0.483
ANGPT2	THBS1	ENSMMUP00000013262	ENSMMUP00000007925	Angiopoietin 2.	Thrombospondin 1.	0.423
APOD	ACER2	ENSMMUP00000062473	ENSMMUP00000055061	Apolipoprotein D.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.506
ARHGAP6	RHOA	ENSMMUP00000005194	ENSMMUP00000045801	Rho GTPase activating protein 6.	Ras homolog family member A.	0.644
CASK	LOC114675624	ENSMMUP00000052036	ENSMMUP00000078523	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Uncharacterized protein; Belongs to the MAGUK family.	0.751
CASK	MELTF	ENSMMUP00000052036	ENSMMUP00000021787	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Melanotransferrin.	0.468
CLASP2	PHLDB2	ENSMMUP00000059650	ENSMMUP00000065480	Uncharacterized protein.	Pleckstrin homology like domain family B member 2.	0.520
COL1A1	FBLN1	ENSMMUP00000001955	ENSMMUP00000003257	Collagen alpha-1(I) chain preproprotein.	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.	0.596
COL1A1	MMP12	ENSMMUP00000001955	ENSMMUP00000005673	Collagen alpha-1(I) chain preproprotein.	Matrix metallopeptidase 12.	0.430
COL1A1	SERPINE1	ENSMMUP00000001955	ENSMMUP00000067352	Collagen alpha-1(I) chain preproprotein.	Serpin family E member 1; Belongs to the serpin family.	0.429
COL1A1	THBS1	ENSMMUP00000001955	ENSMMUP00000007925	Collagen alpha-1(I) chain preproprotein.	Thrombospondin 1.	0.554
CORO1C	RCC2	ENSMMUP00000061783	ENSMMUP00000073870	Coronin; Belongs to the WD repeat coronin family.	Regulator of chromosome condensation 2.	0.436
DLC1	RASA1	ENSMMUP00000019851	ENSMMUP00000004328	DLC1 Rho GTPase activating protein.	RAS p21 protein activator 1.	0.826
DLC1	RHOA	ENSMMUP00000019851	ENSMMUP00000045801	DLC1 Rho GTPase activating protein.	Ras homolog family member A.	0.651
EFNA5	PTPRO	ENSMMUP00000024191	ENSMMUP00000026885	EPH-related receptor tyrosine kinase ligand 7; Belongs to the ephrin family.	Uncharacterized protein.	0.653
EFNA5	RASA1	ENSMMUP00000024191	ENSMMUP00000004328	EPH-related receptor tyrosine kinase ligand 7; Belongs to the ephrin family.	RAS p21 protein activator 1.	0.924
FBLN1	COL1A1	ENSMMUP00000003257	ENSMMUP00000001955	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.	Collagen alpha-1(I) chain preproprotein.	0.596
FBLN1	MYOC	ENSMMUP00000003257	ENSMMUP00000017941	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.	Myocilin.	0.515
FZD4	FZD7	ENSMMUP00000005406	ENSMMUP00000041518	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	0.416