STRINGSTRING
STAT2 STAT2 VPS13C VPS13C ATP13A2 ATP13A2 TFRC TFRC IGF1 IGF1 PLA2G6 PLA2G6 TSC2 TSC2 SREBF2 SREBF2 BAX BAX MAPK8 MAPK8 MIEF1 MIEF1 MARCHF5 MARCHF5 USP36 USP36 CHCHD10 CHCHD10 BCL2L1 BCL2L1 BID BID TSPO TSPO HUWE1 HUWE1 FBXO7 FBXO7 CASP6 CASP6 TP53 TP53 PRELID1 PRELID1 ZNF205 ZNF205 OPA1 OPA1 TMEM135 TMEM135 HAX1 HAX1 AMBRA1 AMBRA1 KDR KDR GPX1 GPX1 MFF MFF PLD6 PLD6 DNM1L DNM1L PARL PARL DDHD2 DDHD2 BMF BMF GZMB GZMB PGAM5 PGAM5 LRRK2 LRRK2 CSNK2A2 CSNK2A2 VAT1 VAT1 HDAC6 HDAC6 MMP9 MMP9 INF2 INF2 DCN DCN BCL2L11 BCL2L11 GHITM GHITM HGF HGF ATP5IF1 ATP5IF1 TNFSF10 TNFSF10 MCU MCU PRKN PRKN VPS13D VPS13D BNIP3 BNIP3 OMA1 OMA1 BNIP3L BNIP3L TREM2 TREM2 MGARP MGARP RHOT1 RHOT1 STOX1 STOX1 AURKA AURKA HIP1R HIP1R LMNA LMNA IAPP IAPP PSMD10 PSMD10 MAPK10 MAPK10 LOC713693 LOC713693 MIEF2 MIEF2 FBXW7 FBXW7 MTCH2 MTCH2 GCLC GCLC FZD9 FZD9 MOAP1 MOAP1 SLC35F6 SLC35F6 GPER1 GPER1 BBC3 BBC3 GOLPH3 GOLPH3 SREBF1 SREBF1 ENSMMUP00000052599 ENSMMUP00000052599 PINK1 PINK1 FXN FXN USP30 USP30 RAP1GDS1 RAP1GDS1 HIF1A HIF1A ADCK1 ADCK1 PARK7 PARK7 CTTN CTTN CIDEB CIDEB ZDHHC6 ZDHHC6 PPARGC1A PPARGC1A GSK3B GSK3B ACAA2 ACAA2 SIRT7 SIRT7 AKT1 AKT1 TMEM14A TMEM14A PPIF PPIF SLC25A6 SLC25A6 PID1 PID1 BOK BOK LOC114675515 LOC114675515 MYO19 MYO19 ENSMMUP00000066266 ENSMMUP00000066266 FAM49B FAM49B BAK1 BAK1 BAD BAD RALA RALA RHOT2 RHOT2 PISD PISD SLC25A4 SLC25A4 CLU CLU MUL1 MUL1 CAMKK2 CAMKK2 SSBP1 SSBP1 BIK BIK CCND2 CCND2 NOL3 NOL3 FIS1 FIS1 AVP AVP SPIRE1 SPIRE1 LOC106994967 LOC106994967 ENSMMUP00000073035 ENSMMUP00000073035 HTRA2 HTRA2 PYCARD PYCARD HTT HTT RALBP1 RALBP1 FBXW9 FBXW9 LOC114674310 LOC114674310 MYLK3 MYLK3 RNF41 RNF41 SIVA1 SIVA1 FLCN FLCN EP300 EP300 STOML2 STOML2 TMEM102 TMEM102 VDAC1 VDAC1 PRMT6 PRMT6 TRIAP1 TRIAP1 FZD5 FZD5 FAM162A FAM162A DDHD1 DDHD1 PLSCR3 PLSCR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT2Signal transducer and activator of transcription. (851 aa)
VPS13CVacuolar protein sorting 13 homolog C. (3711 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1249 aa)
TFRCTransferrin receptor protein 1. (760 aa)
IGF1Insulin like growth factor 1. (208 aa)
PLA2G6Phospholipase A2 group VI. (935 aa)
TSC2TSC complex subunit 2. (2057 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1210 aa)
BAXUncharacterized protein. (279 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MIEF1Mitochondrial elongation factor 1. (478 aa)
MARCHF5Membrane associated ring-CH-type finger 5. (278 aa)
USP36Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1124 aa)
CHCHD10Coiled-coil-helix-coiled-coil-helix domain containing 10. (142 aa)
BCL2L1Bcl-2-like protein 1 isoform 1. (233 aa)
BIDBH3 interacting domain death agonist. (310 aa)
TSPOTranslocator protein isoform PBR. (169 aa)
HUWE1E3 ubiquitin-protein ligase HUWE1. (4374 aa)
FBXO7F-box only protein 7 isoform 1. (522 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
PRELID1PRELI domain-containing protein 1, mitochondrial. (219 aa)
ZNF205Zinc finger protein 205. (555 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1071 aa)
TMEM135Transmembrane protein 135. (502 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1238 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
MFFMitochondrial fission factor. (352 aa)
PLD6Phospholipase D family member 6. (270 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa)
PARLRhomboid domain-containing protein. (408 aa)
DDHD2Phospholipase DDHD2 isoform 1. (711 aa)
BMFBcl2 modifying factor. (196 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (315 aa)
PGAM5Serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1. (289 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (350 aa)
VAT1Vesicle amine transport protein 1. (401 aa)
HDAC6UBP-type domain-containing protein. (1257 aa)
MMP9Uncharacterized protein. (707 aa)
INF2Inverted formin, FH2 and WH2 domain containing. (1229 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
BCL2L11Uncharacterized protein. (292 aa)
GHITMGrowth hormone-inducible transmembrane protein; Belongs to the BI1 family. (345 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
ATP5IF1ATPase inhibitor, mitochondrial isoform 1. (106 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
MCUMitochondrial calcium uniporter. (351 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4387 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (194 aa)
OMA1OMA1 zinc metallopeptidase. (555 aa)
BNIP3LBCL2 interacting protein 3 like. (223 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (291 aa)
MGARPMitochondria localized glutamic acid rich protein. (240 aa)
RHOT1Ras homolog family member T1. (752 aa)
STOX1Storkhead box 1. (1119 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
HIP1RHuntingtin interacting protein 1 related. (1068 aa)
LMNAPrelamin-A/C isoform 1; Belongs to the intermediate filament family. (663 aa)
IAPPIslet amyloid polypeptide. (89 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (253 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC713693Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (223 aa)
MIEF2Mitochondrial elongation factor 2. (465 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform 1. (707 aa)
MTCH2Mitochondrial carrier homolog 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (303 aa)
GCLCGlutamate--cysteine ligase catalytic subunit isoform a. (637 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
MOAP1Modulator of apoptosis 1. (351 aa)
SLC35F6Solute carrier family 35 member F6; May play a role as a nucleotide-sugar transporter. (425 aa)
GPER1G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor that binds to 17-beta- estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine [...] (375 aa)
BBC3BCL2 binding component 3. (261 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
ENSMMUP00000052599Uncharacterized protein. (106 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (581 aa)
FXNFrataxin, mitochondrial isoform 1 preproprotein. (210 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (517 aa)
RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1 isoform 3. (607 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
ADCK1AarF domain containing kinase 1. (528 aa)
PARK7Protein DJ-1. (189 aa)
CTTNSH3 domain-containing protein. (566 aa)
CIDEBUncharacterized protein. (219 aa)
ZDHHC6Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (413 aa)
PPARGC1APPARG coactivator 1 alpha. (818 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
ACAA23-ketoacyl-CoA thiolase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
SIRT7Sirtuin 7. (421 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TMEM14AUncharacterized protein. (213 aa)
PPIFPeptidylprolyl isomerase F. (309 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (399 aa)
PID1PTB-containing, cubilin and LRP1-interacting protein isoform 2. (217 aa)
BOKBcl-2-related ovarian killer protein. (212 aa)
LOC114675515Uncharacterized protein. (152 aa)
MYO19Myosin XIX; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (982 aa)
ENSMMUP00000066266Uncharacterized protein. (188 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
BAK1Uncharacterized protein. (261 aa)
BADBcl2 antagonist of cell death. (167 aa)
RALARas-related protein Ral-A. (206 aa)
RHOT2Ras homolog family member T2. (680 aa)
PISDPhosphatidylserine decarboxylase. (463 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (342 aa)
CLUClusterin; Belongs to the clusterin family. (489 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (666 aa)
SSBP1Uncharacterized protein. (163 aa)
BIKBCL2 interacting killer. (160 aa)
CCND2Uncharacterized protein. (353 aa)
NOL3Nucleolar protein 3. (206 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (148 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
SPIRE1Spire type actin nucleation factor 1. (815 aa)
LOC106994967Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (196 aa)
ENSMMUP00000073035Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (245 aa)
HTRA2Serine protease HTRA2, mitochondrial isoform 1 preproprotein. (458 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform a. (195 aa)
HTTHuntingtin. (3170 aa)
RALBP1RalA binding protein 1. (655 aa)
FBXW9F-box and WD repeat domain containing 9. (502 aa)
LOC114674310BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (194 aa)
MYLK3VPS35 retromer complex component. (1442 aa)
RNF41E3 ubiquitin-protein ligase NRDP1 isoform 1. (317 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (680 aa)
EP300Histone acetyltransferase p300. (2414 aa)
STOML2Stomatin-like protein 2. (356 aa)
TMEM102Transmembrane protein 102. (508 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
PRMT6Protein arginine N-methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
TRIAP1TP53-regulated inhibitor of apoptosis 1. (76 aa)
FZD5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
FAM162AFamily with sequence similarity 162 member A. (155 aa)
DDHD1DDHD domain containing 1. (940 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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