(43 nodes) Regulation of keratinocyte proliferation network (Macaca mulatta)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	IFT74	Intraflagellar transport protein 74 homolog isoform a. (600 aa)
	IFT52	Intraflagellar transport protein 52 homolog. (437 aa)
	AREG	Amphiregulin. (252 aa)
	YAP1	Yes associated protein 1. (508 aa)
	VDR	Vitamin D receptor. (477 aa)
	IFT57	Intraflagellar transport 57. (439 aa)
	CRNN	Cornulin. (494 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	TGM1	Transglutaminase 1. (818 aa)
	OVOL1	Uncharacterized protein. (267 aa)
	SFN	14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
	INTU	Inturned planar cell polarity protein. (942 aa)
	SNAI2	Protein snail-like protein 2. (268 aa)
	IFT80	Intraflagellar transport protein 80 homolog isoform a. (777 aa)
	CD109	CD109 molecule. (1364 aa)
	SLURP1	Secreted LY6/PLAUR domain containing 1. (103 aa)
	IRF6	Interferon regulatory factor 6 isoform 1. (467 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
	LRG1	Leucine rich alpha-2-glycoprotein 1. (383 aa)
	CDH3	Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
	EFNB2	Ephrin B2; Belongs to the ephrin family. (333 aa)
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (894 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1126 aa)
	SRSF6	Serine and arginine rich splicing factor 6. (343 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	HAS2	Hyaluronan synthase 2. (552 aa)
	ZFP36	ZFP36 ring finger protein. (332 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (344 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	IFT172	Intraflagellar transport protein 172 homolog. (1749 aa)
	PTCH1	Patched 1. (1452 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	STXBP4	Syntaxin-binding protein 4. (554 aa)
	MDK	Midkine. (143 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
	KDF1	Keratinocyte differentiation factor 1. (398 aa)
	PTPRK	Protein tyrosine phosphatase receptor type K. (1485 aa)
	REG3A	Regenerating family member 3 alpha. (175 aa)
	REG3G	Regenerating family member 3 gamma. (174 aa)
	OVOL2	Transcription factor Ovo-like 2. (275 aa)
	LOC114675624	Uncharacterized protein; Belongs to the MAGUK family. (450 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREG	FGF7	ENSMMUP00000003091	ENSMMUP00000012883	Amphiregulin.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.429
AREG	FGFR2	ENSMMUP00000003091	ENSMMUP00000048184	Amphiregulin.	Fibroblast growth factor receptor.	0.714
AREG	HAS2	ENSMMUP00000003091	ENSMMUP00000042483	Amphiregulin.	Hyaluronan synthase 2.	0.582
CASK	LOC114675624	ENSMMUP00000052036	ENSMMUP00000078523	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Uncharacterized protein; Belongs to the MAGUK family.	0.751
CASK	STXBP4	ENSMMUP00000052036	ENSMMUP00000055856	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Syntaxin-binding protein 4.	0.509
CDH3	ZEB1	ENSMMUP00000032349	ENSMMUP00000036050	Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins.	Zinc finger E-box binding homeobox 1.	0.440
FGF10	FGF7	ENSMMUP00000053581	ENSMMUP00000012883	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.431
FGF10	FGFR2	ENSMMUP00000053581	ENSMMUP00000048184	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.999
FGF7	AREG	ENSMMUP00000012883	ENSMMUP00000003091	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Amphiregulin.	0.429
FGF7	FGF10	ENSMMUP00000012883	ENSMMUP00000053581	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.431
FGF7	FGFR2	ENSMMUP00000012883	ENSMMUP00000048184	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.996
FGF7	MDK	ENSMMUP00000012883	ENSMMUP00000059508	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Midkine.	0.418
FGFR2	AREG	ENSMMUP00000048184	ENSMMUP00000003091	Fibroblast growth factor receptor.	Amphiregulin.	0.714
FGFR2	FGF10	ENSMMUP00000048184	ENSMMUP00000053581	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.999
FGFR2	FGF7	ENSMMUP00000048184	ENSMMUP00000012883	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.996
HAS2	AREG	ENSMMUP00000042483	ENSMMUP00000003091	Hyaluronan synthase 2.	Amphiregulin.	0.582
IFT172	IFT52	ENSMMUP00000050974	ENSMMUP00000000531	Intraflagellar transport protein 172 homolog.	Intraflagellar transport protein 52 homolog.	0.995
IFT172	IFT57	ENSMMUP00000050974	ENSMMUP00000011515	Intraflagellar transport protein 172 homolog.	Intraflagellar transport 57.	0.997
IFT172	IFT74	ENSMMUP00000050974	ENSMMUP00000080693	Intraflagellar transport protein 172 homolog.	Intraflagellar transport protein 74 homolog isoform a.	0.975
IFT172	IFT80	ENSMMUP00000050974	ENSMMUP00000022739	Intraflagellar transport protein 172 homolog.	Intraflagellar transport protein 80 homolog isoform a.	0.994