(40 nodes) Regulation of cholesterol efflux network (Macaca mulatta)

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	ABCG1	ATP binding cassette subfamily G member 1. (696 aa)
	TTC39B	Tetratricopeptide repeat domain 39B. (682 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (274 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (317 aa)
	LRP1	LDL receptor related protein 1. (4561 aa)
	GPS2	G protein pathway suppressor 2. (327 aa)
	PTCH1	Patched 1. (1452 aa)
	ABCA8	ATP binding cassette subfamily A member 8. (1621 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
	RXRA	Retinoid X receptor alpha. (620 aa)
	NAXE	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (307 aa)
	TTC39A	Tetratricopeptide repeat domain 39A. (612 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (453 aa)
	ANAPC15	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (253 aa)
	F6ZRF7_MACMU	Uncharacterized protein. (573 aa)
	SIRT1	Sirtuin 1. (743 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (291 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (461 aa)
	ABCA2	ATP-binding cassette sub-family A member 2 isoform a. (2435 aa)
	ZDHHC8	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (778 aa)
	ABCA3	ATP binding cassette subfamily A member 3. (1704 aa)
	ABCA5	ATP binding cassette subfamily A member 5. (1642 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (500 aa)
	ABCA15	Uncharacterized protein. (182 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (267 aa)
	ABCA7	ATP binding cassette subfamily A member 7. (2111 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2595 aa)
	CAV1	Caveolin 1. (303 aa)
	YJEFN3	YjeF N-terminal domain containing 3. (299 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
	PLTP	Phospholipid transfer protein. (516 aa)
	CES1	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (611 aa)
	PON1	Paraoxonase 1. (355 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1210 aa)
	EEPD1	Endonuclease/exonuclease/phosphatase family domain containing 1. (569 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	PLA2G10	Phospholipase A(2). (165 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (646 aa)
	ENSMMUP00000079873	ABC transporter domain-containing protein. (155 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2266 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	ABCA15	ENSMMUP00000061741	ENSMMUP00000022037	ATP binding cassette subfamily A member 1.	Uncharacterized protein.	0.438
ABCA1	ABCG1	ENSMMUP00000061741	ENSMMUP00000059199	ATP binding cassette subfamily A member 1.	ATP binding cassette subfamily G member 1.	0.526
ABCA1	APOA1	ENSMMUP00000061741	ENSMMUP00000021209	ATP binding cassette subfamily A member 1.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.998
ABCA1	APOE	ENSMMUP00000061741	ENSMMUP00000048554	ATP binding cassette subfamily A member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.934
ABCA1	CAV1	ENSMMUP00000061741	ENSMMUP00000018556	ATP binding cassette subfamily A member 1.	Caveolin 1.	0.490
ABCA1	CETP	ENSMMUP00000061741	ENSMMUP00000023122	ATP binding cassette subfamily A member 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.818
ABCA1	NR1H2	ENSMMUP00000061741	ENSMMUP00000030833	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 2.	0.865
ABCA1	NR1H3	ENSMMUP00000061741	ENSMMUP00000037144	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 3.	0.883
ABCA1	PLTP	ENSMMUP00000061741	ENSMMUP00000013033	ATP binding cassette subfamily A member 1.	Phospholipid transfer protein.	0.701
ABCA1	PON1	ENSMMUP00000061741	ENSMMUP00000010502	ATP binding cassette subfamily A member 1.	Paraoxonase 1.	0.465
ABCA1	RXRA	ENSMMUP00000061741	ENSMMUP00000047169	ATP binding cassette subfamily A member 1.	Retinoid X receptor alpha.	0.694
ABCA1	SIRT1	ENSMMUP00000061741	ENSMMUP00000035809	ATP binding cassette subfamily A member 1.	Sirtuin 1.	0.450
ABCA1	SREBF2	ENSMMUP00000061741	ENSMMUP00000004473	ATP binding cassette subfamily A member 1.	Sterol regulatory element binding transcription factor 2.	0.795
ABCA1	ZDHHC8	ENSMMUP00000061741	ENSMMUP00000026460	ATP binding cassette subfamily A member 1.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.497
ABCA12	ABCA5	ENSMMUP00000019450	ENSMMUP00000024484	ATP binding cassette subfamily A member 12.	ATP binding cassette subfamily A member 5.	0.491
ABCA12	APOA1	ENSMMUP00000019450	ENSMMUP00000021209	ATP binding cassette subfamily A member 12.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.406
ABCA15	ABCA1	ENSMMUP00000022037	ENSMMUP00000061741	Uncharacterized protein.	ATP binding cassette subfamily A member 1.	0.438
ABCA15	ABCA3	ENSMMUP00000022037	ENSMMUP00000025287	Uncharacterized protein.	ATP binding cassette subfamily A member 3.	0.900
ABCA15	ABCA8	ENSMMUP00000022037	ENSMMUP00000048627	Uncharacterized protein.	ATP binding cassette subfamily A member 8.	0.612
ABCA15	APOA1	ENSMMUP00000022037	ENSMMUP00000021209	Uncharacterized protein.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.402