STRINGSTRING
TNFRSF1B TNFRSF1B ASPA ASPA IL6ST IL6ST KRAS KRAS VEGFC VEGFC DAG1 DAG1 TSPO TSPO SERPINE2 SERPINE2 RNF112 RNF112 HDAC1 HDAC1 PTPRZ1 PTPRZ1 UFL1 UFL1 PPP1CC PPP1CC PRPF19 PRPF19 TTBK1 TTBK1 TP73 TP73 NOTCH1 NOTCH1 OLIG2 OLIG2 NKX6-1 NKX6-1 GJC2 GJC2 E2F1 E2F1 TGFB1 TGFB1 SYNJ1 SYNJ1 GFAP GFAP IL6 IL6 LYN LYN LIF LIF ACY3 ACY3 BIN1 BIN1 MECP2 MECP2 TNF TNF GSX2 GSX2 HDAC2 HDAC2 MDK MDK SHH SHH RHEB RHEB SOX10 SOX10 IL34 IL34 BMP2 BMP2 NKX6-2 NKX6-2 NKX2-2 NKX2-2 NTN1 NTN1 PRKCI PRKCI SOX8 SOX8 TENM4 TENM4 DICER1 DICER1 PLAG1 PLAG1 MTOR MTOR SLC7A5 SLC7A5 SPINT1 SPINT1 LRP2 LRP2 IL1B IL1B PTN PTN EGR2 EGR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFRSF1BTNF receptor superfamily member 1B. (501 aa)
ASPAUncharacterized protein. (329 aa)
IL6STUncharacterized protein. (942 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa)
DAG1Dystroglycan preproprotein. (894 aa)
TSPOTranslocator protein isoform PBR. (169 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
RNF112RING finger protein 112. (631 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
PTPRZ1Uncharacterized protein. (2319 aa)
UFL1E3 UFM1-protein ligase 1. (793 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PRPF19Pre-mRNA processing factor 19. (512 aa)
TTBK1Tau tubulin kinase 1. (1433 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (660 aa)
NOTCH1Notch receptor 1. (2556 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
NKX6-1NK6 homeobox 1. (366 aa)
GJC2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (441 aa)
E2F1E2F transcription factor 1. (437 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SYNJ1Synaptojanin 1. (1614 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (462 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
LYNTyrosine-protein kinase. (577 aa)
LIFLIF interleukin 6 family cytokine. (206 aa)
ACY3Aspartoacylase-2. (319 aa)
BIN1Bridging integrator 1. (668 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
GSX2GS homeobox 2. (304 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
MDKMidkine. (143 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
RHEBUncharacterized protein. (249 aa)
SOX10SRY-box transcription factor 10. (467 aa)
IL34Uncharacterized protein. (364 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
NKX6-2Homeobox protein Nkx-6.2. (277 aa)
NKX2-2Homeobox domain-containing protein. (451 aa)
NTN1Netrin 1. (604 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
SOX8SRY-box transcription factor 8. (617 aa)
TENM4Teneurin transmembrane protein 4. (2929 aa)
DICER1Uncharacterized protein; Belongs to the helicase family. Dicer subfamily. (2011 aa)
PLAG1Pleiomorphic adenoma gene 1 protein. (500 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (507 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (667 aa)
LRP2LDL receptor related protein 2. (4660 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
PTNUncharacterized protein. (172 aa)
EGR2Uncharacterized protein. (489 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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